University of Pittsburgh scientists find new contributor to aggressive cancers
... rate. This suggests that this protein is a fairly potent tumor suppressor, said Dr. Luo. Dr. Luo and his coworkers then investigated the role of integrin 7 in metastasis by examining the relationship between the level of integrin 7 expression and cell migration by increasing the expression of normal inte...Nexavar significantly extends overall survival by 44 percent in liver cancer patients
...bust ongoing clinical program that could bring the potent cancer fighting properties of this oral multi-kinase inhibitor to an even broader number of patients in the coming years....An apple peel a day might keep cancer at bay
... literature. "We found that several compounds have potent anti-proliferative activities against human liver,...of the anti-cancer work. "Some compounds were more potent and acted differently against the various cancer cell lines, but they all show very potent anti-canc...Soils offer new hope as carbon sink
...ous oxide (a greenhouse gas more than 300 times as potent as carbon dioxide). NSW DPI environmental scientist Steve Kimber said an added benefit for both the farmer who applies agrichar and the environment is that the carbon in agrichar remains locked up in the soil for many years longer than, for example,...JCI table of contents: May 24, 2007
...tin physiology by showing that resistin exerts its potent actions on the liver partly via its action within the hypothalamus. Secondly, resistin exerts proinflammatory influence on the liver through both peripheral and central mechanisms. The authors suggest that the action of resistin in the hypothalamus m...Engineered protein effective against Staphylococcus aureus toxin
...is listed as a potential bioterrorism agent. Other potent S. aureus enterotoxins include the toxic shock syndrome toxin. These enterotoxins are classed as superantigens because they set off a massive immune response in humans and other animals. They bind to variable regions of T-cell receptors, stimulati...Combining NSAIDs with chemotherapy, radiation may improve cancer treatment
...o new UI studies show that the NSAID celecoxib has potent anticancer activity, which is associated with the drug's ability to disrupt the cell cycle -- the orderly, multi-step process by which cells divide. In particular, the experiments showed that celecoxib specifically kills head and neck cancer cells...Soy estrogens and breast cancer: Researcher offers overview
... 2002 and 2003. While purified genistein is not as potent as HRT, Helferich said, it still poses a risk to midlife women because the amount consumed is much higher. The labels of many products that contain this and other isoflavones lack vital information about what is actually in their products, he said, a...Other highlights in the May 16 JNCI
...r used in trials in the adjuvant setting, but more potent bisphosphonates should be investigated," the autho...t in length or quality of life using high doses of potent intravenous bisphosphonates does not rule out the possibility that no benefit exists," the authors w...Burroughs Wellcome Fund awards $14M to support physician-scientists
...d University Design and characterization of highly potent inhibitors of HDAC6 Clark C. Chen, M.D., Ph.D. Harvard Medical School The molecular basis and therapeutic implications of genome instability during brain tumor progression Arlene Dent, M.D., Ph.D. Case Western Reserve University Acquisition o...ACS News Service Weekly PressPac -- May 2, 2007
...dizes during exposure to air, changing into a more potent allergen. "Cases of allergy to the oxidation products of geraniol will not be diagnosed unless patients are tested with the air-exposed material," the report states. "Thus, our observations once more emphasize the need for testing with the right mate...Lonesome George is not alone among Galpagos tortoises
...ch for a mate have positioned Lonesome George as a potent conservation icon, not just for the Galpagos, but worldwide. In the new work, Dr. Michael Russello (presently at the University of British Columbia Okanagan), Dr. Adalgisa Caccone, Dr. Jeffrey Powell, and colleagues, with the strong support and coo...Famous Galpagos tortoise, Lonesome George, may not be alone
...rch for a mate has positioned Lonesome George as a potent conservation icon, not just for Galpagos, but worldwide." Although Lonesome George has yet to find a tortoise partner, upwards of 50,000 people visit him each year. The study, published in Current Biology, gives a peek into the evolutionary history...Reversing cancer cells to normal cells
...testicular cancer) regain the ability to express a potent embryonic morphogen like Nodal, the presence of the Nodal and the signals it sends and receives appear to play a key role in tumor cell plasticity and progression. Most noteworthy, Dr. Hendrixs teams also has shown that inhibition of Nodal signal......t terrestrial plants may be a global source of the potent greenhouse gas methane, making plants substantial contributors to the annual global methane budget. This controversial finding and the resulting commotion triggered a consortium (2) of Dutch scientists to re-examine this in an independent study. Repo...Arming the fight against resistant bacteria
...al activity comparable to that of some of the most potent antibiotics currently available. Their findings ... promising is their finding that, while their most potent compounds were able to kill several clinically relevant bacterial strains, the strongest activity wa...2-protein team would be lost without each other
...Short-root. It actively binds to and restrains the potent Short-root to the endodermis layer, where the waterproofing layer is established. The endodermis is a ring of cells interspersed with a waterproofing material that is arranged like the mortar between bricks. The cells function much like kidneys, filt...OHSU lab finds meth receptor that could lead to therapy
... clear evidence that methamphetamine is a full and potent agonist of TAAR1. In other words, TAAR1 has the necessary features to be considered a real target of methamphetamine and amphetamine in rodents and probably humans, too." Grandy added that it's his hope that "these findings will eventually lead to ...3 proteins may play important role in nerve-cell repair
...ndant in the nerve cells, while GPR12 was the most potent at stimulating growth of the nerve extensions. The study showed that blocking GPR3 greatly slows the growth of the nerve extensions. The researchers reversed this effect by restoring either GPR3 or GPR12 in the cells. High levels of the three prot...Massive gene screening points way to more effective chemotherapy
...dentifying genes that make chemotherapy drugs more potent at lower doses is a first step toward alleviating these effects in patients." The current study tested only isolated cancer cells, so further studies will be needed to determine whether blocking the genes in living animals has the same effect. T...