Tag: "phosphate" at biology news
Convening kidney health in Copenhagen
...ween two key regulators of calcium, magnesium, and phosphate
metabolism: the bone and the kidney. Opening with ...a's (USA) lecture on New challenges in calcium and phosphate
metabolism, the three and half days of exciting scientific discourse and exchange will incorporate a...
New cancer drug hope
...s; they modify other proteins by chemically adding phosphate
groups to them. In cancer, both these protein kinases are 'overexpressed'. The University of Manchester team has been working on the Aurora B inhibitor in collaboration with pharmaceutical company AstraZeneca. The group published an earlier paper i...
The power behind insect flight: Researchers reveal key kinetic component
...st muscle fibers, Swank's team has discovered that phosphate
release is the slowest step of the reaction. This...e, ADP release has been sped up to the point where phosphate
release is the primary rate-limiting step that determines how fast a muscle can contract," Swank sai...
Funnel in the eye: Signal focusing increases photosensitivity
...at 'apparently, under the influence of dopamine, a phosphate
group is bound to Cx36 and inhibits the channel.' It is the first time that direct proof has been available that this mechanism exists. The importance of signal focusing is demonstrated by mice which cannot produce Cx36. Their amacrine II cells can...
JCI table of contents: November 9, 2006
...as not present in sufficient numbers. In addition, phosphate
levels in the blood were abnormally high. This study, therefore defines a role for chondrocytes in bone development. TITLE: Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts AUTHOR CONTAC...
...material is DNA. Its backbone is made of sugar and phosphate
building blocks. Like a strand of pearls, the four "letters" of the genetic code are arranged along this backbone. Two complementary strands of DNA form a double helix because the purine bases adenine (A) and guanine (G) form specific pairs with the ...
Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity
...that is critically dependent upon the base, sugar, phosphate
and location when the trigger loop swings into position, Kornberg said. If it is misaligned even slightly, that set of contacts cannot occur. As a consequence of that alignment, to angstrom (a unit of length equal to one hundred millionth of a centi...
Scientists uncover speedometer for crystal growth controlled by biomolecule properties
...ogic history and its close relation to the calcium phosphate
found in the bones and teeth of all mammals. One ongoing question is how organisms form these mineralized structures, or biominerals, at a controlled rate, sometimes very rapidly until attaining the prescribed size. For reasons not well understood...
Cocaine high caused by interference in neuronal receiving stations
...ves addition to NR2B of a molecular group called a phosphate
by an enzyme called a kinase, and the cocaine-induced D2R attachment blocked this event. Wang and his colleagues found that this interaction between D2R and NR2B occurred specifically in the striatum of the brainthe region known to be responsible f...
Detailed 3-D image catches a key regulator of neural stem cell differentiation in action
...called kinases turn the "light" on by adding small phosphate
chemical groups - giving RNA polymerase the go-ahead to transcribe genes - while removal of those phosphates by phosphatases like Scp1 turns out the light, effectively stopping RNA polymerase in its tracks. Noel and postdoctoral fellow Yan Zhang, ...
Boost for new cancer therapies
... kinase enzymes which use a particular chemical a phosphate
to catalyse the reactions that lead to cell divis...as identified a new target protein that uses these phosphate
groups to switch on genes and alter the properties of cells. "When the actions of enzymes like Pol...
NSF funds biofertilizer research at Rutgers-Camden
...rs" that reduce the farming industry's reliance on phosphate
and nitrogen fertilizers that pollute water suppli...used by the plants, leading to excess nitrogen and phosphate
causing ecological problems by leaching into the groundwater and overfertilizing aquatic ecosystems....
Gene that makes people 'early to bed and early to rise' demystified
...cine, prevented a regulatory enzyme from tacking a phosphate
onto the encoded protein. Now, the researchers report additional evidence that the lost "phosphorylation" prevents a cascade of chemical modifications that are normally primed by the initial event. Moreover, they show that the human gene inserted ...
Disorderly protein brings order to cell division
...ed CDK2; yet we also knew that CDK2 tags T187 with phosphate
even while it still carries the p27 yoke on its sh...se, which is why it can tag the hand of p27 with a phosphate
group. The team showed that a specific type of kinase tags the elbow of p27 at a spot called ami...
New mechanism for nutrient uptake discovered
...n regulatory event called phosphorylation, where a phosphate
molecule is introduced to another molecule, changing the latter, and preparing it for a chemical reaction. They have found a site for phosphorylation and are looking at this possibility further. A leading expert in transporters, Professor Dale San...
Researchers find the mechanism by which cells resist chemotherapy
..., the ATR kinase, which phosphorylates (introduces phosphate
groups into) histone H2AX, a protein present in the chromatin that surrounds the damaged DNA. The phosphorylated histone H2AX indicates the location of the genetic damage to the Fanconi proteins and places them in exactly the right place to repair th...
Darwin's famous finches and Venter's marine microbes
... of proteins and small molecules by attaching tiny phosphate
groups to them. By contrast, much less has been known about their bacterial counterparts. Again and again, the researchers combed the GOS data for bacterial kinases, each time rebuilding their domain profiles by including the new members found in t...
DNA layer reduces risk of reserve parts being rejected
...nse immune response occurs. Further DNA is rich in phosphate
groups that can speed up the attachment to bone ti...s also found to speed up the deposition of calcium phosphate
and could, for example, be adapted to promote bone and blood vessel formation. The good research res...
Researchers figure out what makes a simple biological clock tick
...the regular increase and decrease in the number of phosphate
groups attached to the KaiC molecules. The attachment and detachment of phosphate
groups a process called phosphorylation and dephosphorylation is a common method of protein regula...
Mutation improves memory, may lead to memory-enhancing pill
...IF2a is chemically modified with the addition of a phosphate
to one of its amino acids, it switches on the protein synthesis of another factor that halts production of genes required for the long-term storage of memories. Sonenberg and his colleagues previously discovered that mice lacking the enzyme that perf...
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