Cloning techniques produce FDA-approved antibiotic
...fomycin in a cost-effective manner and create more potent derivatives of it." Previously, four essential genes and a portion of fosfomycin's biosynthetic pathway had been proposed, but researchers were unable to produce fosfomycin in a non-native host. Zhao's findings indicate that the presence of additiona...Gene therapy for hereditary lung disease advances
... animal studies to be close to a thousandfold more potent at making protein," Flotte said. "That's very encouraging to us. So the next trial, which has already begun, is to use the new version of the virus and take patients through a similar range of doses, in a very similar scheme, and see if we can mainta...Chemical exchanges show wasps are bad losers
...hat it is always the losing wasp that releases the potent gas. While the research was primarily aimed at improving the understanding of animal behaviour, lead researcher Dr Ian Hardy, from the University of Nottingham, explains that there is great potential for applied spin-offs: "Bethylid wasps kill the ...A key antibody, IgG, links cells' capture and disposal of germs
... phagosomes that corral invading pathogens and the potent lysosomes that eventually kill off the germs. The research, by Axel Nohturfft at Harvard University and colleagues at Harvard, Massachusetts General Hospital, and the Massachusetts Institute of Technology, appears this week in the Proceedings of th...... effect," the researchers wrote. RgIA was such a potent pain reliever that "about 10 billionths of an ounce reversed the hypersensitivity to pain," McIntosh says. Vc1.1 had a similar effect replicating studies by other researchers allowing rats with sciatica to tolerate touch with greater pressure. ...Patients respond well to first study to test higher doses of an anti-cancer drug
...hybrid molecule specifically designed to deliver a potent cell-killing agent to cancer cells and is created by attaching a cytotoxic drug DM1 to a monoclonal antibody, huN901. It binds to cells that have the molecule CD56 on their cell surfaces and the DM1 then can kill the cells. Several tumours are CD5...ACS News Service Weekly PressPac -- Oct. 25, 2006
... of compounds, including one that is 15 times more potent than an approved drug now being tested in clinical trials. Their report is scheduled for the Nov. 2 issue of the biweekly ACS Journal of Medicinal Chemistry. Prions are infectious proteins that cause brain disorders like Mad Cow Disease and Creutzfe...Scientists discover two-component lantibiotic with therapeutic potential
...led lantibiotics. Lantibiotics are a class of very potent antimicrobial compounds whose antimicrobial properties are attributed to their structure. They possess unusual sulfur bridged rings that provide structural rigidity for binding their cellular targets. Lantibiotics are commonly used in the food indust...Interdisciplinary grant to Yale: Creating nanodevices for delivery of vaccines
...cognition and antigen modules for a broad-spectrum potent vaccine response....Circadian gene helps the brain predict mealtime
...ished by Cell Press. A daily scheduled meal is a potent time-giving cue that can reset the physiological timing of most organs, including the liver. In terms of animal behavior, a daily scheduled meal elicits anticipatory bouts of locomotor activity and changes in body temperature. These food-anticipatory...New biochip helps study living cells, may speed drug development
...arget sodium-channels. In nature, some of the most potent venoms and toxins work by blocking these channels, including the venom of certain snakes and strychnine. Porterfield's chip is technically classified as a "cell electrophysiology lab-on-a-chip." The device is further described in an article in the...Methane devourer discovered in the Arctic
...ane is an aggressive greenhouse gas, 25-times more potent than carbon dioxide. Fortunately, some specialised microorganisms feed on methane and thereby reduce emissions of this greenhouse gas. For the first time, a German-French research team showed which methane consuming microorganisms thrive in the ice-c...Tips from the journals of the American Society for Microbiology
...ed in the identification of a fully human MAb with potent activity in vivo and uncovered a previously unrecognized mechanism of antibody-mediated toxin neutralization that is important for currently used anthrax vaccines," say the researchers. (L. Vitale, D. Blanset, I. Lowy, T. O'Neill, J. Goldstein, S.F...Commonplace sugar compound silences seizures
... when healers sometimes prescribed starvation as a potent way to fend off seizures. UW-Madison researchers first began to investigate the role of sugar in controlling seizures after early experiments showed that children on sugar-free diets can rapidly experience seizures when they consume even a small d...Research holds promise for herpes vaccine
...y unable to cause disease, but is still remarkably potent as a vaccine," Halford said. In a human vaccine, the genetic instructions for ICP0 would actually be removed, creating an "attenuated," or weakened virus. The rest of the herpes simplex virus' genetic code would remain intact. Measles, mumps, rubel...Northern bogs may have helped kick-start past global warming
...for molecule, it is said to be up to 23 times more potent as a greenhouse gas than carbon dioxide. So while peatlands do sequester carbon, their methane emissions can offset any potential drop in greenhouse gases. Yet, the rate of emissions is not steady. "Newly formed peatlands are often typified by sys...Caterpillars tell us how bacteria cause disease
...ce genes, which ordinarily might be masked by more potent factors (when dealing with the whole bacterium), but by using insects instead it will also help reduce the number of mammals, such as rats and mice, needed in future genomics research. It also provides a safer method for researchers working with dang...Study could help transplant surgeons predict rejection/tailor medications
...s likely to reject could have lower doses, or less potent combinations," said Dr. Sindhi, an associate professor of surgery at the University of Pittsburgh School of Medicine. "By applying individualized anti-rejection strategies before the transplant even occurs, we hope to reduce rejection rates and drug-...Australian scientists have identified a highly potent toxin that causes severe gastrointestinal illnesses, including food poisoning. The toxin, produced by certain strains of E. coli bacteria, has been found to be responsible for an outbreak of haemolytic uraemic syndrome, a dangerous disease that ca...