Tag: "polycystic" at biology news
Female gender provides an advantage in renal diseases
...d progression rate of many renal diseases, such as polycystic
kidney disease (PKD). The physiology behind gender differences and renal disease is still uncertain, but the distinct characteristics of male and female kidney size, along with diet and the presence of hypertension, have all been thought to play a pa...
First baby is born after oocytes were matured in the lab and frozen
... The baby girl was born to one of 20 patients with polycystic
ovarian syndrome (PCOS) or with ovaries that had been detected to be polycystic
by ultrasound (U/S), who took part in the trial at McGill Reproductive Center, Montreal, Canada. The...
Scientists find new agent to fight genetic disorders -- Zorro-Locked Nucleic Acid
...e: Huntingtons disease, familial high cholesterol, polycystic
kidney disease, some instances of glaucoma and colorectal cancer, and neurofibromatosis, among others. "Zorro-LNA is a new substance that targets DNA and turns off genes," said co-author Edvard Smith of the Karolinska Institute in Sweden. "It has ...
Chinese medicinal compound stops formation of cysts in polycystic kidney disease in lab
...ion of kidney-destroying cysts in a mouse model of polycystic
kidney disease. This ability holds out hope for wh...study, with mice bred to have a disease like human polycystic
kidney disease, used triptolide with a less toxic concentration than that used in cancer chemotherap...
Link between beef consumption during pregnancy and reduced sperm quality in sons
...aternal beef consumption to daughters incidence of polycystic
ovarian syndrome, age at puberty and postnatal growth rate would be predicted to show a significant relationship," he said. Growth promoters for cattle, such as the synthetic hormone diethylstilbestrol (DES), have been used in the USA since 1954. A...
Triptolide: A potential drug for polycystic kidney disease
New Haven, Conn. A treatment for polycystic
kidney disease (PKD), a leading cause of fatal kidney failure worldwide, has been identified by a research team led by Yale biochemist Craig Crews , according to a report in the Proceedings of the National Academy of Sciences. Over 12 million peop...
Standard therapy more effective than diabetes drug in helping women with PCOS achieve pregnancy
...mise in overcoming the infertility associated with polycystic
ovary syndrome (PCOS), is less effective than the standard fertility drug treatment, clomiphene, according to researchers from the University of Pennsylvania School of Medicine and the National Institutes of Health Reproductive Medicine research netw...
Yale Cell Biologist Joel Rosenbaum, to receive Prestigious Wilson Award
... one of the most prevalent of human diseases, PKD, polycystic
kidney disease, forms of which can affect as many ...h was defective in the then-current mouse model of polycystic
kidney disease (PKD). The relationship between an IFT particle gene that would block flagella asse...
Hopkins develops online tool to aid research on certain 'orphan diseases'
...is a broad spectrum of human disorders - including polycystic
kidney disease and left-right axis defects, for example - that share similar clinical problems and cilia malfunctions," says Katsanis. Cilia are organelles whose main function was once thought confined to helping one-celled organisms propel themsel...
Genetic research at Children's Hospital of Pittsburgh reinforces theory of evolution
...of genes that did have a function, namely to cause polycystic
kidney disease and a bone disease known as osteoge...s of discovering the genetic mechanism that causes polycystic
kidney disease and osteogenesis imperfecta in the mouse model, according to Dr. Nicholls. ...
Polycystic kidney disease: MRI provides an early alert to progression
... and urine tests in people with autosomal dominant polycystic
kidney disease (PKD), according to a study funded by the National Institutes of Health (NIH). PKD is a common inherited condition characterized by cysts that grossly distort the kidneys and liver and by high blood pressure and brain aneurysms (bulge...
Scientists solve 30-year-old mystery of mutant mouse's kidney woes
...ly assumed that the mutation was causing a form of polycystic
kidney disease, but a follow-up study more than a decade later showed that passage of urine from the kidney was blocked, and the condition was renamed congenital progressive hydronephrosis. With assistance from the mouse genome sequence and Li Ding,...
Scientists discover that widely available drug also helps fight kidney disease
...sease known as ADPKD, short for autosomal-dominant polycystic
kidney disease. In the U.S., the number of individ...ur rapamycin-treated patients and found that their polycystic
kidneys shrank in size by 25% over two years. The polycystic
kidneys in a control group showed no ch...
A new way of looking at molecular motors
...ing retinitis pigmentosa (which causes blindness), polycystic
kidney disease, brain development defects, neurodegenerative diseases, muscular dystrophy, skin pigmentation problems, and genetic hearing loss. Researchers led by Dominique Soldati, a Howard Hughes Medical Institute (HHMI) international research sc...
Scientists find genetic pathway that could lead to drugs for kidney disease
...sease known as ADPKD, short for autosomal-dominant polycystic
kidney disease. In the U.S. this is more than the ...es. It is the loss of cilia function that leads to polycystic
kidneys. "With polycystic
kidneys, these tubular cells think they have to repair an injury, and the...
Keeping biological tubes in check: New insights into tube size morphogenesis
.... Several devastating pathological conditions like polycystic
kidney disease and ischemias have been intimately linked to the aberrant sizes of tubular organs. Yet the underlying cellular and molecular mechanisms that control tube size are poorly understood, and, consequently, drugs that intervene in tubular or...
Sept/Oct 2005 Annals of Family Medicine tip sheet
...drug used for the treatment of type 2 diabetes and polycystic
ovary syndrome, as treatment of overweight or obese adults who do not have diabetes or polycystic
ovary syndrome. Metformin as Treatment for Overweight and Obese Adults: a Systematic Review By ...
Newly identified enzyme group converts protein into cellular traffic signal
... has future implications for conditions -- such as polycystic
kidney disease, male infertility, behavioral disorders and cancer -- that involve defects in protein fibers called microtubules. The findings will be published in the online journal Science Express on May 12, 2005. The team was co-led by Jacek Gaerti...
Research shows smoking adds a decade to reproductive age of IVF patients
...ned fertility, and other causes (mainly women with polycystic
ovarian syndrome or endometriosis) and analysed first cycle treatment results for the first three causes. Of the total, 1,828 of the first IVF treatment cycles were for unexplained subfertility. The overall live birth rate per cycle was 15.2%. It...
Scientists analyze chromosomes 2 and 4
...ecause it holds the gene for Huntington's disease, polycystic
kidney disease, a form of muscular dystrophy and a variety of other inherited disorders. Chromosome 2 is noteworthy for being the second largest human chromosome, trailing only chromosome 1 in size. It is also home to the gene with the longest known,...