ESMO International Symposium on Sarcoma and GIST
...ranslate this knowledge into better diagnostic and prognostic procedures for patients, and to discuss potential new targets for treatment. The latest research suggests that sarcomas may be particularly vulnerable to the kind of 'magic bullet' targeted therapies that are currently in development for cancer. "T...JCI table of contents, May 18, 2006
...4 ONCOLOGY Gene expression signature acts as a prognostic indicator for liver cancer The identification of cancer-specific gene expression patterns or "signatures" is a fast growing area of cancer research. Aberrant activation of the Met signaling pathway is frequently associated with tumor growth and tumo...Researchers announce new predictor for lung cancer treatment and survival
...e believe this research confirms a significant new prognostic marker in lung cancer," says Dr. Dowlati, who is also assistant professor at Case Western Reserve University School of Medicine. "Previously, it has been a challenge to identify those patients that will respond best to treatment and what their outcom...Speeding discovery of the 'human cancer genome'
...he cancer's likelihood of spreading, although "any prognostic significance would require rigorous investigation and validation in appropriately designed prospective clinical trials." Taking a similar approach, Lowe's team identified two genes that can work together to encourage one form of liver cancer, calle...Chromosomal tests can determine brain tumor therapy, outcomes, Jefferson oncologists find
...e 1p and/or 19q deletion was highly predictive and prognostic of patient outcome, whether the patient received radiation and chemotherapy or radiation alone," Dr. Curran says. "Whether the patient had one or both deletions, the survival is much better." In the same journal issue, a European team showed nearl...Gene signature assesses breast cancer outcomes
...r, statistical analysis indicated that most of the prognostic information provided by traditional risk classifie... indicate that the gene signature adds independent prognostic information to that provided by a risk assessment based solely on clinico-pathologic factors." In a...REG1A and its receptor EXTL3 are prognostic markers for colorectal cancer recurrence
...indings suggest that the two genes are significant prognostic markers and may eventually help in making decisions about management of colorectal adenomas and tumors," said principal investigator Wolfgang Kemmner, Ph.D., who is Surgical Oncology Research Group Leader at the Max Delbrueck Center. Results were p...A tumor suppressor that promotes cancer cell growth?
.... The possibility of using H-REV107-1 as a novel prognostic indicator of tumor aggressiveness is appealing. Lung cancer is responsible for more deaths than any other cancer, with only 15% of patients reaching 5-year survival, and non-small cell lung cancer accounts for 75% of all lung cancer....Analysis of breast-cancer gene role offers promising target
...ogen activator system, is one of the breast-cancer prognostic factors that has the greatest level of evidence. "All the work has been on the protein and enzymatic activity and not amplification of the gene, which is a very reliable and easy-to-use diagnostic test called FISH," said Dr. Tripathy. "The other im...Genes offer researchers a 'crystal ball' to help them prevent, diagnose and treat cancer
...e has the potential to be used as a diagnostic and prognostic test, which could offer thousands of patients peace of mind and spare them from unnecessary surgery and therapy," said the study's lead author, Sven Perner, M.D.,, a postdoctoral fellow in the Department of Pathology at Harvard University's Brigham a...Researchers find two biomarkers with potential to predict breast cancer spread
...e of cancer is currently one of the most important prognostic factors predicting breast cancer survival, he said..."Protein peaks found in our study may be useful as prognostic biomarkers, but we must be cautious until the identities of these proteins are known and validated i...MGH Cancer Center researchers find new gene associated with Wilms tumor
.... "It has the potential of someday being a useful prognostic marker for Wilms tumor patients, and learning about its normal function could tell us more about both normal kidney development and tumorigenesis." Also called nephroblastoma, Wilms tumor develops in one out of 10,000 children and is usually treat...Tumor-free breast tissue can have precancerous changes
...re verified in more patients, they might lead to a prognostic test that could help doctors estimate a woman's risk of cancer recurring near the surgical site. Evidence began emerging 10 years ago that the healthy tissue adjacent to breast tumors may show precancerous changes, but the means to study the questi...Experimental Biology 2007: Today's Research, Tomorrow's Health, April 28-May 2
...likely to produce some of the earliest diagnostic, prognostic and therapeutic clinical tools). Ten distinguished scientists will give award lectures on topics ranging from the causes and consequences of aneuploidy (too many or too few chromosomes) to the relationship between PPAR (a transcription factor that ...Researchers identify ovarian cancer biomarkers
...ssed they were in the tumor vasculature, were also prognostic of a patient's survival. We suspect when these genes are highly expressed it may be a sign of a tumor that's able to grow blood vessels more efficiently, and therefore is more aggressive. This may help us down the road in treatment decisions," says l...Lack of a protein in lung tumors may increase risk of death
...r . "The absence of the protein may have important prognostic implications." Lung cancer is the leading cause of cancer illness and death worldwide. Every year, an estimated 1.2 million people are diagnosed with the malignancy, and 1.1 million others die from the disease. More than 85 percent of these cases ...Almac Diagnostics announces pioneering genetic research on colorectal pre-malignancies
...l was first demonstrated in colorectal cancer as a prognostic signature in stage II colorectal cancer to identify patients at high risk of relapse post surgery. Results from this study were presented at the American Society of Clinical Oncology (ASCO) annual meeting in 2006. Application of this technology pro...Study produces conflicting findings on the use of anti-anemia drug in cancer patients
...y the trial was not designed to focus on survival, prognostic factors were not balanced at baseline and no specific study procedures were undertaken to determine the exact cause of death for these patients, beyond investigator attribution. One confounding aspect of these study results was the different reacti...Breast cancer milieu -- Progression, tamoxifen sensitivity, and DNA reversion
...al involvement in breast cancer spread may provide prognostic implications if loss of its expression can be directly correlated with the transition from noninvasive breast cancer to recurrent and/or invasive breast cancer. Future studies will explore the exact mechanisms by which Fibulin-2 mediates its anti-inv...A close-up on pancreatic disease: How do we improve the odds?
...reliable, researchers are searching for additional prognostic factors as therapeutic targets, with the concept o...dent activation of the ErbB3 pathway seems to have prognostic significance among pancreatic cancer patients," said Juan Pablo Arnoletti, M.D., of the University o...