Tag: "phenotype" at biology news

JCI table of contents November 1, 2004

...ly vascularized, encapsulated, nonmetastatic tumor phenotype AUTHOR CONTACT: Michael Klagsbrun Harvard Medical School, 300 Longwood Ave Boston, MA 02115, USA Phone: 617-919-2157; Fax: 617-730-0233; E-mail: michael.klagsbrun@childrens.harvard.edu View the PDF of this article at: https://www.the-jci.org/press...

Other highlights in the November 3 JNCI

...izes the drug midazolam was associated with CYP3A4 phenotype and is closely related to how quickly the body metabolizes irinotecan. They also found that a specific UGT1A1 mutation was associated with increased amounts of the active inrinotecan metabolite. They conclude that combining CYP3A4 phenotyping with UG...

Grants target better predictors for type 1 diabetes

... don't have the same pathways leading to the final phenotype which is diabetes. There is not going to be one cure for cancer and there is not going to be one cure for diabetes." ...

Muscle loss from space travel, prolonged inactivity linked to two genes

...d Kandarian to assess what changes in the muscle's phenotype were linked to the atrophy process. A slow-to-fast change in phenotype is typical in muscle atrophy. After 10 days of reduced weight-bearing use, all groups of mice...

No getting around RET

...ave failed to reach their normal destination; this phenotype is seen in mice only weakly lacking GFR1 (which is thought by some to regulate NCAM-mediated cell adhesion), but not in mice lacking RET. Again, the Cis-only mice showed no discernible differences from wild type. This comprehensive series of experime...

Researchers discover a stem-cell switch lurking within leukemias

...hese oncogenes are associated with a self-renewing phenotype in humans, in which the disease is continually propagated," said Gilliland. "But we found that only MOZ-TIF2 could confer the property of self-renewal on any type of progenitor cell. BCR-ABL could not turn on those self-renewal programs by itself...

Bound for destruction

...ease in nedd4 activity resulted in the nicked wing phenotype characteristic of Notch loss of function and in reductions of the total amount of the Notch intracellular domain in the cytoplasm of treated cells. Taken together, these results suggested that Nedd4 works as an antagonist of Notch signaling at an ear...

Highlights of January 2005 issue of Biology of Reproduction

...op beyond this stage, it has been thought that the phenotype is dependent on the genotype of the female giving rise to the egg - there are "blocking" and "non-blocking" types of females. In the January 2005 issue of Biology of Reproduction, Hadi, Hammer, Algire, Richards, and Baltz revisit this issue. The rece...

Other highlights in the January 5 JNCI

...e, an effect that is accompanied by a hyperplastic phenotype in these areas that is likely relevant to cancer development. Esophageal and tongue cancers have been associated with dietary zinc deficiency, and these cancers often overexpress COX-2, a characteristic known to contribute to carcinogenesis. Louise Y...

Mutations in transporter protein shed light on neurodegenerative disorders

...d J. Reimer of Stanford University. "In the severe phenotype infants are born with dysmorphic features, enlarged internal organs and die within a few months. With the milder disease the affected individuals have physical and mental developmental delay, but can live to adulthood." In Salla Disease and ISSD,...

Blood test shows promise as monitor for antiangiogenic cancer therapy

...Kerbel: "Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: Implications for cellular surrogate marker analysis of antiangiogenesis" The context and implications of this work are discussed in a Preview by Schneider et al....

Novel asthma study shows multiple genetic input required; single-gene solution shot down

...s, or AHR), the team "used selection for a disease phenotype in a serial backcross" whereby offspring showing c...rental strain, this "suggests the maximally severe phenotype depends on inheritance of more than the two interacting loci we have identified."...

Molecular probes for biology research and drug discovery

...g concentration can result in different degrees of phenotype expression. On top of that, the effect can be initiated and studied at different stages in the development of the organism. Finally, the access to small molecule probes enables anyone to study the effect. How to find molecular probes for chemical gen...

JCI Table of Contents, March 1, 2005

...obal IRS-1 and IRS-2 knockout mice have no obvious phenotype and compound knockouts die in utero. Appearing online on February 10 in advance of publication in the March 1 print edition of the Journal of Clinical Investigation, C. Ronald Kahn and colleagues from Harvard University report a novel approach to in...

Could schizophrenia arise from a single defect?

...y well constitute the molecular basis of a complex phenotype that is generally believed to have a multifactorial background," concluded the scientists....

JCI table of contents, April 1, 2005

...ing cascade that mediates the motile and mitogenic phenotype of thyroid cancer cells AUTHOR CONTACT:Massimo Santoro University Federico II, Naples, Italy Phone: 39-081-7463056; Fax: 39-081-7463037; E-mail: masantor@unina.it View the PDF of this article at: https://www.the-jci.org/press/22758.pd...

A regulatory network analysis of phenotypic plasticity in yeast

... of genetically identical organisms to alter their phenotype in response to an environmental change. For example, genetically identical plants grown in sun versus shade will soon look very different from one another. It turns out that some species are more plastic than others. Until now, we have not been able ...

Researchers trace evolution to relatively simple genetic changes

...l syndrome. Instead, they cause evolution of a new phenotype in natural populations." The research with the wild fish also shows that the same gene is used whenever the low armor trait evolves. "We used sequencing studies to compare the molecular basis of this trait across the northern hemisphere," said Kings...

Growth disorder gene plays a big role in normal size variation

...Mendelian trait like eye color - suggests that the phenotype is controlled by a very small number of genes. In contrast, a complex trait such as body size is influenced by multiple genes as well as environmental factors, giving rise to a continuous spectrum of phenotypes. This causal complexity makes discovery...

Microarrays as phenotype

...ay data. This means the microarray provides a good phenotype that is quantitative. We can prove that gene A comes before gene B and give mathematical support for these findings." "This is a proof of principle that we set out to do assessing the function of unknown genes is feasible," said Shaulsky. "It can be...

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(Date:10/30/2014)... When most animals begin life, cells immediately begin accepting ... organ. However, mammals, including humans, are special. The cells ... choice – to become the protective placenta or to ... critical first step that research from Michigan State University ... current issue of PLOS Genetics , ...
(Date:10/30/2014)... University researchers have developed a suite of technologies that ... humans, which has applications in everything from search and ... "We,ve developed a platform for computer-mediated communication between humans ... for interpreting dogs, behavioral signals and sending them clear ... an assistant professor of computer science at NC State ...
(Date:10/29/2014)... suffers who lose their hair as a consequence of ... will improve the scalp cooling technology that prevents hair ... is being pioneered by global scalp cooling manufacturing company, ... the biology department of the University of Huddersfield. , ... Hussain, who has a background in the pharmacology of ...
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