National Academies news: Stem cell guidelines released
...lated genetically or transplanted into animals for preclinical testing. Donors also need to be told that although research involving their stem cells may have commercial potential, donors will not share in any financial benefit. Research on existing anonymous or coded embryonic stem cell lines does not require ...Scientists generate patient-specific stem cells, Science study says
...ntestinal and respiratory lining. One of the next preclinical steps, according to the authors, is to evaluate, in the lab, differentiated patient-specific human embryonic stem cell lines for immune-system tolerance, therapeutic efficacy and safety. Initial laboratory experiments showed immune system compatibili...Molecular miners find pain relief drugs from the sea
...s Limited recently announced successful results in preclinical trials of the toxin. The company will begin clinical trials in humans this month to firstly test the safety of the toxin in normal males, and later its effectiveness in treating the neuropathic pain associated with diabetes. From the University of M...Experts to explore genetics, therapies for connective tissue diseases at Jefferson
...art is now in research creating and studying such preclinical disease models." EB, he notes, is not especially common, but "has been very instructional in understanding the function of normal basement membranes." Basement membranes provide foundations for a variety of tissues, including forming a strong sheath ...Chemical Society announces EPA awards for environmentally friendly technologies
...ard D. Tillyer, senior vice president of worldwide preclinical development at Merck & Co., Inc., which is headquartered in Whitehouse Station, N.J., will accept the award. Substituting cellulose for petroleum in some plastic products A University of Alabama research team used an abundant, renewable resource ...Targacept compounds show long-lasting improvement in cognition
...nt in the central nervous system. For example, in preclinical animal studies, Targacept's compounds TC-1827 and TC-1734 improved cognitive performance for up to 15 and 18 hours, respectively, though the compounds were appreciably metabolized and eliminated in less than an hour. The authors postulate that the c...OT, VP studied as novel psychiatric drug sources; consider gender-specific drug models
...c disorders, evidence is beginning to emerge "from preclinical animal models that point to the important role of oxytocin in the neurophysiology underlying anxiety and schizophrenia." Specific research from Wyeth, presented by Ring at the APS meeting this week, suggests that drugs might be developed to regulate...Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels
...ed metabolic disease program, Galileo confirmed in preclinical models that inhibiting lipoxygenases, known mediat...ipoxygenase inhibitors that have shown activity in preclinical animal models of diabetes and are evaluating more potent and pharmacologically optimized leads in ap...VIB signs cooperation agreement for the development of a new, universal flu vaccine
...ks out. This innovative vaccine is currently in a preclinical phase. It is not longer produced by the growth of viruses, but the active component is produced in bacteria. Therefore the production process will be more effective, safer and cheaper. Walter Fiers, co-inventor (UGent and VIB): 'The structure o......chnologies and/or innovative approaches to develop preclinical models to understand metastases....New imaging technology shown to detect pancreatic inflammation in type 1 diabetes
...s may one day be able to identify individuals with preclinical type 1 diabetes, and to assess the effectiveness of therapies much earlier than is now possible. Findings of the study will be published in the September issue of the Journal of Clinical Investigation. Type 1 diabetes is an autoimmune disease in whic...JCI table of contents September 1, 2005
...with therapy. This new imaging strategy provides preclinical data on mouse models of Type-1 diabetes that can guide the application of an in vivo MRI technique to patients with autoimmune diabetes. Title: Seeing autoimmunity - noninvasive imaging of type 1 diabetes and its reversal AUTHOR CONTACT: Diane M...Looking at autoimmune diabetes, literally
...with therapy. This new imaging strategy provides preclinical data on mouse models of Type-1 diabetes that can guide the application of an in vivo MRI technique to patients with autoimmune diabetes....Inaugural meeting of Oligonucleotide Therapeutics Society highlights RNAi & antisense
...ill suggest how basic science, drug discovery, and preclinical and clinical research can be integrated and survey...fication and validation of targets and systems for preclinical studies novel oligonucleotides derivatives clinical studies and industry-driven therapeutic stra...New vaccine protects more effectively against tuberculosis
...gainst pulmonary tuberculosis has been achieved in preclinical studies. Importantly, the new vaccine also protects against clinical isolates of the Beijing family. These clinical isolates are frequently multi-drug-resistant and more aggressive and hence have started to conquer the globe. It has been assumed that...JCI table of contents October 1, 2005
...mechanism of action of the drug was not clear from preclinical studies or from other similar agents. In a paper appearing online on September 15 in advance of print publication of the October 1 issue of the Journal of Clinical Investigation, Kevan Herold and colleagues from Columbia University investigate how th...Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease
...uthor, which demonstrated, for the first time in a preclinical model, that AAV could be a safe and effective vehicle for gene therapy in the brain. Most importantly, AAV has never been associated with any human disease. According to Drs. Kaplitt and During, "The goal of this research is to determine whether we ...NHLBI funds new centers for cell-based therapy
...nment. Many of the 5-year studies will begin with preclinical animal or laboratory research to support an Investigational New Drug Application submission to the FDA followed by Phase I and II clinical studies for safety and effectiveness, respectively. The centers awarded the grants and the principal investigat...Chemical Biology & Drug Design. A new face, a new title, a new vision
...mistry with biology and drug design to establish a preclinical engine for advancing novel small-molecule lead compounds. Tomi is also Adjunct Professor at both the University of Massachusetts (Departments of Chemistry and Biochemistry & Molecular Biology) and the University of Massachusetts Medical School (Depa...... related commentary, write, "These studies provide preclinical proof of concept for the clinical development of a PDGF inhibitor as a targeted therapy for pulmonary arterial hypertension patients." TITLE: Reversal of experimental pulmonary hypertension by platelet derived growth factor inhibition AUTHOR CONTA...