Discovery offers promising lead in prostate cancer diagnosis
...e of the pioneers in developing new diagnostic and prognostic cellular and molecular markers for prostate cancer. Dr. Vessella is one of the primary leaders of a research effort at the University of Washington that is defining mechanisms of prostate cancer metastasis. This discovery was the result of a highly c...Scientists identify novel gene driving the growth and survival of melanoma cells
...e, we may be able to develop better diagnostic and prognostic tools as well as provide a target for highly specific therapies for metastatic melanoma patients who have this overcopied gene," explains Sellers, who also holds an appointment with the Broad Institute of Harvard and MIT and with Harvard Medical Scho...Biased reporting found in cancer prognostic studies
...ases may taint many published studies of so-called prognostic factors--biologic or genetic markers that may pred...chers have raced to discover and publish papers on prognostic factors for cancer and other diseases. For example, at least 116 published studies alone have focus...Other highlights in the August 17 JNCI
...ys, which may also affect survival. To examine the prognostic value of the method of breast cancer detection on ...ing the method of detection might add only limited prognostic value beyond that of well-established prognostic factors. Contacts: Article: Laura Sussman, Communi...JCI table of contents September 1, 2005
... MDS/MPD difficult to treat, and there are no good prognostic markers available. No single gene defect has been found for these diseases, and no animal model was available to study them. A common anomaly associated with these myeloid malignancies is a chromosomal deletion, suggesting the presence of one or more...Found! First gene associated with myeloproliferative diseases
... MDS/MPD difficult to treat, and there are no good prognostic markers available. No single gene defect has been found for these diseases, and no animal model was available to study them. A common anomaly associated with these myeloid malignancies is a chromosomal deletion, suggesting the presence of one or more...Microarray technology for tailoring breast cancer therapy
...ing, tumour stage and age - which are all accepted prognostic markers for breast cancer. The present lack of criteria to help tailor breast cancer treatment to individual patients indicates a need to develop new techniques for better prediction of how patients will respond to adjuvant treatments. The researcher...New brain tumor model developed
...e survey of INK4c status in order to determine its prognostic significance."...New treatment options for patients with prostate cancer
...to the prostate). Patients were divided into three prognostic groups of low, intermediate and high risk which included 18%, 27% and 55% of patients respectively. These groups were treated with either the higher dose of radiotherapy at 78Gy or the conventional dose at 68Gy. Some of the patients from the intermed......sts are able to distinguish between predictive and prognostic factors, they are better equipped to provide the c...0 or 1). After adjusting for the effects of known prognostic factors that were associated in this set with overall survival, namely PS (0 versus 1), prior platin...Deleted genes help predict outcome in a children's cancer
...of worse outcome for patients, regardless of other prognostic clues. For instance, unbalanced 11q LOH occurs alm...tatus of chromosome arms 1p and 11q to its list of prognostic markers in evaluating children with neuroblastoma. This information will be incorporated into future...Cancer scientists call for a large-scale human epigenome project
...nome and its application to developing diagnostic, prognostic and therapeutic tools will likely produce some of the earliest translational research benefits flowing from large-scale genome initiatives to the bedside," said Frank Rauscher, III, Ph.D., editor-in-chief of Cancer Research. "It is time to create a ...Little known DNA repair enzyme may be a tumor suppressor gene
... the development of some cancers and this may have prognostic and therapeutic implications. We are now investigating this hypothesis by selectively deleting the Rev3L gene in adult mouse cells to study how the loss of DNA polymerase zeta influences the development and progression of spontaneous cancers," explai...JCI table of contents: January 4, 2006
... of disease. In many cases, exactly how genes with prognostic significance figure into the disease process is no... in breast cancer patients, independently of other prognostic markers, and also how this protein triggers tumor development. They reveal that alpha-basiccrystalli...Breast cancercausing gene predicts shorter survival
... of disease. In many cases, exactly how genes with prognostic significance figure into the disease process is no... in breast cancer patients, independently of other prognostic markers, and also how this protein triggers tumor development. They reveal that alpha-basiccrystalli...Other highlights in the February 15 JNCI
...improve the accuracy of tumor grading and thus its prognostic value, the authors conclude. Contact: Christos Sotiriou, 32-2-541-34-28, christos.sotiriou@bordet.be Study Examines Gene Silencing in Prostate Cancer The observation that specific genes are silenced in both tumor tissue and in surrounding str...Proteomics symposium looks at pediatric applications
...ad to disease and are searching for diagnostic and prognostic markers that can be used in patients. (For more information, see http://www.childrenshospital.org/newsroom/Site1339/mainpageS1339P1sublevel188.html .) While similar to genomics, proteomics is far more complex: proteins have much more complicated str...Liver cancer linked to cellular repair pathway
...tages of liver cancer, as well as provide valuable prognostic information for patients," he said. Sicklick and colleagues also discovered a new Hedgehog pathway mutation in a patient with liver cancer that may lead to overactivation of Hedgehog and trigger abnormal cell growth, promoting cancer development. In ...Racial disparities in cancer not as simple as black and white
...ow economic standing contributes to similarly poor prognostic profiles for tumor grade and estrogen receptor sta...ioeconomic status, and they appear to have similar prognostic indicators with high-grade and ER-negative tumors, be they African-American or white". "Our results ...Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers
... proteins specific to cancer cells can be used for prognostic purposes, as can the newest type of biomarker, mcr... 79 percent, Nielsen said. Such a test could offer prognostic value to clinicians who are unsure whether to treat their newly diagnosed patients with surgery alon...