Donald Metcalf receives American Association for Cancer Research Lifetime Achievement Award
...to levels in bone marrow. Not only was pheresis of peripheral blood a less traumatic and more prolific source of cells for transplantation, but the CSF-elicited stem cells achieved a more rapid recovery of white cell and platelet levels in patients. This dramatic advance has largely replaced bone marrow transpl...Data presented at ISHLT meeting confirm RNA analysis can identify rejection in lung transplant recip
...pelling evidence that profiling gene expression in peripheral blood can detect organ rejection in lung transplant patients. Refining the Identification of Discriminatory Genes for Rejection in Lung Transplantation: The LARGO Study will be presented today by Shaf Keshavjee, M.D., Chair, Division of Thoracic Surg...TXNIP -- regulator of glucose homeostasis and potential diabetes drug target and more
...son LE, Storgaard H, et al. (2007) TXNIP regulates peripheral glucose metabolism in humans. PLoS Med 4(5): e158. IN YOUR ARTICLE, PLEASE LINK TO THIS URL, WHICH WILL PROVIDE ACCESS TO THE PUBLISHED PAPER: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040158 PRES...Scripps research team sheds light on long-sought cold sensation gene
...paper. "It really highlights the importance of the peripheral nervous system and how temperature affects our behavior," he says. The altered mice also showed little response to the application of acetone to their hindpaw, which causes an unpleasant cold sensation, while the acetone caused normal mice to fli...Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
...es light information from the eyes and coordinates peripheral oscillators throughout the body. By examining ef...necessary not only to stabilize oscillators in the peripheral tissues but also to provide a robust response to various genetic mutations. In fact, the network int...Burroughs Wellcome Fund awards $14M to support physician-scientists
...oh, M.D., Ph.D. Washington University Mechanism of peripheral neuropathy from Mitofusin 2 mutations James Elliott Bradner, M.D. Harvard University Design and characterization of highly potent inhibitors of HDAC6 Clark C. Chen, M.D., Ph.D. Harvard Medical School The molecular basis and therapeutic implic...UF researchers awaken vision cells in blind mice
...the eyes rod cells are important for low-light and peripheral vision and exist in much greater amounts, with populations of more 100 million. But treating cones could play a role in diseases that begin with the destruction of rods, such as retinitis pigmentosa, which affects about 1 in 3,000 Americans. "Th...Weill Cornell pharmacologist receives prestigious NIH MERIT Award
... elucidate the role of nitric oxide as it mediates peripheral blood flow, and uncover potential targets for ther...seases such as stroke, coronary artery disease and peripheral vascular disease (2004). ...JCI table of contents: May 24, 2007
...roinflammatory influence on the liver through both peripheral and central mechanisms. The authors suggest that the action of resistin in the hypothalamus may contribute to high blood glucose levels in type 2 diabetics. TITLE: Hypothalamic resistin induces hepatic insulin resistance AUTHOR CONTACT: Luciano ...When the villain becomes your friend: The strange tale of muscle lactate
... Usually, muscles contract because the central and peripheral nervous system signals them to do so. Why do the muscles make lactic acid" Lactic acid is the result of the glycolytic energy production system. It is an energy source to be used in muscle cells of origin, or adjacent fibres (cells), or fibres in th...Gene therapy offers new hope for treatment of peripheral neuropathy
...n, an irritant known to simulate the symptoms of a peripheral neuropathic pain at the site of injection. Followi...gs suggest that HSV-directed expression of GlyR in peripheral neurons and subsequent selective activation by glycine has the potential to be used therapeutically ...Virus widely used in gene therapy research yields important clues to genomic instability
...art, by a single injection of a rAAV vector into a peripheral vein. Recent research has demonstrated that rAAV can only insert itself into host chromosomes at sites that are prone to DNA breaks. The research team, led by Hiroyuki Nakai, M.D., Ph.D., assistant professor of molecular genetics and biochemistry, ...Enzyme delivered in smaller package protects cells from radiation damage
...ematopoietic stem cells, bone marrow stem cells or peripheral blood progenitor stem cells. However, there is increasing concern that such high doses of radiation may have long-term negative effects on healthy tissues and organs, such as the kidney, liver and thyroid gland. Based on previous studies showing t...Cisplatin is more effective than carboplatin for treating nonsmall cell lung cancer
...gnificant baseline renal impairment, hearing loss, peripheral neuropathy, or other serious medical comorbidities, the authors write....News tips from the Journal of Neuroscience
... months of age and increased further with age. The peripheral nerves were unaffected. Blindness was the most obvious consequence of ClC-2 loss, presumably from the retinal damage described previously in these mice. However, neurons appeared normal, and there was no effect on seizure threshold. The pattern of wh...News tips from the Journal of Neuroscience
...the end of the cell at which youre looking. In the peripheral branches of trigeminal sensory neurons, arborizati...y thought of primarily in terms of the disfiguring peripheral nervous system tumors, these patients often have learning disabilities as well. The protein encoded ...Double honors for diabetes researchers
...d international prizes for their research into the peripheral nerve damage suffered by people with diabetes. D...an people with diabetes living in the UK have less peripheral nerve damage and how this relates to altered blood flow in the smallest vessels, said Dr Abbott, who...JCI Table of Contents -- July 2, 2007
...ection was inversely associated with the number of peripheral blood neutrophils in exposed individuals. The ability of whole blood that lacked neutrophils to restrict the growth of M. tuberculosis was impaired 3-fold. The authors went on to show that the neutrophil peptides cathelicidin LL-37 and lipocalin-2 re...Insulin sensitizer also serves as energy-conserving signal to the brain
...haracterizes both conditions. In addition to its peripheral actions on the liver and skeletal muscle, adiponectin has also been reported to have central actions, Kadowaki said. Recently, however, it was reported that adiponectin is undetectable in human cerebrospinal fluid and does not cross the blood-brain b......al levels, movement is based on reflexes driven by peripheral sensors. Control circuits ensure that the joints are not overstretched or that the next step is initiated as soon as the foot touches the ground. Only when the gait needs to be adapted, higher centers of organization step in a process triggered by t...