Old riverbed keeps chemicals from entering Ohio River
...VER -- A long-dry riverbed in northeastern Ohio is preventing a pool of chemical waste from infiltrating the Ohio River, geologists have found. The finding may call into question the need to clean up similar chemical waste sites. It also indicates a previously unknown interaction between an underground aquifer ...Researchers discover molecular timekeeper in bone development
...have widespread implications for understanding and preventing osteoporosis or other bone disorders, said Dr. Ols...HDAC4 controls the early timing of osteogenesis by preventing the final step, bone hardening from occurring. By specifically blocking a protein called Runx2, whi...By impounding iron, FHC foils cell suicide, fuels inflammation
... scientists show that a key step in the process of preventing cell suicide is the induction of ferritin heavy ch...F-, they found that FHC was the "pivotal mediator" preventing cell death. Next, they tracked down the mechanism FHC uses to block apoptosis. They found that by...Molecular technique shows promise in destroying drug resistance in bacteria
...s, such as by pumping antibiotics out of the cell, preventing them from entering the cell or demolishing them. A common way bacteria develop resistance is by laterally transferring plasmids -- pieces of extra-chromosomal DNA -- from one bacterium to another. These plasmids contain genetic codes for proteins t...A 'repulsive' protein guides blood vessel development
... drugs that mimic this function could be useful in preventing growth of the new blood vessels required by tumors." "One of the really interesting things about this paper is that it questions the idea that Sema3E's binding to neuropilin is required for vascular patterning," said Jessell. "This, together with th...Diamonds are a urologist's best friend
...'Up to now there has not been any effective way of preventing bacteria from entering the urinary tract via the catheter and thereby triggering urinary tract infection,' the Bonn researcher Dr. Norbert Laube explains. Several species of bacteria cause a steep increase in the urine pH value by their metabolism. T...New findings in innate immunity may lead to treatments for atherosclerosis
...herosclerosis. Compounds or strategies directed at preventing or enhancing IRAK1 modification and nuclear entry may hold great promise in treating atherosclerosis," concludes Dr. Li. Besides atherosclerosis, alterations in innate immunity can cause diabetes, cancer, and numerous other inflammatory disorders. F...Novel AT2R gene transfer prevents hypertension-related enlarged heart, cardiac fibrosis
...ned out to produce significant results in terms of preventing enlargement and hardening of the heart associated with hypertension. The study goes a long way in learning how hypertension develops as well how genes can be targeted and regulated within specific organs. Because the procedure didn't simultaneously ...Findings show how toxic proteins rob Alzheimer's patients of memory
... in patients who are treated early, in addition to preventing or delaying the disease. "Memory starts at synapses, so it was probable that Alzheimer's disease would be a synapse failure," said Klein. "Our work, which shows that ADDLs bind with great specificity to synapses, is the first demonstration of tha...Purdue research offers hope for canine, human spinal injuries
...y Purdue University researchers, offering hope for preventing human paralysis. Lab tests have shown that an injection of a liquid polymer known as polyethylene glycol (PEG), if administered within 72 hours of serious spinal injury, can prevent most dogs from suffering permanent spinal damage. Even when the spin...New drug sidesteps Gleevec resistance in human trials
...tions that impaired the flexibility of the kinase, preventing it from assuming the "off" position. To Sawyers and others, this raised the possibility that a second drug -- a "sloppier inhibitor" than Gleevec that didn't hold the target to such tight structural constraints -- might work against the mutations. In...Cigarette smoke a culprit in poor healing and increased scarring
...tion of these cells at the edge of the wound, thus preventing the formation of the healing tissue," she said. Martins-Green added that: "We're now trying to isolate the component or components in smoke that inhibit cell migration." ...NIDCR launches unique initiative on oral biofilm
...rstanding the oral biofilm but in more effectively preventing a subset of these bacteria from destroying our gums and decaying our teeth." Biofilms are sticky, mat-like microbial communities found throughout nature and many parts of the human body. They typically consist of hundreds of distinct organisms ...International HapMap consortium widens data access
...to develop better ways of diagnosing, treating and preventing human disease."...Discovery about Vitamin C explains its metabolic value
... body, which may help explain its possible role in preventing cancer and heart disease. The study, which was ju...ainst toxic compounds formed from oxidized lipids, preventing the genetic damage or inflammation they can cause." Some earlier studies done in another laboratory...Global bird populations face dramatic decline in coming decades, study predicts
...oted. Therefore, "investments in understanding and preventing declines in populations of birds and other organisms will pay off only while there is still time to act," the authors concluded. ...In wake of Lyme disease vaccine for people, mice may be next in line for shots
...r authors on the paper, "An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle," are J. Timothy Wootton at the University of Chicago; Durland Fish at Yale University School of Medicine; and Jonas Bunikis, Maria Gabriela Luna and Alan Barbour...JCI table of contents, December 15 2004
...ls may be another promising target for reducing or preventing bone metastasis. TITLE: Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer AUTHOR CONTACT: Olivier Peyruchaud INSERM Research Unit 403, Universit Claude Bernard Lyon 1, Lyon, France. Phone: ...Permanent resistance to antibiotics cannot be prevented
...fforts are primarily focussed on understanding and preventing the first stage, whereas the second stage is often omitted. Schoustra's research reveals that hindering the second stage (compensating for the negative effects of resistance) is extremely difficult, as bacteria and fungi can compensate for the negati...Antibiotic resistant bacterium uses Sonar-like strategy to 'see' enemies or prey
...he area, the first substance sticks to the second, preventing it from reporting back to the Enterococcus, and as a result, no toxin is made. According to Gilmore, "These bacteria are actively probing their environment for enemies or food. Based on whether or not they 'see' other cells, they make the toxin appro...