Altering a protein makes mice less fearful
... gene might be associated with heritability of, or predisposition for, neuroticisim, phobias and other anxiety traits in humans. The UI team plans to determine the specific sites of action of ASIC1a in the brain, and focus on understanding the role of the ion channel in the amygdala. They also are interested in w...Gene expression pattern could lead to improved treatment of pediatric septic shock
...sis and treatment coincide with a person's genetic predisposition the study involves the largest gene expression analysis to date of blood samples from children with septic shock. It found new evidence linking adverse clinical outcomes with the decreased expression of genes that encode proteins involved in zinc re...Monell researchers find metabolic defect in liver that can lead to obesity
...hor Hong Ji used rats that differ in their genetic predisposition to gain weight and become obese when fed a high-fat diet. The closely-related strains weigh the same and eat the same amount of calories when fed a low-fat diet. However, when switched to a high-fat diet, the strain that is obesity-prone overeats...Global community listens to TAU genetic researcher at EU Conference on Hearing Loss
...gnostic tests for patients. Knowing ones genetic predisposition can certainly aid clinicians today and in the future for developing treatments and therapies to prevent further loss. One day a cure may be within reach, says Prof. Avraham, stressing the importance of international academic collaboration to achieve ...Gene variations directly link inflammation to an increased risk for lung cancer
...eavy smoking, for example, combines with a genetic predisposition to create a besieged environment within the lungs, said lead author Eric Engels, M.D., MPH, researcher at the Viral Epidemiology Branch of the NCIs Division of Cancer Epidemiology and Genetics. Essentially, sustained inflammation alters the microenvi...CU researchers solve mystery of how DNA strands separate
... associated with many human diseases, ranging from predisposition to cancer to premature aging," said co-author Smita Patel, a biochemistry professor at the Robert Wood Johnson Medical School in Piscataway, N.J. "Helicases are involved in practically all DNA and RNA metabolic processes." The researchers made their ...Tick-related disease thrives on cholesterol, study suggests
...ained normal in the mice which had the cholesterol predisposition but consumed the normal-cholesterol diet. Some people have mutations in the apoE gene, which controls apoE production. As a result, they cannot adequately maintain blood cholesterol. In humans, this mutation can cause blood cholesterol levels to si......in is hereditary, and thus that there is a genetic predisposition to become addicted to alcohol. Beta-endorphin is...low beta-endorphin levels and, therefore, a higher predisposition to become solitary drinkers and to develop alcohol abuse. ...Loss of cell's 'antenna' linked to cancer's development
... of organs (for example, heart on the right) and a predisposition to obesity, diabetes and high blood pressure. In each case, cells fail to appropriately detect growth-controlling signals and develop abnormally. Now, researchers are adding cancer to this list. Many cancers arise from defects in cellular signali...JCI table of contents: June 21, 2007
...prostate cancer risk in individuals with a genetic predisposition to cancer. So conclude researchers from Wake Fores...tate cancer risk in animals with a defined genetic predisposition to cancer, Yong Chen and colleagues studied Pten-knockout mice (which are predisposed to develop pro...Research team identifies new Alzheimer's gene
...cal diagnosis and help determine a persons genetic predisposition for developing Alzheimers disease. This discovery allows us to accelerate the development process for creating a new diagnostic test that is capable of detecting the presence of GAB2, and may ultimately help millions of individuals reach a more inf...Description of a gene implicated in the development of Fanconi anemia and predisposition to cancer
...and skeletal development, blood cell formation and predisposition to cancer. This discovery will aid in detecting the defective gene that causes Fanconi anaemia, which is fundamental in prenatal diagnosis and even pre-implantation diagnosis where the objective is to select an embryo that is compatible with a transp...Keeping the immune system from starting a 'food fight'
...ated the metabolic symptoms of mice with a genetic predisposition to obesity due to other factors. When food enters the system, STAMP2 normally keeps the immunity response "button" from getting pushed, Hotamisligil said. "We suggest that, over time, the accumulation of small cellular stresses due to daily chang...Salk scientist Ursula Bellugi elected to National Academy of Sciences
...e left hemisphere of the human brain has an innate predisposition for language, even for a language in which spatial and visual processing plays a central role. This predisposition of certain brain systems to process language, whether spoken or signed, is a striking demonstration ...A cherry on top: Tart cherries may alter heart/diabetes factors
...f an otherwise similar diet. All of the rats had a predisposition toward high cholesterol and pre-diabetes, but not obesity. All the measures on which the two groups of animals differed are linked to metabolic syndrome, a collection of risk factors linked to high rates of heart disease and Type 2 diabetes. Tens ...Researchers identify new genetic risk factors for type 2 diabetes
... diabetes, which is likely related to an increased predisposition to obesity. When the genomes of the Finnish participants were scanned for all 10 diabetes-associated genetic variants, researchers could identify individuals whose genetic profiles placed them at increased risk for type 2 diabetes including one su...Class of PCB's causes developmental abnormalities in rat pups
...s, in particular in infants who may have a genetic predisposition to developmental disorders based on their family history." Polychlorinated biphenyls (PCBs), used mostly as coolants and lubricants beginning in the 1930s, were banned in 1977. Early toxicology studies focused mostly on a subset of PCBs known as co......und to have a lifelong impact on their offspring's predisposition to obesity. Animals born of leptin-treated mothers remain lean even when fed a fat-laden diet, while those from untreated dams gained weight and developed diabetes. The difference boils down to energy expenditure. The offspring of leptin-treated mo...New diagnostic technologies offer non-invasive means
...ation patterns can potentially evaluate a patients predisposition to lung cancer. The pilot study of 33 individuals showed statistically apparent differences between never-smokers, former and current smokers, and those with lung cancer. According to Dr. Spivack, their findings could represent a considerable adva...Bronfman gift to Mount Sinai catalyzes genomics-based medicine
...ar analysis to better manage a patients disease or predisposition toward a disease. It represents a dramatic departure from "evidence-based medicine," which is based on population studies and has dominated medical principles for decades. While the evidence-based approach does allow doctors to modify treatment strat...