HIV infection requires B cells with special protein, University of Pittsburgh researchers report
...lls themselves do not become infected, they play a pivotal role as an accomplice in HIV's takeover of T cells. "We have new insight into how the virus does its damage. The pathway is surprisingly simple, yet it has important implications for future studies and drug development efforts that focus on reservo...Cure found for Huntington disease in mice offers hope for treatment in humans
...T and lead author in the study. This work is also pivotal for the individuals and families affected by Huntington disease. "Patients of this disease should know that this is a research milestone for all and that this work brings the field closer to finding effective treatment for a devastating disorder", sa...Fly's courtship sheds light on the formation of innate behaviors
...erience. One gene, fruitless, has been shown to be pivotal to the emergence of these stereotypical behaviours. Fruitless is known to generate a variety of similar but functionally different proteins, some of which are exclusively expressed in male flies. Using a mutant that specifically disrupts one form of ...Queensland scientists identify molecule that links both sides of the brain
...a variety of molecular guidance systems which play pivotal roles in the guidance of nerve fibres and newly born neurons throughout the developing central nervous system....Einstein's Susan Band Horwitz, PhD wins Bristol-Myers Squibb Cancer Research Award
...vel that cause resistance to these compounds. Her pivotal research in the 1980's eventually led to the development of paclitaxel (Taxol), one of the most important anti-cancer agents ever developed. Dr. Horwitz was selected to receive the Distinguished Achievement Award by an independent panel of her peers,...Discoveries should aid research into cause of ALS
... long overlooked part of the SOD1 protein, plays a pivotal role. The ALS mutations appear to predispose SOD1 to form incorrect disulfide bonds that lead to aggregation of the protein and perhaps initiation of the disease. If these ideas are borne out, our next step is to look for therapeutic approaches that ...Celgene founder Sol J. Barer to receive 2006 Winthrop-Sears Award
...off as a stand-alone company. Among numerous other pivotal roles, he established and implemented Celgene's overall business strategy and led the development of its technology platforms (oncology and immunology). Earlier in his career, in addition to holding senior positions at Celanese, Barer was also with C...Even at small scales, the big decisions are made at the water cooler
...t an important task, it is sometimes said that the pivotal discussions do not happen in large, well-attended meetings, but in one-on-one conversations around the water cooler. It turns out that among individual neurons in our brains, the same may hold true. Likening the process to the sort of casual conver...16-Year follow-up study reinforces Betaseron long-term efficacy, safety and tolerability in MS
...than 80 percent of the time since the start of the pivotal trial (approx. 12 years or longer), while short-te...nt of patients who first enrolled in the Betaseron pivotal trial between 1988 and 1990. Of the original 372 patients involved in the pivotal trial, 328 (88.2 ...CU, Harvard researchers team up to break down causes of Alzheimer's
... 23 issue of Nature, finds the enzyme also plays a pivotal role in guarding against a second type of lesion, the buildup of plaque, or flat deposits on the surface of brain cells. Alzheimer's is caused by the two types of lesions, or alterations in brain tissue, occurring simultaneously. Researchers at Corne...Sherry Lansing and Janet Woodcock receive AACR public service awards
...th the FDA since 1986, is being recognized for her pivotal leadership role in streamlining and reorganizing the agency's oversight of cancer medicines through the creation of the new Office of Oncology Drug Products. She introduced the concept of pharmaceutical risk management in 2000 and her leadership of t...Emory scientists discover unique binding method for essential cellular protein ubiquitin
...he Emory scientists focused on IsoT because of its pivotal role in degrading, recovering and reusing ubiquitin from ubiquitin chains. "Although scientists knew that IsoT had an essential role in the recycling of ubiquitin, the structure of IsoT and how it recognized and bound to ubiquitin was not understood,...New research shows Pin1 enzyme is key in preventing onset of Alzheimer's disease
...ains of Alzheimer's disease patients, also plays a pivotal role in guarding against the development of amyloid peptide plaques, the second brain lesion that characterizes Alzheimer's. These new findings, shown in an animal study, provide further evidence that Pin1 (prolyl isomerase) is essential to protect i...UC Davis study with mice links thimerosal with immune system dysfunction
... senior author of the study. "Dendritic cells play pivotal roles in overcoming viral and bacterial invaders by coordinating the immune system's overall combat response." One dendritic cell can activate as many as 300 T-cells white blood cells that help find and kill external agents that attack the immune sy...Special issue of the Journal of Industrial Ecology focuses on eco-efficiency
...analysis, helping us to understand much better the pivotal role the economy-environment tradeoff plays in shaping the quality of our environment." Using these techniques, journal contributors examined eco-efficiency in small businesses in South Korea; in the UK steel and aluminum industries; of a region in...Gene influences antidepressant response
...ptor for the chemical messenger serotonin, plays a pivotal role in the mechanism of antidepressant action. The study, authored by National Institute of Mental Health (NIMH) researchers Francis J. McMahon, M.D., Silvia Buervenich, Ph.D., and Husseini Manji, M.D., along with collaborators at the National Human...Broad Foundation donates $25 million to create new stem cell institute at USC
...in California. The new Broad Institute will be the pivotal hub for integrative biomedical research on USC's Health Sciences Campus, bringing together researchers, biologists and equipment in one place as they investigate the causes and treatments of a wide spectrum of diseases. "This will hopefully be the an...Biovest International submits amendment request to FDA for use of molecular remission data
...formal amendment request to the FDA seeking to use pivotal Phase 3 data on molecular remissions, combined with physical examination and CT scan evidence of gross tumor remission, to gain conditional approval of BiovaxID for treating follicular non-Hodgkin's lymphoma. Biovest has proposed that the data be an...Genomics-based vaccine could prevent deadly cattle disease
...demy of Sciences , shows how genomics can generate pivotal new vaccines. In the study, scientists from five institutions, including The Institute for Genomic Research (TIGR), identify five vaccine targets, or candidate proteins that could form the basis for an East Coast fever subunit vaccine. Based on combi......d colleagues suspected that BDNF plays a similarly pivotal role in social learning. To find out, they first subjected mice to a different dominant mouse daily for 10 days. Even 4 weeks later, the "socially defeated" animals vigorously avoided former aggressors or unfamiliar mice. BDNF and an indicator of g...