Wolves gone, western ecosystems suffer
...ation by top carnivores, especially wolves, may be pivotal to maintaining biodiversity in some ecosystems. More information on this research can be found on the Web at www.cof.orst.edu/wolves "The ranges of large carnivores are continuing to collapse around the world," the scientists note in...Researchers discover direct link between agricultural runoff and massive algal blooms in the sea
...cultural runoff from the Mississippi River plays a pivotal role in creating this annual dead zone, which measured 8,500 square miles (22,000 square kilometers) in 2002-an area bigger than the state of Massachusetts. "In the Sea of Cortez, there's the possibility that hypoxia could occur at a local scale, whi...Abundance of myostatin in infected swine may result in reduced muscle mass
...n the way for other infectious agents. During the pivotal growing stage, pigs are at the most risk and suffer from cough, fevers and depressed appetite. Reduced market weight or increased time for pigs to reach a desired market weight can be a substantial cost to producers. Infection from the bacterium ...Study identifies molecular complex vital to creation of miRNAs
...uggesting that miRNA activity or its lack may be pivotal in the disease process of that multifaceted disorder." The genes that code for miRNAs initially gives rise to a long primary RNA molecule that must first be cut into small precursor RNA molecules before final processing into mature miRNAs. The finish...Safety and immunogenicity data available for new pertussis booster vaccine candidate for adolescents
...mithKline (NYSE:GSK) today reported results from a pivotal clinical study of its booster vaccine candidate, Boostrix TM [Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed (Tdap)]. The Phase III clinical trial involved over 4,000 adolescents in the United States and showed ...Novartis receives European marketing authorization for Emselex(R)
...6 were treated with darifenacin. Across a range of pivotal endpoints, Emselex has been shown to significantly improve all other key symptoms of OAB, including the number of times patients had to visit the bathroom each day, bladder capacity, frequency of urgency, severity of urgency and number of incontinenc...Biological importance of basal activity of appetite suppressor
...ppression, even in the absence of a-MHC. Given its pivotal role in energy homeostasis, MC4R is considered a viable therapeutic target for combat-ing obesity. The parts of the MC4R protein that is required for a-MHC activation are well known, but those required for its constitutive activity and the biologic i...Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection
... confidence as we actively enroll and initiate our pivotal trial." The effects of AMG 162 (at 60 mg twice yea...The company recently announced the initiation of a pivotal Phase 3 study of AMG 162 in postmenopausal women with osteoporosis. Ongoing investigations of AMG 1...