Molecular force field helps cancer cells defend against attack
...erest for understanding the functions of these two pivotal molecules in cell behavior, as well as sharpening the focus of FAK-based drug discovery efforts to control cancer."...Researchers map of genetic variations implicated in disease
...diabetes and rheumatoid arthritis. The MHC is also pivotal in response to infection, including malaria and AIDS. Genes in the MHC can differ dramatically between people, and the differences among us affect medical events as diverse as tissue transplant rejection, arthritis, asthma and disease resistance. A...BiovaxID yields 89 percent survival in patients with aggressive non-Hodgkins
... B-cells." Biovest is now enrolling patients in a pivotal Phase 3 trial to test BiovaxID against follicular non-Hodgkin's lymphoma (NHL). Follicular NHL is an indolent (slow-growing) form of lymphoma not considered curable with existing therapies. The impressive findings from the Phase 2 clinical trial usin...Darkness unveils vital metabolic fuel switch between sugar and fat
...o mammalian hibernation, researchers note that the pivotal metabolic signal that emerged from the dark also p...or brain function, the paper notes. "5'-AMP is a pivotal metabolic signal whose circulatory level determines the balance of the peripheral organ energy suppl...Work on microbes earns honors for two dental researchers
...r. Koo's work in this area helps us understand the pivotal role of nutrition in the development and prevention of dental decay," said Cyril Meyerowitz, D.D.S., M.S., chair of the Eastman Department of Dentistry and director of Eastman Dental Center. Marquis is a microbial physiologist who studies how bacteri...Key heart and Alzheimer's disease protein imaged for first time in native state
...to understand this molecule, since it plays such a pivotal role in both cardiovascular and neurological disease. X-ray crystallography is a technique for determining the three-dimensional structure of a molecule by analyzing the x-ray diffraction patterns of crystals that make up the molecule. "The next st...Nobelist discovers antidepressant protein in mouse brain
A protein that seems to be pivotal in lifting depression has been discovered by a Nobel Laureate researcher funded by the National Institutes of Health's National Institute of Mental Health (NIMH). "Mice deficient in this protein, called p11, display depression-like behaviors, while ...HHMI awards international research grants to 28 scientists
...third HHMI research grant. His first, in 1995, was pivotal in his decision to stay in Hungary despite prestigious job offers in the West. A second grant in 2000 enabled him to build a relatively large, well-equipped, internationally competitive lab. Now director of the Institute of Experimental Medicine of ...REVLIMID improves overall survival and delays disease progression in multiple myeloma patients
...announced updated clinical data from two Phase III pivotal studies evaluating REVLIMID (lenalidomide) plus de...eloma patients. The updated clinical data from the pivotal International Phase III trial (MM-010), demonstrated that the combination of REVLIMID plus dexametha...New data suggest pramipexole relieves symptoms of Restless Legs Syndrome (RLS) and is well-tolerated
...per day and up to 0.75mg single dose per day. Two pivotal studies of pramipexole in RLS have showed significant short- and long-term efficacy versus placebo. These and other trials are part of a comprehensive clinical trial program, involving more than 1,000 patients, to assess the therapeutic potential of...AutovaxID-C introduced by Biovest International
...'s lymphoma, BiovaxIDTM, is currently in a Phase 3 pivotal clinical trial at over 20 major centers in the US being conducted under a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute. For further information, please visit Biovest's website: www.biovest.com...AutovaxID-C introduced by Accentia Biopharmaceuticals
...ovest International, Inc. and it is currently in a pivotal Phase 3 clinical trial started by the National Can...'s lymphoma, BiovaxID TM , is currently in Phase 3 pivotal clinical trial at over 20 major centers in the US being conducted under a Cooperative Research and D...Biovest International announces that it will report new follow-up data
...non-Hodgkin's lymphoma is currently in a Phase III pivotal clinical trial at over 20 major centers in the US being conducted under a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute. For further information, please visit Biovest's website: www.biovest.com...Washington University receives $29.5 million to sequence corn genome
...us of ongoing plant genetics research and played a pivotal role in the development of a critical concept of modern genetics. Barbara McClintock, the 1983 winner of the Nobel Prize in Physiology or Medicine, discovered transposons, segments of genetic code that can jump from place to place in DNA, while study...Proteins take on new roles in malaria parasite
... "We identified one Plasmodium complex that may be pivotal for a better understanding of the mechanism of action of drugs that treat malaria and provide protein targets for new pharmaceuticals," said Sittler....New ECCO 13 data emphasise vital importance of cervical cancer detection, treatment and prevention
...eline prevalence of Pap smear abnormalities in two pivotal clinical trials of this vaccine were revealed at ECCO. Overall, in this multi-ethnic, geographically diverse study population of 17,926 young women from Europe, Latin and North American and the Asia-Pacific region, with an average age of 20 years, ab...... disease following induction therapy, according to pivotal phase III research presented this week at the annual meeting of the American College of Gastroenterology. The study, entitled PRECiSE 2, found that a significantly higher proportion of patients who responded to an induction regimen of 400 mg Cimzia a...Pall Corporation presents approach for speeding vaccine production to Shanghai conference
...that efficiently process larger volumes can play a pivotal role in moving the majority of vaccines from clinical trial to full-scale manufacturing." Sellick demonstrated the higher binding capacity of single-use Mustang TM membrane capsules for large molecule applications compared to conventional resin- or ...FSU biologists describe key role of signal-transcribing gene during cell cycle
...sts at Florida State University have uncovered the pivotal role of a gene called "Cut" that acts as a sort of middleman in cell-to-cell communication. A DNA-binding protein, Cut interprets and transcribes the developmental signals sent through the "Notch" gene, which regulates a layer of epithelial cells as ......nd Vincent Y. Wang, demonstrate that Math1 plays a pivotal role in the formation of many of the neurons important in carrying hearing and vestibular and balance signals after they have been received and transmitted by the inner ear hair cells. The gene also specifies neurons that coordinate balance of body ...