'Shuttling' protein possibly key to resilience of cancer cells
...ource. The fluorescence enabled the researchers to pinpoint the location of c-Jun-ATF2 heterodimers and discover the shuttling movements of ATF2. The ATF2 protein also has been found in the cytoplasm of diseased brain cells in Alzheimer's disease and muscle cells in the heart, suggesting the same shuttling me...A new tree of life allows a closer look at the origin of species
...200 telephone books) has made it very difficult to pinpoint the information needed for a high-resolution map of evolution. But our study shows how this challenge can be tackled by combining different computational methods in an automated process." Bork's lab specialises in the computational analysis of genome...New route to stroke therapy could protect vulnerable neurons
...unit has been disrupted. The editing consists of a pinpoint alteration in the messenger RNA when it is first produced, to prepare it to become a functioning blueprint in the protein-production machinery. Significantly, the researchers found that, by using a genetic technique to switch this editing machinery b...A better tool to study role of iron in Alzheimer's, Parkinson's
Engineers have found a way to pinpoint and identify the tiny iron oxide particles associated with Alzheimer's and other neurodegenerative diseases in the brain. The technique is likely to accelerate research on the cause of the diseases and could lead to the first diagnostic procedure for...High-tech tags on marine animals yield valuable data for biologists and oceanographers
...loped at SMRU have greatly improved the ability to pinpoint an animal's geographic location, and researchers are adding new capabilities to the tags, such as measuring the chlorophyll content of the water (an indicator of algal blooms or "primary productivity"). "We can now use animals to show us things like...Less is more, gene study shows
... humans lost that gene so long ago, it was hard to pinpoint the evolutionary forces behind the loss. So the researchers focused their attention on another human-specific pseudogene, CASPASE12. Work by other researchers had shown that the gene has completely lost its function in non-Africans, but a small per...Study finds 60 new genes controlled by DNA snippet
... regulatory elements as we can to help geneticists pinpoint a growing number of disease-causing mutations." Study Details In Miano's study, the regulatory sequence under examination was the CArG box. The nucleotide building blocks of DNA chains may contain any one of four nucleobases: adenine (A), thymine (...Marsupial genome reveals insights into mammalian evolution
...ecause their genes can be so similar it is hard to pinpoint regions that remain unchanged because they serve a...cental mammal genomes, yet are different enough to pinpoint regions that have important functions and therefore have been conserved for long periods of time. Th...Academy awards medal to noted expert in disappearing amphibians
...in every part of the world but have been unable to pinpoint one single culprit. Habitat loss, pollution, over-harvesting and a recently discovered fungal disease can explain the disappearance of only about half the decline, according to the National Wildlife Federation. "We selected Dr. Wake for the award in ...Mining for gems in the fungal genome
...ecies continued. Although scientists were able to pinpoint the locations of genes believed to be involved in the production of secondary metabolites by pouring over the sequence data, the actual activity of the genes and their gene products still needed to be confirmed. The method developed by Keller and h...Oh, rats! Designer animals reveal possible heart disease genes
... Health Organization. Scientists have struggled to pinpoint the precise genes behind this complex disease. Now... with and without high blood pressure, in order to pinpoint candidate genes behind heart disease. In total, the scientists built 2,200 microarray gene expressio...Stanford/Packard scientist's data-mining technique strikes genetic gold
...on data from so-called microarray experiments - to pinpoint genes likely to be involved in leukemia, aging, injury and muscle development. "This is just the tip of the iceberg," said bioinformatics specialist Atul Butte, MD, PhD, who is also a pediatrician at Lucile Packard Children's Hospital at Stanford. "N...Scientists narrow the time limits for the human and chimpanzee split
...n-chimp divergence. "While this research does not pinpoint the precise time of the split, it tells us that proportional differences on branches in family trees should be considered when proposing new times. For example, we now know that a 10-to-12-million-year human-chimp split would infer a divergence of O...Mercury in atmosphere could be washed out more easily than earlier believed
...tzendruber said. The researchers are only able to pinpoint a source of mercury if the air mass arrives at the observation station within a few days after the mercury is emitted. Measurements of other chemicals in the air help provide evidence of the origin, but after a few days in the free troposphere air ma...Slight increased risk of major birth defects associated with IVF
...n 'blame' for the problem but rather are hoping to pinpoint areas of the IVF treatment that could be changed to improve the safety for children." While the team had the advantage of using one of the most comprehensive and respected birth defect registries in the nation, it would take a much larger study invo...UF's McKnight projects combat memory maladies
...elated tasks. While Loring and colleagues hope to pinpoint the regions of the brain that contribute to successful memory formation and develop a technique to test the effectiveness of drugs used to fight memory loss, Moroz is attempting to determine why some brain cells age more quickly than others. Answers ...UF, Columbia scientists closer to new cancer detection method
...ithin extremely complex fluid or tissue samples to pinpoint biomarkers - proteins that signal that something is amiss. "Even when the cancer biomarkers are in extremely low concentration we have been able to detect them," said Weihong Tan, Ph.D., a UF Research Foundation professor of chemistry in the College ...Two genetic traits giving Africans malaria protection lose effectiveness when they occur together
...ature Genetics--shows how challenging it can be to pinpoint protective genes and, moreover, predict how they might be influenced by other traits. (Thursday, 11:50 a.m., Iroko Hall, Parallel Session 23, Presentation 148) "This is an important finding in part because a huge effort is being poured into malaria g...AACR-NCI-EORTC international conference
...n of drugs capable of destroying cancer cells with pinpoint accuracy, without damaging adjacent normal cells. Each year, the American Association for Cancer Research (AACR), jointly with the National Cancer Institute (NCI) and the European Organisation for Research and Treatment of Cancer (EORTC), brings toge......ogical, behavioral and physiological approaches to pinpoint the multifunctional glycoprotein CD36 (also termed fatty acid transporter, FAT) as the sensor for fat. They show that lingual stimulation of CD36 by fatty acids influences behavioral and digestive physiology. CD36 gene inactivation fully abolishes ...