Researchers unmask malaria parasite's cloaking mechanism
...curs by packaging up the DNA into a tight form and preventing it from being expressed. That tight packaging involves SIR2," said Cowman. "The question then was how one of those genes is switched back on." The researchers knew that, in some organisms, gene regulation is dictated not only by DNA sequence and the ...New Zealand forest giant prevents landslides
...ully the positive effect of these forest giants on preventing landslides will contribute to their conservation....Gladstone investigators discover how resting T cells avoid HIV infection
...ould open the door to an entirely new strategy for preventing the spread of HIV infection in the body's cells, according to the senior author of the study, Gladstone Institute of Virology and Immunology Director Warner C. Greene, MD, PhD. The researchers, led by Ya-Lin Chiu, PhD, a postdoctoral fellow in the Gr...Of mice and men's (and women's) contraceptives
...n't know the complete mechanism yet, but it may be preventing the stabilization of specific messenger RNAs that need to be used at specific times as germ cells differentiate into mature sperm and eggs," explains Hecht. "An equally likely possibility is that the absence of MSY2 disrupts the timing of how specifi...JCI table of contents May 1, 2005
...seful for decreasing the damage of hypertrophy and preventing consequent heart failure. TITLE: Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure-load AUTHOR CONTACT: David A. Kass Johns Hopkins University, Baltimore, MD USA Phone: 410-955-7153...Vitamin E loss through smoking increases health risks
...irst role in intervening against free radicals and preventing membranes from becoming oxidized but in the proce...gets lost in the debate is the distinction between preventing a serious disease and being able to cure it," Traber said. Some recent studies, often done with sick...The promise of new medical uses for sodium nitrite for heart attack and organ damage
... of sodium nitrite had a strong protective effect preventing cell death in the hearts and livers of mice undergoing experimental heart attack and liver injury. In the heart study, nitrite reduced the size of the area of dead tissue known as an infarct by 67 percent compared to control animals given nitrate, a...Friendly bacteria in humans may protect against HIV
...i may provide a safe and cost-efficient method for preventing the spread of HIV, says Tao. "This method can protect infants against HIV in breast milk and women against HIV upon sexual contact unobtrusively and inconspicuously via fermented foods or feminine products," says Tao. "If the method can be success...Observational study suggests use of statins lowers risk of advanced prostate cancer
...r time, there is great translational potential for preventing invasive and metastatic prostate cancer," she says. The researchers believe most of the protective effect they observed comes from statins, rather than other types of cholesterol-lowering drugs, because by 2000 more than 90 percent of the men who rep...NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
...at while the results do not yet have relevance for preventing human colon cancer, they do illustrate the interplay between genes and common nutritional and medicinal agents in development of cancer in the intestines. The drug they tested, sulindac, was a highly effective chemoprevention agent, the researchers s...Combination of Lipitor and Celecoxib
... targeted different molecular pathways en route to preventing development of colon cancer, Reddy explained. The non-steroidal anti-inflammatory drug celecoxib targets the COX-2 inflammation pathway and has been shown both in experimental animal studies and in human trials to reduce the incidence and progression...Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma
...tumor cells are effectively silenced or shut down, preventing further growth. "This is the first study to show that systemic administration of siRNA can inhibit disseminated tumor growth," said Siwen Hu, a postdoctoral fellow at Children's Hospital of Los Angeles and the University of Southern California, and o...Turning viruses into allies against cancer
...eased during the initial viral attack, essentially preventing the spread of these cells to other parts of the body. "This aims to treat metastatic disease and reduce tumor recurrence," said Robert Coffin, Ph.D., chief scientific officer at Biovex Ltd. While this has not been demonstrated in patients, the appro...Molecule on immune cells linked to sexual transmission of HIV
... these dendritic cells. "Our findings suggest that preventing HIV from binding to the dendritic cells may block ...our findings point to a new therapeutic target for preventing HIV infection," said Dr. Peter Anton, UCLA professor of medicine. "Drugs could be developed to block...Brain-mapping technique aids understanding of sleep, wakefulness
...g sleep, send inhibitory signals to orexin neurons preventing them from releasing orexin. "Neurons producing orexin keep you awake, and they also stabilize wakefulness," Dr. Yanagisawa said. "In order to fall sleep, you somehow must inhibit these orexin neurons. It appears that sleep-active neurons in a speci...A healthy internal clock keeps weight off
...prising new angle for understanding and eventually preventing and treating obesity and related disorders in peop...prising new angle for understanding and eventually preventing and treating obesity and related disorders in people. "Timing is critical to keep the metabolic sym...Alzheimer's cognitive decline slowed
...rapy for a human neurological disease that acts by preventing cell death." In this first-ever gene therapy for Alzheimer's disease, UCSD physician-scientists took skin cells from eight patients diagnosed with early Alzheimer's disease. The tissue was modified in the lab to express nerve growth factor (NGF), a ...Wisconsin researchers identify sleep gene
...li says. "The cell membrane will remain activated, preventing long periods of deep, non-REM sleep." The researchers say that the fly research translates to humans even more than they thought it would. "Humans have the same kind of genes and potassium channels. And we know that slow waves must be generated by ch...Variation in immune response gene causes age-related macular degeneration when triggered
...ay provide powerful new therapies for treating and preventing AMD. "We now understand the genetic variation that is behind age-related macular degeneration and are beginning to target the trigger that sets the process in motion," said Rando Allikmets, Ph.D., Acquavella Associate Professor in the department of o...OHSU research shows vitamin C counteracts some negative impacts of smoking on unborn babies
...te a tremendous public awareness campaign aimed at preventing smoking during pregnancy. While this research find...suggest that vitamin C may be an important tool in preventing smoking-induced adverse outcomes." While the research demonstrates vitamin C's promise for counterac...