Gladstone researchers resolve key Huntington's disease mystery in Nature cover story
...ver we wish, and then determine which factors have prognostic value, whether they predict survival or neurodegeneration, and how strong the prediction is. This is a powerful new way to guide our investigation into the underlying mechanisms of neurodegeneration," he explains. In their study, the scientists intro...Gene expression profiling aids in ovarian cancer prognosis
...t this type of genetic test has proven useful as a prognostic tool for ovarian cancer, which accounts for approx...se. "The use of a powerful prognostic tool such as the OCPP may someday enable clinicians to identify those patients most appropriate for ...The Molecular Profiling Institute named US provider of genetic breast cancer test
... the United States for MammaPrint. MammaPrint is a prognostic test developed by Agendia that helps identify how ...ast cancer patients. Oncologists receive detailed prognostic information on women with primary invasive breast cancer aged 55 years or younger who are lymph node...Encouraging results from validation study of trial of personalized treatment in breast cancer
...SBIG consortium, which intends to use the 70-gene prognostic signature developed by the Netherlands Cancer Inst...id: "While the overall performance of the 70-gene prognostic signature in the external validation series was inferior to the original Amsterdam series, the resul...Children's Hospital Boston launches major genetic study of autism
...autistic spectrum disorders, better diagnostic and prognostic techniques, and potential medical treatments. More than 90 percent of autism cases are believed to have a genetic component, and multiple genes are believed to be involved. But although much research has been done and many candidate genes identified,...Mouse brain tumors mimic those in human genetic disorder
...o continue to hone in on more accurate diagnostic, prognostic and treatment approaches."...Agilent Technologies announces breakthrough for cancer researchers studying chromosomal changes
...ssion as well as developing possible therapies and prognostic and diagnostic tools. "Genomic alterations leading to changes in the number of gene copies present in cells are important events in the genesis and progression of cancer," said Michael Bittner of the Translational Genomics Research Institute. "Agilen...... epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma AUTHOR CONTACT: Richard C. Bates Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Phone: 617-667-2816; Fax: 617-975-5531; E-mail: rbates@caregroup.harvard.edu . This a...Scientists disprove two tenets of common leukemia
...ch is needed to establish its potential in guiding prognostic and treatment decisions. The study was small, examining 19 CLL patients. A larger trial is already underway to gain greater insights into the correlation and its potential clinical applications. The multicenter study is being led by Kanti Rai, MD, a...A more accurate screening test for prostate cancer?
... cancer to determine thymosin 15's usefulness as a prognostic predictor in combination with PSA testing. The Vascular Biology Program at Children's is also actively studying urinary markers for other cancers. In a small pilot study, Dr. Marsha Moses and postdoctoral fellow Dr. Roopali Roy recently found that ...Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
...effectively," said Dr. Chiorazzi. "Once these new prognostic markers are clinically available to doctors, and after large-scale trials testing early intervention are completed, the 'watchful waiting' practice may be abandoned in many cases," said Dr. Rai, who treats many CLL patients. "New and upcoming discove...Scientists identify molecule that regulates well-known tumor suppressor
...y. The authors go on to suggest that DJ-1 may be a prognostic marker for cancer patients and be useful as a target for development of future cancer therapeutics. Interestingly, DJ-1 may play a role in other disease states, as it has also been recently identified as a predictive diagnostic for early-onset, autos...Europe faces brain drain and declining patient care unless cancer research funding is doubled
... new and more effective non-drug interventions and prognostic markers depend on academic clinical trials for their development. "We need strong, independent clinical research in Europe that is funded by governmental and charitable organisations. Independent research of this kind can investigate the rarer and ha...Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis
...ver pathologies. This HEPATOCHIP can be used as a prognostic tool for NASH-predisposed patients, to make possible more finely tuned diagnosis of this disease and allow healthcare professionals to tailor treatment to individual patients' needs. This chip also assess the efficacy of non-alcoholic steatohepatitis...Readers of genome decipher signatures of cancer patient outcomes
...et included sub-clusters associated with important prognostic variables, predicting poor or better outcome," Spatz said. Such information may be used to suggest new treatment targets specific to this form of skin cancer. "In cutaneous melanomas, no active adjuvant therapy has been fully demonstrated so far," S...The Molecular Profiling Institute, Inc. launches MammaPrint for breast cancer patients
...ncer Center. Currently, one of the most important prognostic indicators for the cancer recurring is the size of the tumor. However, a significant number of tumors less than one centimeter in diameter are actually high risk. The 70 genes in a woman's tumor analyzed by MammaPrint predict the 10-year surviva...Study identifies possible marker for efficacy of gefitinib in lung cancer patients
...ce than drug efficacy," he writes. "Until reliable prognostic tools can be prospectively validated in clinical trials, clinicians will need to balance the desire to minimize false hope while maximizing the ability to offer clinically meaningful benefit to their patients."...JCI table of contents June 1, 2005
...urvivin in the pathogenesis of PAH, its value as a prognostic indicator, and its use as a target for new therapeutic strategies." TITLE: Gene therapy targeting survivin induces pulmonary vascular apoptosis and reverses established pulmonary arterial hypertension AUTHOR CONTACT: Evangelos D. Michelakis Universi...Researchers develop gene therapy to reverse pulmonary arterial hypertension
...urvivin in the pathogenesis of PAH, its value as a prognostic indicator, and its use as a target for new therapeutic strategies." Other authors include: Sean McMurtry, Pulmonary Hypertension Program; Stephen Archer, Canada Research Chair in Translational Cardiovascular Research; Dario Altieri, Department of Can...Genes linked to treatment resistance in children with leukemia
...ned the intensity of therapy. Patients with poorer prognostic factors 130 children were assigned to a high-ris...gh-risk arm, the VDR FokI genotype was found to be prognostic for CNS relapse, especially when combined with a VDR intron 8 genotype. In the low-risk group, the T...