JCI table of contents July 1, 2005
... overexpressed in hereditary hypertension, but its precise role in the disease was unclear. In a new study appearing in the July 1 print issue of The Journal of Clinical Investigation, Sushil Mahata and colleagues from UCSD describe several novel phenotypes observed in mice lacking CHGA, and establish a role...42 biomedical scientists worldwide named HHMI international research scholars
...s from infected red blood cells. Understanding the precise mechanisms of artemisinin action could lead to new targets for better drugs for treating malaria. Kamchonwongpaisan already is collaborating with two other HHMI international research scholars, Alan Cowman and Brendan Crabb, who do malaria research a...New study on OTC progesterone health risks in women published
...d from previous studies because of its use of more precise and advanced drug analysis methods, giving results that are accurate compared to previous studies with topical progesterone products. Given the risks associated with prolonged progesterone therapy, the researchers note with concern that women may be ...World-record magnet to pull in scientific breakthroughs
...entific research," Boebinger said. "The incredibly precise magnetic fields of the 900-megahertz magnet immediately position our chemistry and biology research programs at the forefront of magnetic resonance research -- research that will help us understand the workings of biological molecules, as well as the...Study explores plant phenotypic plasticity belowground
...ith which they forage, with grasses generally less precise foragers than broad-leafed plants. However, the ab...venly distributed, regardless of whether they were precise foragers or not. This research opens up new avenues of inquiry about the ecological significance of ...JCI Table of contents August 1, 2005
...human ageing-like phenotypes in mice. However, the precise function of beta Klotho has been unknown. In a new study appearing on August 1 in The Journal of Clinical Investigation, Yo-ichi Nabeshima and colleagues from Kyoto University generated and analyzed beta Klotho-null mice to investigate its function...Scientists discover genetic pathway responsible for breast cancer cell growth
...s, efforts can now be focused on developing a more precise cure/treatment for cancer based on this gene. "The problem with cancer drugs in general has been that they are often untargeted, which is why patients experience side effects," notes Dr. Gigure. "The more focused the drugs the less side effects and t...Infectious disease expert warns of spread of Rocky Mountain spotted fever
...build-up of fluid inside the lungs and brain. The precise origins of Rocky Mountain spotted fever are not known, but the disease is only known to occur in North and South America....Key process in gene regulation occurs in blood platelets, Univeristy of Utah researchers find
...a number of intricate ways the body maintains more precise control over gene expression. Many of these control mechanisms are just coming to light. Platelets are abundant cells that circulate in human blood and have many functions. Their primary role is to form "plugs" that stop bleeding from injured blood v...JCI table of contents September 1, 2005
... involved in various cellular processes, but their precise roles in vivo were not clear because genetic loss of Foxo function had diverse effects. In a study appearing online on August 11 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation, Stefanie Dimmeler and ...New gene associated with Fanconi anemia 'explains' hallmark chromosomal instability
...o FANCD2 -- are actually doing. "No one knows the precise role of any of these genes and proteins, but we believe that if BRCA1 or BRCA2, or any of the Fanconi genes that activate D2 are defective, a sequence of events is disrupted and DNA repair is blocked," she says. But Auerbach and her team of research...SciFinder 2006 launches powerful new substance search capablities
...options for identifying substances of interest via precise statistical analysis using the Tanimoto algorithm; Structure Query Tools - to identify substances more precisely, new tools permit drawing a variable attachment point and a repeating group; Reaction Searching - finding reaction information has be...Poaching, logging, and outbreaks of Ebola threaten central African gorillas and chimpanzees
...rsible. While the experts were unable to establish precise population figures for the gorillas and chimpanzees, they determined that recent Ebola outbreaks, bushmeat hunting and logging have almost wiped out some populations. The action plan noted that apes reproduce slowly, with limited capacity to recover ...Designed peptides: Candidates for the treatment of cancer, sexual dysfunction, eating disorders
...ical structure of the ligands in a slight but very precise way, they become 100 times more selective or 100 times more potent," said Hruby. In contrast to the melanotropins occurring in the body, which tend to degrade quickly, sometimes within seconds, the artificial ligands are more stable. This is a cruci...The 'been there, done that' memory response
...as magnetoencephalography (MEG), which reports the precise timing of brain responses. The technique of fMRI uses harmless magnetic fields and radio waves to map blood flow in the brain, which reflects brain activity, and MEG detects the infinitesimal magnetic fields generated by brain electrical activity. Th...Embryonic stem cells accrue genetic changes
...and understand these changes." At this point, the precise effects of these changes on the cells aren't known, but some of the changes resemble those seen in cancerous cells. At any rate, the changes presumably became entrenched in a particular cell line because they conferred some advantage as the cells wer...Chernobyl: The true scale of the accident
...ns that followed the break-up of the Soviet Union, precise costs have been impossible to calculate. A variety of estimates from the 1990s placed the costs over two decades at hundreds of billions of dollars. These costs included direct damage, expenditures related to recovery and mitigation, resettlement of ......ve and unique: it recognises finger positions in a precise way through a novel algorithm with just one camera. "Our final objective was to implement imitational learning on this artificial hand and to suggest applications of the new methods and models to other artefacts with many degrees of freedom that coop......Lahn and his colleagues are trying to find out the precise traits that are under natural selection. They are also performing more detailed studies of the two genes in human populations to better understand their evolutionary history. And they are searching for other brain-related genes that have changed unde...