Over the edge: New therapeutic strategy takes advantage of stressed cancer cells
...chieve such activity in vitro and in vivo. Further preclinical and clinical testing is warranted to determine whether highly malignant cells that are often resistant to conventional anticancer drugs may be sensitive to compounds like PEITC because of their high intrinsic ROS stress," says Dr. Huang....ActoGenix raises 11.5 million in series A stock financing
...ess plan and quickly build a valuable portfolio of preclinical and clinical-stage products based on its proprietary TopAct TM platform.' 'We have built a proprietary position around the TopAct technology and products and we are glad to be able to transfer this platform into the hands of an experienced manageme...Bacterial protein shows promise in treating intestinal parasites
...e the spectrum of activity of Cry5B as part of its preclinical development as a human therapeutic."...New drug blocks influenza, including bird flu virus
...nfection. The team hopes to move the research into preclinical phase as quickly as possible. Currently, there are a few effective antiviral medications on the market for influenza, but they are beginning to show signs that they are losing their effectiveness, and scientists and health professionals worry that ...Rush and UCSF found gene therapy appeared to reduce symptoms of Parkinson's by 40 percent
...d Raymond T. Bartus, PhD, who led the clinical and preclinical development of CERE-120 at Ceregene. "The planne...g of CERE-120 closely resembled its performance in preclinical studies both in terms of its overall safety as well as its possible efficacy," noted Raymond T. Bart...Successful one year gene therapy trial for Parkinson's disease announced by Neurologix
...will be able to successfully complete the required preclinical testing of its gene therapy for the treatment of epilepsy to enable it to file an Investigational New Drug Application with the FDA for permission to begin a Phase I safety trial or that, if filed, such permission will be granted. Other factors an...Tips from the journals of the American Society for Microbiology
...nsfer of antiretroviral immunity in the context of preclinical monoclonal antibody-based immunotherapy. Journal of Virology, 80.20: 10191-10200.)...Grape seed extract halts cell cycle, checking growth of colorectal tumors in mice
...th Sciences Center in Denver. "The value of this preclinical study is that it shows grape seed extract can atta...ive activity against skin cancer. Their subsequent preclinical work has shown that the extract also retards growth of prostate cancer cells. In this study, Agarwa...Gene variation affects pain sensitivity and risk of chronic pain
...s. The researchers originally identified GCH1 by preclinical screening for genes that undergo significant changes in expression after sciatic nerve injury. GCH1 is one of several genes that code for enzymes needed to produce a chemical called tetrahydrobiopterin (BH4). Previous studies have shown that BH4 is...Orexigen reports positive phase II results for Excalia Combination-Therapy to treat obesity
... an approved anticonvulsant medication. OREXIGEN's preclinical research suggests that combining these two central nervous system drugs acts on a complex of neurons in the hypothalamus, the area of the brain contributing to the regulation of appetite, energy output and maintaining body weight. The compound was te...U of MN Center for Drug Design awarded $2.5 million grant
...survivors of acute cyanide poisoning, and to begin preclinical studies that will lead to filing an application with the FDA for an investigational new drug (IND)....Turmeric prevents experimental rheumatoid arthritis, bone loss, University of Arizona study shows
...available for use. This work paves the way for the preclinical and clinical trials needed before turmeric supplements can be recommended for medicinal use in preventing or suppressing rheumatoid arthritis. This study also provides the first in vivo documentation of a mechanism of action how curcumin-containin...Predicting PET imaging's future: Diagnosing and treating diseases ASAP
... combined PET/computed tomography (CT) imaging and preclinical PET. Cherry foresees that additional advances w..."less noisy" images faster); very high resolution preclinical PET images (enabling researchers to make more intelligent choices in which drugs will be evaluated i...Muscle and bone from an ink-jet printer
...ineered regenerative therapies. In preparation for preclinical studies, the Pittsburgh researchers are following up this work by combining the versatile ink-jet system with advanced live cell imaging developed at Carnegie Mellons Robotics Institute and Molecular Biosensor and Imaging Center to further understand...Pittsburgh-based team engineers muscle, bone cell differentiation with aid of ink-jet printer
...m a single population of adult stem cells. The new preclinical advance in the field of regenerative medicine coul...ineered regenerative therapies. In preparation for preclinical studies, the Pittsburgh researchers are combining the versatile ink-jet system with advanced real-ti...Report calls for improved monoclonal antibodies against solid tumors
...ructs in clinical practice, clinical research, and preclinical research....Spelling out cancer on the nanoscale
... needle aspirates from hematopoetic tumor cells in preclinical transgenic mouse models. The nano-fluidic system physically separates the proteins in very small capillary tubes and then uses antibodies for protein detection. It was also tested on human lymphoma samples. In previous work, the Felsher group h...Researchers find stem-cell therapy effective in targeting metastatic cancer
...rostate and breast cancer, and are planning future preclinical trials using those tumors as well....Epigenetic drugs, promising for breast cancer treatment
...igenetic "principle" works and calls for increased preclinical and clinical efforts toward epigenetic cancer ther...arma" companies are not interested in pursuing the preclinical and clinical development of this type of drugs regardless of their potential antitumour efficacy sim......nded our technologies to the stage where they have preclinical candidates for treating hemophilia and infertility. Biogen Idec's acquisition is an excellent outcome because they have the expertise in manufacturing and development to bring these drugs to the clinic," said Neil Simister, a Brandeis biology profess...