Researchers identify cell pathway in colon cancer
...rget regulated by PTPRT {Receptor Protein tyrosine phosphatase T}, which was previously identified to be mutated ...h cancer patients. "The role of protein tyrosine phosphatase in cancer is still an under-explored area. Our study shows that receptor protein tyrosine phosphatas...News tips from the Journal of Neuroscience
...h its phosphorylation, a state reversed by protein phosphatase 2A (PP2A), which itself is affected by methylation. Previous studies have also reported downregulation of neuronal PP2A methyltransferase (PPMT) and reduced PP2A methylation in brain tissue from Alzheimers patients. In neuroblastoma cells, the author...Making memories that last a lifetime
...ory suppressor gene they studied is called protein phosphatase 1, and the memory-promoting gene is called reelin. "To our knowledge, this study is the first to present evidence that DNA methylation, once thought to be a static process after cellular differentiation, is not only dynamically regulated in the adu...MU researchers make discovery in molecular mechanics of phototropism
...dly dephosphorylated by a yet unidentified protein phosphatase in response to phot1 photoactivation by blue light. Liscum and Pedmale now plan to study which amino acids on NPH3 are reversibly phosporylated and how NPH3 is involved in regulating other processes within plants. ......ations in the protein SHP2 (Scr homology region 2, phosphatase 2) occur in approximately half of all NS patients with cardiac abnormalities. Robbins et al. used transgenic mice bred to express a mutated form of SHP2 in heart muscle cells during gestation or following birth. Embryonic hearts containing the mutate...