Common gene version optimizes thinking -- but with a possible downside
...ns by Greengard's team that ultimately linked this pivotal protein to depression and substance abuse as well as to schizophrenia," added NIMH Director Thomas Insel, M.D. To understand DARPP-32's role in the human brain, the NIMH researchers used genetic, structural and functional magnetic resonance imagin...New player in commitment to life as a fat cell
Researchers have discovered a pivotal new player in early events that commit fat cell precursors to becoming full-blown fat, according to a report in the February issue of the journal Cell Metabolism, published by Cell Press. Drugs that block some activities of the enzyme, known as xanth...UCR involved in discovery of diabetes fighting molecule
...t Professor of Bioengineering, Jiayu Liao played a pivotal role in the discovery of a small molecule that has been shown to control diabetes in mice and may pave the way to the development of easier treatment for adult-onset diabetes. This discovery was a collaboration between Liao at UC Riverside's Bourns...Green Chemical Reactor Engineering -- XI
...y technologies. Chemical reactor engineers will be pivotal in the discovery and implementation of new environmentally acceptable products and processes, safety strategies and policies, computer modeling for process control and process simulation. It is anticipated that key enablers to meeting these new chall...Researchers barcode DNA of Venice museum's vast fungi collection
..." said Garbelotto. "This provides governments with pivotal information needed to avoid repeated introductions of pathogens." Garbelotto is working with Italian mycologist Giovanni Robich and Luca Mizzan, curator of Marine Biology at the Venice Museum of Natural History, to sort through the samples in the m...After 2 years, study shows Revlimid patients live longer and remain transfusion free
...arch Institute, presented the final results from a pivotal Phase II trial evaluating Revlimid in patients with an incurable blood cancer known as myelodysplastic syndromes (MDS) at this years American Society of Hematology (ASH) meeting. This breakthrough data showed that in MDS patients with chromosome 5q ...Eculizumab is well-tolerated and shows significant improvement in PNH patients (Ph III)
... marketing applications also contain data from the pivotal Phase III TRIUMPH trial, which met all pre-specified primary and secondary endpoints with statistical significance. Details regarding the TRIUMPH study results are included in an article published in the September 21, 2006 issue of the New England J...NHGRI funds large-scale sequencing centers
...disease. The Genome Sequencing Centers will play a pivotal role in our systematic effort to assess the range of genomic changes associated with malignancy," said Mark S. Guyer, Ph.D., director of NHGRI's Division of Extramural Research. "This genomic information will provide the research community with a po...Europe's leading life science researchers are to convene for the first annual EuroBioForum
...ping and archiving mouse models, which will play a pivotal role in the future diagnosis and treatment of human diseases. The nascent field of nanotechnology, with its near-limitless potential in a wide range of areas, has come to be known in the scientific community as the next 'blue-sky' field. The main aim...Researchers find that bumblebees' flower choice matters
...te professor of Biological Sciences. The bees are pivotal players in determining which plant populations survive through successful reproduction. If scientists could better understand nature's decision-making process, then they could use the information to increase crop yields and to boost conservation of n...Data show treatment with Remicade reduced hospitalizations for ulcerative colitis patients by half
...e results from two randomized, placebo-controlled, pivotal Phase 3 clinical trials, ACT 1 and ACT 2. Fifty-four week results from the ACT 1 trial further demonstrated the long-term safety and efficacy of REMICADE in patients with moderately to severely active UC and found that REMICADE therapy not only induc...West Australian fossil find rewrites land mammal evolution
...day in the journal Nature. "Gogonasus is the new pivotal fossil for understanding the earliest phase in the transition from sea-going fish to land-dwelling tetrapods - from dinosaurs, to kangaroos, and ultimately, us humans,'' Mr Fitzgerald said. "The fossils of Gogonasus raise the possibility that tetra...Structure determined for key molecular complex involved in long-term gene storage
... Biology. "The two-molecule complex we studied is pivotal for protecting certain genes from expression, genes that could cause problems if they were activated," says Ronen Marmorstein, Ph.D., a professor in the Gene Expression and Regulation Program at Wistar and one of the two senior authors on the study. ...Untangling a pathology of Alzheimer's
...and a cell-free system suggest that PSA may play a pivotal role in protection from tau-induced neurodegeneration, most likely by direct cleavage of tau," they wrote. The researchers cited studies from other laboratories showing that turning off the mutant, pathological form of tau in mice after the mice sho...First human study confirms that immune cells can be a primary cause of bone loss in gum disease
...igand, (RANKL)-mediated osteoclastogeneis, and the pivotal role it plays in inflammatory bone resorption. The aim of this study, which will be published in the September issue of the American Journal of Pathology, was to identify the cellular source of RANKL in the bone resorptive lesions of periodontal dis...FSU biologists uncover mechanisms that shape cells for better or worse
... of the oocyte," Deng said. "That knowledge adds a pivotal link to our understanding of precisely how cell-to-cell communication occurs in this model system." In recognition of groundbreaking work to-date by the FSU scientists -- and to further the understanding of the mechanisms involved in cell-cell comm...With few factors, adult cells take on character of embryonic stem cells
...ntenance of embryonic stem cell identity also play pivotal roles in the induction of pluripotency" in other body cells, he explained. The researchers selected 24 genes--all previously found to play a role in early embryos and embryonic stem cell identity--as candidate factors that might give body cells th...Ocean microbe census discovers diverse world of rare bacteria
... "From an evolutionary perspective, they are of pivotal importance. They were the only kinds of life on Earth for approximately 80% of the planet's history. All multi-cellular life depends upon microbial processes. The microbes can live without us but we are totally dependent upon them for our continued ...Erectile dysfunction: Incidence rate linked to type and severity of coronary artery disease
...han cardiologists first see these men, they have a pivotal role to play. Cardiologists need to be actively involved not only in detecting and treating ED in their own patients, but in working with urological colleagues to develop a multi-disciplinary management plan. ED is a distressing problem, which should...Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity
...ointing to this region of the p53 protein as being pivotal to its anti-cancer activity. Clearly, a detailed view of the p53 protein in direct contact with DNA could provide important insights into preventing and treating an array of human cancers. To date, however, despite having learned a good deal about ...