US grant targets genes behind severe arthritis
... spondylitis was an expensive and lifelong bout of potent injections which suppressed the immune system. He said the grant, from the National Institute of Arthritis and Musculoskeletal and Skin Diseases in the US, not only raised awareness of the disease but also of Australianresearch know-how. "Because...AVELOX as effective as multi-dose combination therapy for intra-abdominal infections
...cal Center in Cleveland. "AVELOX has demonstrated potent activity against the bacteria most common in these infections and is a safe and effective treatment. It also can be continued as a once-daily tablet, which is convenient for patients." AVELOX is indicated to treat polymicrobial cIAI infections, in...New clues to how major weight-loss drugs work
...d on particular neurons in this circuitry that are potent modulators of food intake and body weight. What's more, the researchers found that both serotonin and drugs that affect serotonin's action acted on these neurons to reduce the release of a protein called AgRP that stimulates appetite and aid release ...Natural vitamin E tocotrienol reaches blood at protective levels
...t another natural form of vitamin E surfacing as a potent neuroprotective agent in repeated Ohio State University Medical Center studies is tocotrienol, or TCT. This form, while not abundant in the American diet, occurs naturally in palm oil; this vegetable oil is increasingly used in prepared foods beca...Researchers discover inhibitor of infection by HPV
Researchers have discovered a potent inhibitor of the human papilloma viruses (HPV), pa...cal HPV topical microbicide," Schiller said. "The potent inhibition of infection of cells in dishes, coupled with the fact that carrageenan-based products ar...Researchers link specific antibody presence to prevention of mother-to-baby HIV transmission
....5 percent). This suggests that the antibody has a potent protective or selective effect in perinatal HIV transmission. This study also found that the closest match to the transmitted virus to the baby was the mother's neutralization-escape virus. Impact: Further research into the protective role of th...AACR awards $2.6 million in grants for metastatic colon cancer research
...been shown to cause up-regulation of IL24 - a very potent anticancer protein. SC144 will be fully evaluated in mouse models and then, potentially, trials will be extended to humans. Boris C. Pasche, M.D., Ph.D., Northwestern University, "Targeting the TGFBR1*6A in Metastatic Colon Cancer." This study...U of I scientist develops enzyme inhibitor that may slow cancer growth
...cifically cancer treatment. "These chemicals are potent inhibitors of an enzyme called betaine-homocysteine-S-methyltransferase (BHMT)," said Garrow. "BHMT catalyzes a reaction that converts homocysteine to methionine. Because cancer cells require high levels of methionine, the ability to slow methionin...Yale licenses potential anti-HIV agent to Oncolys BioPharma of Japan
...gical studies have demonstrated that Ed4T has more potent anti-HIV activity than the existing NRTI and is active against those viruses that are resistant to the existing NRTI and NNRTI drugs. Further, Ed4T does not affect DNA synthesis in mitochondria, a toxic side effect of some nucleotide analogues. These...Mushrooms as good an antioxidant source as more colorful veggies
...nd in the latest study indicate that mushrooms are potent anti-oxidant sources. The research revealed that, of the mushrooms tested, portabella mushrooms and crimini mushrooms have the highest ORAC values. Criminis, which are brown, are otherwise similar to the popular white button mushroom, the one mostly ...New therapy may mean less dietary restrictions for celiac sufferers
...dy, the researchers went on to devise an even more potent double enzyme therapy for detoxifying gluten. EP-B2 was tested in combination with another well-characterized enzyme called PEP that breaks gluten protein after proline residues. Like glutamine, proline is also abundant in inflammatory gluten peptid...Baby girls born to mothers burdened by stress may be at risk for fibromyalgia
... womb to these synthetic hormones, which also have potent anti-inflammatory and immunosuppressive properties, can have life-long consequences. According to Dr. Matthews' research, exposure affects the hypothalamic-pituitary-adrenal axis (HPA), which controls how the body responds to stress and is involved i...Microbes transform 'safest' PBDEs into more harmful compounds
...p making and selling penta-BDEs and octa-BDEs, two potent forms of PBDEs linked to health problems in animals. Deca-BDE, the most commonly used form of PBDE, remains on the market because it is considered more stable and less readily absorbed into the body, Alvarez-Cohen says. Laboratory studies, however, h...Nilotinib appears to help chronic myelogenous leukemia patients when standard care fails
... administered in pill form, is up to 50 times more potent than Gleevec because it was designed to more efficiently bind to, and shut down, the protein enzyme responsible for the disease. The June 15 NEJM also includes a report on a phase 1 clinical trial for dasatinib, a medication developed by Bristol-Mye...Drug that battles resistance to leukemia pill Gleevec 'extremely effective' against cancer
...esistance, Sawyers said. It's about 300 times more potent than Gleevec as well. Over five years, about 20 percent of patients become resistant to Gleevec, Sawyers said. One of the reasons Sprycel works so well to combat that resistance is that it binds to the mutant proteins in a different way than Gleevec...Gene therapy injected into the brains' of mice with Huntington's disease
...ssion in newly diagnosed HD patients by delivering potent trophic factors with effects that are long-term and non-toxic." "If these results can be replicated in HD patients, it would represent a significant advance in the treatment of this tragic disease", agreed Dr. Jeffrey Ostrove, President and CEO of ...$1.7 million for Rutgers anti-HIV drug research
... HIV-infected cells, and to assist the delivery of potent anti-HIV drugs to areas of the body that are typically difficult to access, such as the brain. A limited number of the NIH MERIT (Method to Extend Research in Time) awards are made to investigators who have demonstrated superior competence and outsta...New treatment option breaks Leukemia's resistance to chemotherapy, radiation therapy
... "The targeted alpha particle therapy is much more potent than targeted beta particle therapy or external radiation therapy," said Friesen. Low doses of alpha particles cause a prompt and complete cell kill in sensitive and resistant tumor cells, researchers discovered. "Our work considerably expands therap...Hormone's role in insects could give insight for cancer treatment, malnutrition
...wth, "but we find in insects that they also have a potent hormone that inhibits growth of developing tissues." "Our paper is something of a wakeup call that there are hormones that repress growth, as well as those that stimulate it, and we should keep an eye out for them in other organisms, including oursel...Mice lacking key immune component still control chronic viral infections
... in order to create vaccines that trigger the most potent antiviral immune responses. "The ultimate relevance of these backup systems to human disease isn't known yet, but it's worth noting that we never would have even known to look for them if it weren't for our ability to study genetically altered mice,...