Gladstone scientists announce new version of bioinformatics software program
...formation. As GenMAPP developer Bruce Conklin, MD, points out, a single genomics experiment can yield enough data to fill a large telephone book, and methods for organizing and analyzing the data are desperately needed. "Genomic experiments can easily overwhelm a scientist with data," explained Conklin, an ...DOE JGI launches IMG public online microbial genome data clearinghouse
...which targets the use of DNA sequences as starting points for systematically tackling questions about the essential processes of living systems. Andersen is exploring the potential of a particular microbe, Caulobacter crescentus, for heavy-metal remediation in wastewater. "I have found the IMG system very...Gene therapy cures inherited liver disease in rats
...e part of the cell where detoxification occurs. It points the way to using gene therapy to cure and/or treat a host of other disease that occur because of the lack of genes in this area of the cell. The viral vector itself is important because it has no long term effect. It does not become part of the gene...Researchers develop mouse model for studying blinding diseases in humans
...ays of the disease presentation and therefore many points to intervene in the disease process," he said. Patients with Stargardt disease typically begin showing symptoms of vision loss between the ages of 10 and 20. While Zhang doesn't expect new treatments to restore vision that has already been lost, he ...Light therapy may combat fungal infections, new evidence suggests
...with the normal fungus died by day 30. The finding points to novel virulence pathways, Heitman said, as the BWC1 and BWC2 mutants were not impaired for any of the characteristics previously linked to virulence. "The genes required for light sensing, while not essential for virulence, do contribute to the ra...Two UCSF scientists receive top funding honor from medical institute
...senger RNA on the path toward producing a protein, points to numerous new potential targets for drug and vaccine therapy. An outspoken advocate of making scientific findings freely accessible to scientists around the world, many of whom cannot afford to subscribe to scientific journals, DeRisi published his...Fish oil holds promise in Alzheimer's fight
... said that unlike many studies with mice, this one points to the benefits of a therapy that is easily available and already touted for other medical conditions. DHA--either from food sources such as fish and soy, or in fish-oil supplements--is recommended by many cardiologists for heart health, based on sc...Gene variations explain drug dose required to control seizures
...rs and drug metabolizing enzymes are good starting points for understanding variation among patients in drug response." In Parkinson's disease, for example, a pharmacogenetic test might assist physicians in prescribing the drug dose that will balance short-term control of tremors with long-term drug side ef...BRCA1 causes ovarian cancer through indirect, biochemical route
...hat's what makes this finding so exciting." Dubeau points out that women with BRCA1 mutations are also predisposed to cancers of the fallopian tubes, and that the mice with mutated BRCA1 genes in their granulosa cells developed tumors there as well. "This not only underscores the relevance of our mouse mode...Sea skate experiment sheds light on human cell transport
...ncer cells," Goldstein said. "If so, this research points up an important area for future research."...Separate genes influence speed, accuracy in decoding written words in dyslexia
...ychiatry, is noteworthy for two reasons. First, it points to a new location containing genes that contribute...d and not accuracy in decoding. They said evidence points to a possible combination of genes on chromosomes 2, 10 and 11 affecting speed. The researchers foc...JCI table of contents April 1, 2005
...mmentary, Gary Kammer of Arthritis Associates, Inc points out "the contribution by Tsokos and his colleaguesprovides a new appreciation and insight into how the microenvironment in lupus can further impinge on a defective T cell to inhibit IL-2 production. From such studies will come the inspiration and no......mmentary, Gary Kammer of Arthritis Associates, Inc points out "the contribution by Tsokos and his colleaguesprovides a new appreciation and insight into how the microenvironment in lupus can further impinge on a defective T cell to inhibit IL-2 production. From such studies will come the inspiration and no...Understanding natural killers could lead to new hepatitis treatments
...atitis. "So, all the evidence we can obtain so far points to CXCR6 being involved in promoting survival of these NKT cells when they get into the environment of the liver, and that's how the cells tend to accumulate there," said Littman. "Our data don't support a critical role of CXCR6 in crawling behavior ...Researchers pioneer new gene therapy technique using natural repair process
...e enzyme that recognizes and binds DNA at specific points into human immune cells harboring the mutant IL-2R gene. Once bound to the mutant gene, the enzyme creates a break in the DNA sequence, initiating the recombination process. In SCID, as well as many other diseases, both copies of the disease gene a...Vitamins, foods might improve your genes
...t-selling nutrition and health author Jack Challem points out that certain vitamins and foods enable your genes to function at their best. For example, at least one-third of Americans have a variation in the gene that reduces activity of folic acid, a B vitamin. As a result, they are more likely to heart di...Alcohol consumption disrupts breastfeeding hormones
...drink alcohol while breastfeeding. But as Mennella points out, "There was no valid scientific evidence to support this claim." To address this research deficit, the current study, reported in the April 2005 issue of the Journal of Clinical Endocrinology and Metabolism, is the first to analyze the effects ...UB conference to gather leaders in 'computational anatomy'
...the underlying spatial relations are required," he points out. "The workshop at UB is designed to contribute to the development of such theories, from the side of both bio- and spatial informatics." Attending the workshop will be some of the most prominent figures in the field, both nationally and inter...Clearing the air on airplane cabin air
...ency Particulate Air) filters. However, Lundquist points out that not all filters used by aircraft, even some designated HEPA, provide the highest level of microbial removal efficiency available today. In order to prevent the dissemination of infectious diseases, the filters must be able to stop microbes o......les to warm. The sea temperature pattern we found points the finger squarely at CO2 rather than the ocean currents. This is a real breakthrough for those of us investigating past climate we've made a major contribution to a long standing argument and our findings are critical to understanding how climate...