Common household fragrances may be harming aquatic wildlife, study finds
...iochemical process that allows cells to get rid of poisons and other foreign substances. "This is the first line of defense used by all cells," said Epel, the Jane and Marshall Steel Jr. Professor of Marine Sciences. "It consists of a special protein, called an efflux transporter, that's embedded in the cel...Researchers call for studies on role of BRCA1 mutations in chemotherapy response
...gests that BRCA1 function is necessary for spindle poisons to work. The authors recommend that prospective studies be conducted to evaluate BRCA1 expression and chemotherapeutic response and discuss several issues that should be considered when designing appropriate clinical trials. "By these approaches, it ...Development of portable infectious disease detector
...akes it possible to detect the presence of unknown poisons as long as they affect cell metabolism. Furthermore, by examining the impact that an unknown agent has on different cell types--such as heart, lung, nerve, skin, etc.--this approach also can rapidly provide critical insights into its mode of action. ...Source of molecular triggers in cutaneous T cell lymphoma identified
...gens and target the malignant cells with selective poisons delivered through the vehicle of LC." The study also showed that CTCL cells, after stimulation by LC, become functioning regulatory T (Treg) cells that suppress the immune responses of normal T cells to microbial agents. This may explain the suscepti...Small worm yields big clue on muscle receptor action
...own to be sensitive to levamisole, a chemical that poisons nematodes. Two additional receptor subunits -- ACR-16 and ACR-8 -- identified using Vanderbilt's data, were found to be likely candidates for the remaining acetylcholine response. ACR-16 was singled out as the key subunit. "We've shown the ACR-16-con...Humble yeast sheds light on promising anti-cancer drug
...e GSAO is not a conventional "cytotoxic" drug that poisons cancer cells, it does not cause unpleasant side effects such as nausea and hair loss. Small blood vessels consist primarily of endothelial cells that line their interior. They are genetically stable, in contrast to tumour cells that are inherently un...Innovative research set to push boundaries of cancer care
...modular approach and searched for topoisomerase II poisons that could circumvent transport proteins efflux, hypothesizing that this will allow entry into both the blood-brain barrier and glioma tumor cells. Out of 400 DNA binding agents, they selected two compounds for evaluation in vivo. Both of these comp...Modern technology helps shed light on illnesses in artists of the past
...e. Distilled from plants such as wormwood, thujone poisons the nervous system. The chemical effects of digitalis and thujone, which results in yellow vision, are now known. A modern clinical chemistry laboratory would have identified high levels of serum digitalis concentration and serum thujone concentratio...Newly discovered small molecules
...ficacy." Botulinum neurotoxins are the most lethal poisons known. They produce progressive paralysis by binding to nerves at the point where they connect to muscles, and blocking the release of acetylcholine, which signals the muscles to contract, including those that regulate breathing. Blocking the nerve s...Separate genetic mutations gave people, chimps bitter-taste sensitivity
...so that they were no longer pressured to taste the poisons found in those plants. But it also could be from a change in chimp behavior, such as a change in diet choice, Wooding said. "Different mutations in humans and chimps might have emerged for different reasons," he said, "but in both cases we think what...Invasive species harms native hardwoods by killing soil fungus
... growth, implying that the weed uses phytochemical poisons to disrupt native plants' mycorrhizal associations and stunt their growth. When the study was subsequently replicated with seedlings of 16 other native plants, only the hardwoods and other woody plants were harmed by the presence of garlic mustard. ...ACS weekly press package May 8, 2006
...eports decreased consumption of key nutrients The poisons within: a new focus for toxicology Electrifying ...818 Email: priorronaldl@uams.edu ARTICLE #2 The poisons within: a new focus for toxicology Chemical Research in Toxicology Every Crime Scene Investigation ...Harmful Algal Blooms monitored from space in Chile
...oms, which occur when some algae species producing poisons bloom rapidly in water, causing physical or biochemical damage to fish and shellfish. Early detection of Harmful Algal Blooms (HABs) allows fish farmers to make timely key decisions in order to minimise the damage to aquaculture. To aid in this effo...ACS Weekly PressPac -- July 12, 2006
... In addition to serious acute symptoms, ciguatoxin poisons often cause long-lasting neurological problems. The advance, by Masayuki Inoue, Masahiro Hirama and colleagues, means that a more abundant supply of ciguatoxin will be available for drug development and other research. In a report scheduled for the...Researchers find 'zip code' spurs cargo transport in neurons
...med at repairing synapses damaged by disease or by poisons such as lead. Scientists could use the tag as a research tool to help them better understand nerve cell transport. It might also be also be used in diagnostic studies to determine whether and how much transport has been affected by dementia or to tra...Wheat can fatally starve insect predators
...expect the plant to fortify its cell walls or make poisons to use against insects and pathogens." Instead, ...t cost the plant much to produce, unlike producing poisons and stronger walls. Those inducible defenses use a lot of a plant's energy that could be used toward...Nonvenomous Asian snakes 'borrow' defensive poison from toxic toads
...ands. When under attack, the snakes re-release the poisons from these neck glands. Many invertebrates sequester dietary toxins for use in defense, including milkweed insects and sea slugs. But vertebrate examples of toxin sequestration, especially from vertebrate prey, are rare. "A snake that's dependent o...Biodesign Institute takes part in $14.4M NIH chemical defense grant
...osis. "If we can catalytically neutralize these poisons using BChE or PON1, the real advantage will be that we won't need as much of the enzymes," said Mor. "Plus, there may be benefits to conditions such as heart disease through gaining an increased knowledge of how BChE works to clear potentially harmfu...Scientists find genes involved in the battle between Hessian flies and wheat
...hin the Hessian fly larval digestive system. These poisons then disrupt the insects' gut function. "The larvae probe the plant to open a sustained feeding site," said Jonathan Neal, a Purdue entomologist and another author of the paper. "Resistant plants block the larvae from establishing a feeding site. I...Tiny tweezers and yeast help St. Jude show how cancer drug works
...strands. Researchers already knew that topotecan poisons topoisomerase by binding to both the enzyme and to the nicked, single strand of DNA. This traps topoisomerase in place, turning the topotecan-topoisomerase-DNA complex into a roadblock that prevents the replication fork from advancing. Until now c...