Creation of gene targeting earns Smithies March of Dimes honor
...mes. "Before gene targeting, researchers could not pinpoint how a specific gene worked, which was very frustrating," said Dr. Jennifer L. Howse, president of the March of Dimes. "Dr. Capecchi and Dr. Smithies, working independently, made a technological breakthrough that completely revolutionized biomedical r...Researchers develop promising new gene network analysis method
... reliable way to map complex gene interactions and pinpoint genes that may be potential cancer treatment targets, according to new Brown University research. The research is important because it describes a promising new tool for tracing human gene connections, a task critical for understanding and treating c...UCLA scientists pinpoint region of autism gene on chromosome 17
...ed inconclusive. No researchers have been able to pinpoint a predisposing gene and then duplicate their efforts a key piece of proof required for scientific validity. FINDINGS For the first time, a team of UCLA geneticists have isolated the likely region of an autism gene on chromosome 17 and then success...New insights into how Huntington's disease attacks the brain
...ract with the target cells to spark disease." To pinpoint the disorder's cellular origin, UCLA researchers d...isease," said Yang. Yang's team is now trying to pinpoint which of the neighboring cells generate Huntington's disease. "Our next step will be determining how...Ophthalmologists implant five patients with artificial silicon retina microchip
... eye and replaces it with saline. They then make a pinpoint opening in the retina through which they inject fluid to lift up a portion of the retina from the back of the eye, creating a small pocket in the "subretinal space" just wide enough to accommodate the ASR. The surgeons then enlarge the pocket opening...Satellite images give a better picture of sediment transport
...1). The model can determine the erosion fluxes and pinpoint the areas of particle deposition. Validation and refinement of the models are achieved by means of in situ measurement of turbidity, and of sediments, in order to determine in particular the degree of heterogeneity of the sea floor characteristics: w...Two-part blood pressure control suggests new approach to hypertension therapy
... blood vessels and brain, has made it difficult to pinpoint the proteins' roles in individual tissues, Coffman said. To clarify the function of AT1 receptors, the researchers transplanted the kidneys of normal mice into mice in which the AT1 receptor had been rendered nonfunctional, and vice versa. Mice with ...BRCA1 causes ovarian cancer through indirect, biochemical route
... to diagnose a predisposition to ovarian cancer or pinpoint just who is at risk, simply by measuring the chemical's levels. "The consequence of this finding," Dubeau says, "is that ovarian cancer is the result of some biochemical problem that may be correctable or preventable. That's what makes this finding s...Same mutation aided evolution in many fish species, Stanford study finds
...However, in the fin study the group wasn't able to pinpoint the exact genetic alteration. The group continues to wade out into nature, collecting additional stickleback species from around the world that can reveal whether particular genes are always reused when the animals adapt to new conditions, or if evol...Two UCSF scientists receive top funding honor from medical institute
...nique that allows scientists for the first time to pinpoint where small molecules called phosphates attach to proteins in cells, allowing the cells to send signals and gives organisms a way to adapt to rapidly changing conditions. Diabetes, hypertension and many cancers arise when these simple, nearly ubiquit...Chemical engineer Kao explores antibiotic synthesis with DNA chips
...e timing of erythromycin production, but could not pinpoint the specific mutation. A similar study by Kao's group identified two genes responsible for overproduction of the antibiotic tylosin. Instead of increasing the length of time that a bacterium produces the antibiotic--the case with erythromycin--these ...MGH study identifies potential Alzheimer's risk gene
...t MIND, lead author of the study. "We now have to pinpoint the biological defects that accompany this finding, which also needs to be independently replicated in other Alzheimer's sample groups." Bertram is an assistant professor of Neurology at Harvard Medical School (HMS). Mutations that raise the risk o...JCI table of contents March 1, 2005
...g network used by the fungus to wreak havoc. They pinpoint a protein called Vad1 (virulence-associated DEAD box RNA helicase-encoding protein) as a regulator of virulence genes. The paper provides new and important information on how the fungus Cryptococcus neoformans causes disease. In an accompanying comm...Tailing the cause of a rare heart disease
... culprit gene. In the latest study, they sought to pinpoint the gene and identify the mutation that was responsible. A search of the human genome database identified candidate genes in the region, and subsequent tissue analysis revealed that one gene, called EYA4, was expressed in both the heart and the cochl...California researchers help map human genetic variation across populations
...n based on whole-genome data, and speed efforts to pinpoint DNA variations that are associated with disease or with how patients respond differently to drugs. "This project sets a new milestone in the search for genetic elements linked to complex genetic diseases such as Alzheimer's, cancer and multiple scler...Scientists discover how climate change causes the simultaneous boom or bust of multiple populations
...in breeding success. The research is the first to pinpoint the specific role of climate in causing such incidents of spatial synchrony in animals. "Our study shows that climate events can synchronize the growth trajectory of populations over large areas, having effects on ecological processes that could be...Map of human genetic variation across populations may promise improved disease treatments
...hree human populations could help speed efforts to pinpoint disease-related DNA variations, and ultimately may promise more effective, individualized treatments. The research, scheduled to appear 18 February in Science, "will provide an invaluable resource for genetic research to improve human health," said D...JCI table of contents March 1, 2005
...study its physiological function. The researchers pinpoint two ways that lubricin protects joints. First, lubricin preserves the cartilage surface by preventing protein deposition and protecting the cells that make cartilage. Second, lubricin controls the growth of cells in the joints. These findings are ...Tree-ring data reveals multiyear droughts unlike any in recent memory
...ing something the model used in the project cannot pinpoint as precisely as it can the years the droughts persisted. The second worst corresponds to the 1930s dry period that, together with poor farming practices, caused the Dust Bowl. The Columbia River Basin experienced multiple years of low flows, punctuat......eleterious, the HapMap also may be used to help to pinpoint genetic variations that contribute to good health, such as those protecting against infectious diseases or promoting longevity. "We are excited by the opportunity to apply our technology to all publicly available SNPs. This effort is so important th...