Cell enzyme may help suppress cancer development
...he enzyme is known as PTPRO (for "protein tyrosine phosphatase receptor-type O"). When the gene responsible for producing PTPRO is silenced, as can happen in lung cancer, for example, the amount of the enzyme drops, allowing the cells to grow when they shouldn't. The research, led by investigators at The Ohio...Natural tumor suppressor in body discovered by UCSD medical researchers
... components of Akt, they specifically looked for a phosphatase linked to the PH domain, a protein module found in a wide variety of chemical signaling proteins in organisms ranging from yeast to humans. Once they found PHLPP, which they discovered was expressed throughout the body, the scientists used biochemi......paired. Dr. Donehower and colleagues show that the phosphatase PPM1D effectively curtails the DNA damage checkpoint response by dephosphorylating the ATM/ATR targets, Chk1 and p53 enabling the cell to resume a homeostatic state. "From my point of view, the most interesting thing about this study is a new insigh...New regulators of apoptosis and chemoresistance identified
...the first large-scale classification of kinase and phosphatase gene families on the basis of their role in apopto...lized RNAi to systematically screen the kinase and phosphatase component of the human genome. They found that 11 percent of kinases control cell survival. As expec...Scripps scientists identify target of an immune suppression molecule called CD22itself
...n enzyme known as a phosphatase. The action of the phosphatase is to remove phosphate groups from other proteins-...ile the business end of the CD22 that recruits the phosphatase and keeps the B cell in check is on the inside of the cell membrane, the trigger that shuts CD22 off...Discovery of new dopamine action may yield alternative psychiatric drugs
...ontaining beta-arrestin 2, Akt and a third protein phosphatase 2A that inactivates Akt. Mice lacking beta-arrestin become less responsive to certain drugs and exhibit abnormalities in behaviors, such as locomotion, associated with dopamine. In addition to the behavioral deficits, the animals also lack normal reg......rged from the screen as the first protein tyrosine phosphatase to inhibit JAK/STAT signaling. Since the JAK/STAT pathway is conserved between insects and mammals, the authors speculate that many of the new genes that they have identified will turn out to be important to understanding the role of this pathway in ...JCI table of contents November, 2005
... useful in treating SLE patients. TITLE: Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus AUTHOR CONTACT: George Tsokos Walter Reed Army Institute, Silver Spring, MD USA Phone: 301 319 9911; Fax: 301 319 9133; E-mail: gtsokos@usuhs.mil View th...The tumor suppressor protein phosphatase 2A offsets the BCR/ABL oncogenic kinase
... uncovered an unexpected functional link between a phosphatase known to act as a tumor suppressor and BCR/ABL, a ...pendent on an intricate balance between kinase and phosphatase activities. In the case of CML, constitutive activity of the BCR/ABL oncoprotein contributes to dise...'Computer-chemistry' yields new insight into a puzzle of cell division
...red the probable orientation required for a Cdc25B phosphatase enzyme to "dock" with and activate a cyclin-depend... sites" -- where chemical reactions occur --on the phosphatase and the kinase to link precisely, Rudolph said. The two molecules' component parts, or "residues," m......ASS Medical School) identify the long sought-after phosphatase for Smad in the BMP signal transduction pathway. ...s. Dr. Xu's new paper now reveals the elusive Smad phosphatase in the BMP pathway. The researchers used an RNAi approach to identify pyruvate dehydrogenase phospha...Penn clinical chemist wins prestigious Ullman Award
...tane substrate, now widely used to detect alkaline phosphatase labels and other hydrolytic enzymes. He has also played an important role in adapting chemiluminescent and bioluminescent assays to point-of-care testing. His second defining work, in collaboration with Dr. Peter Wilding, PhD, is with miniaturizatio...Rutgers researchers find fat gene
...scovery that lipin is an enzyme (phosphatidic acid phosphatase or PAP), a protein catalyst that is required for the formation of fats triglycerides, specifically. The breakthrough for Carman's group grew out of work with ordinary baker's yeast; a simple single cell organism. "We isolated the PAP enzyme from ye...Stowers scientists clarify role of tumor suppressor gene
...ghlighting several previously unknown functions of phosphatase and tensin homolog (PTEN), an important tumor suppressor gene. The findings, published on the Nature Web site on April 23, identified an intrinsic pathway involving PTEN that helps control the transitions that stem cells make between the quiescent ...NIH awards $13.3 million to Carnegie Mellon, University of Pittsburgh
...created fluorescent probes to visualize kinase and phosphatase reactions. But there are many hundreds of these reactions within cells, and they are critical to driving pathways involved in disorders like cancer, diabetes, stroke and infection." Integrated molecular biosensors could be sprayed onto implantable mi...JCI table of contents: June 22, 2006
...POMC neurons by inactivating the gene for the PIP3 phosphatase Pten in these cells in mice. This resulted in an excessive ingestion of food beyond what was needed by these animals and diet-induced obesity. Leptin administration failed to significantly inhibit food intake. Interestingly, POMC neurons showed a red...JCI table of contents: August 17, 2006
... shown that Tregs from mice with T cells that lack phosphatase and tensin homolog (PTEN) proliferate in response to IL-2. Importantly, PTEN-deficient Tregs retained their suppressive function in vitro and in vivo, indicating that loss of PTEN by Tregs only affects their proliferative capabilities in response to ...... shown that Tregs from mice with T cells that lack phosphatase and tensin homolog (PTEN) proliferate in response to IL-2. Importantly, PTEN-deficient Tregs retained their suppressive function in vitro and in vivo, indicating that loss of PTEN by Tregs only affects their proliferative capabilities in response to ...News tips from the Journal of Neuroscience
...junction (NMJ) and pulled out a subunit of protein phosphatase 2A (PP2A), a serine threonine phosphatase required for many cellular processes. The authors generated >2500 transposable P-element inserti......authors show that calcineurin, a calcium-activated phosphatase implicated in many forms of synaptic plasticity, is essential to this behavior. The authors engineered a mutant lacking calcineurin expression in interneurons but not sensory neurons. Whereas the mutant sensed temperatures normally, it did not stay a...