New drug may be formidable adversary for hard to treat leukemia
As scientists uncover the precise molecular mechanisms that underlie effective cancer treatments, they gain invaluable insight into why predominantly successful treatments fail for some patients. A new study published in the February issue of Cancer Cell reveals how detailed informa...Chemical analysis of mushrooms shows their nutritional benefits
...vitamins, unsaturated fatty acids and fiber, but a precise carbohydrate breakdown had been elusive. The mushrooms studied were white button, crimini and portabella, all of which represent different maturity levels of Agaricus bisporus, and maitake (Grifola frondosa), shiitake (Lentinus edodes) and enoki (Fla...Open microfluidic and nanofluidic systems
...well-defined geometry by which one can measure the precise amount of liquid contained in them; they should be able to confine variable amounts of liquid; and they should be accessible in such a way that one can add and extract liquid in a convenient manner. An appealing design principle for such microcompart...Mechanical tension helps shape lung development
Organ development in the embryo requires precise coordination and timing of cell growth in three-dimensional space to produce the correct anatomic form and shape. Researchers at Children's Hospital Boston, led by Dr. Donald Ingber, a senior researcher in the Vascular Biology Program, have demonstra...JCI table of contents March 1, 2005
... is a protein that helps lubricate joints, but its precise function there was unknown. Appearing online on February 17 in advance of publication in the March 1 print edition of the Journal of Clinical Investigation, Matthew Warman and colleagues from Case Western Reserve University created mice lacking lubr...Brain controls robot arm in monkey, University of Pittsburgh researcher reports at AAAS
...d brain devices with smooth, responsive and highly precise movement. They are now working to develop a prosthesis with realistic hand and finger movements. Because of the complexity of a human hand and the movements it needs to make, the researchers expect it to be a major challenge. Others involved in the r...Plants respond similarly to signals from friends, enemies
...and later galls or knots on it. "We don't know the precise structure of Nematode factor, but it appears that the nematodes may have actually acquired genes from rhizobia to exploit this signal pathway," Bird says....Urgent measures needed to retain our lead in pharmaceuticals
...genome project we now have the means to examine in precise detail the origins of genetic variation and relate this to disease susceptibility", he says. A project named Generation Scotland is being put forward to provide improved capacity for diagnosis and to develop and apply new treatment regimes. As a roun...Linking brain to mind in a common genetic disease
... as magnetic resonance imaging (MRI) to yield more precise measurements of structures in the living brain. MRI can provide images and compute volumes of anatomical features. In addition, by measuring how water diffuses in the brain, it indicates the layout of nerve fibers and suggests how brain areas are con...JCI table of contents April 1, 2005
...ppa B plays a role in this type of injury, but its precise function is unclear. In a study appearing online on March 17, in advance of the April 1 print edition of the Journal of Clinical Investigation , Christian Trautwein and colleagues from Hannover Medical School interfere with NF kappa B function in li...Joslin Diabetes Center scientists find genetic defects
...osomal regions involved and can now zero in on the precise genes," said Diane Mathis, Ph.D., the study's prin...regions are known, the researchers are seeking the precise genes involved. "Once these genes are identified, we will be better able to define the biologic path...Poplar trees redirect resources in response to simulated attack
...y allows for taking a snapshot in time showing the precise location of the radiotracer within the plant. With this and other techniques, the scientists can compare what that plant does with the carbon dioxide both before and after an attack. "Carbon dioxide is a plant's major resource. To see how it is alloc...Prominent North Shore-LIJ physician-researcher brings science to the masses with new book
...ly orchestrated battle inside the body fought with precise weapons that target the invaders and prevent their spread. In severe sepsis, for reasons that are still poorly known, the controls break down and the attack goes awry, unleashing the immune weapons in amounts that injure and kill surrounding normal c...JCI table of contents April 1, 2005
...y causative mutations. The researchers do find the precise mutation (a 21 base pair deletion) that was previously reported to be causative of CAD, but in this new JCI study, this mutation was found in three control subjects who did not have CAD or any other coronary heart disease. Thus, the studies demonstra...A change of heart for MEF2A in coronary artery disease
...y causative mutations. The researchers do find the precise mutation (a 21 base pair deletion) that was previously reported to be causative of CAD, but in this new JCI study, this mutation was found in three control subjects who did not have CAD or any other coronary heart disease. Thus, the studies demonstra...In asthma, it's not the drugs but the inflammation that increases cardiovascular risk, damage
...hma. And in the longer term, identification of the precise cause of cardiac changes induced by asthma and the appropriate therapeutic targets should provide better, specific alternatives for patients symptomatic for both asthma and cardiovascular disease, or CVD," Hazarika predicted. Study shows asthma "hel...New technique finds molecules necessary for cancer metastasis
...to inactivate specific proteins in living cells at precise times and locations. The researchers are able to destroy a specific protein, sparing all other proteins attached to the cell as well as the cell itself, by targeting the antibody to that specific cell. They tag the antibody with a dye that absorbs a ...New insight into brain and speech promises help for learning disabilities
...n sound will unfailingly induce a neuron to fire a precise number of milliseconds later. In a disordered system, however, the timing of these firings can vary markedly. "We record the averaged activity of large numbers of neurons," Kraus explains. "If the neurons are not firing when they should, the response...NJIT math professor helps navy detect subs; Explains global warming
...roducts of her research are special algorithms, or precise mathematical tools, that may eventually be applied in next-generation systems for protecting the shores of the U.S. against unauthorized underwater incursions. While national defense is a primary focus of Michalopoulou's ONR-funded research, her effo......pair stretch of DNA sequence that likely marks the precise location of the inactived centromere. That tract is characterized by a type of DNA duplication, known as alpha satellite repeats, that is a hallmark of centromeres. In addition, the tract is flanked by an unusual abundance of another type of DNA dupl...