New findings may redirect strategies for treatment of prostate cancer
...eceptor (AR), a key determinant of prostate cancer progression and an attractive target for prostate cancer thera...mal male sexual development and contributes to the progression of prostate cancer. About one-third of prostate cancer patients develop metastatic disease and recei...JCI table of contents, November 15 2004
...the cleavage of pro-SF is an important step in the progression of tumor development and also suggests that drugs that inhibit this cleavage may lead to successful anti-cancer therapies. TITLE: An uncleavable form of proscatter factor suppresses tumor growth and dissemination in mice. AUTH...Inactive form of scatter factor protein found to suppress tumor growth and spread
...the cleavage of pro-SF is an important step in the progression of tumor development and also suggests that drugs that inhibit this cleavage may lead to successful anti-cancer therapies....Army-funded effort examines androgen's role in bone loss
...hought to curb potential risks for prostate cancer progression and other side effects that can result from androgen replacement. The Army grant, which began in November, comes on the heels of a study Wiren published in July in the journal Endocrinology. In it, she describes her research team's developme...University of South Florida designated Center of Excellence by Huntington's Disease Society
...al trials of potential new therapies that may slow progression of the disease." USF joins a select group of 21 HDSA Centers of Excellence across the country, including those at Johns Hopkins, Harvard/MGH, the University of Virginia, Emory and Baylor. "The Huntington's Disease Society of America is commit...Gene therapy shows promise in model of Parkinson's disease
...ally predisposed subjects and arrest the disease's progression once it has been diagnosed, according to Aebischer. "These observations could translate into the clinic either through a direct gene therapy approach or through the identification of small drugs which enhance the expression of the endogenous parkin."...International team finds gene variants that affect response to HIV infection
...n do mothers with alleles that do less to stop the progression of the disease. As a result, the frequency of the protective alleles would be expected to grow in the population. The researchers conducted much of their work at the new Doris Duke Medical Research Institute in Durban, which is the largest city of K...Study identifies key aspect of immune response against HIV
...g members of Partners HealthCare, and is a natural progression of the more than twenty-year commitment by the clinicians and scientists at those institutions to HIV and AIDS research and care. The Doris Duke Medical Research Institute at the University of KwaZulu-Natal (UKZN) opened in 2003 and was established t...Gene vaccine for Alzheimer's disease shows promising results
...ility of using a protein-based vaccine to slow the progression of the disease in its early stages. UT Southwester...ies have been clinically proven to slow or prevent progression of the disease. Amyloid protein deposits are present in the early phase of the disease a fact that ...JCI table of contents, December 15 2004
...hat platelet inhibition may slow the rate of tumor progression and metastasis. However to date, clinical trials o...latelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer AUTHOR CONTACT: Olivier Peyruchaud INSERM Research Un...Journal of Dental Research: New editor, new content, new look, new access
...and a research report on inhibition of root caries progression by an antibacterial adhesive. Commenting on these developments, Editor Smith said, "I am delighted that we have the opportunity to bring together the two premier journals from the dental field to provide a cutting-edge view of the oral and dental sc...Suspect protein found to play protective role in chronic lung disease
...w these pathways might be manipulated to treat the progression of asthma and COPD." Blackburn and UT Medical School at Houston Department of Biochemistry and Molecular Biology Chairman Rod Kellems, Ph.D., earlier developed a strain of mice lacking the protein that normally clears excess adenosine. These knocko...A key signaling molecule in osteoarthritis is identified
... signaling may eventually be used to slow down the progression of the disease, thus helping to relieve chronic pa...ular and cellular events during the initiation and progression of osteoarthritis is limited since current research efforts are mostly focused on either risk factor...JCI table of contents, 3 January 2005
...as a very accurate predictor of aggressive disease progression in MS. TITLE: Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS. AUTHOR CONTACT:Luisa Maria Villar Hospital Ramn y Cajal, Madrid, Spain. Phone: 34-913368795; Fax: 34-913368809; E-mail: l...Study examines relationship of vitamin A pathway to breast tumor progression
...he metabolism of vitamin A may contribute to tumor progression in breast cancer, according to a new study in the January 5 issue of the Journal of the National Cancer Institute . The study raises the possibility that this vitamin A pathway is a potential target for breast cancer prevention. Defects in vitamin A...Agilent Technologies announces breakthrough for cancer researchers studying chromosomal changes
...nding these changes is key to understanding cancer progression as well as developing possible therapies and progn...t in cells are important events in the genesis and progression of cancer," said Michael Bittner of the Translational Genomics Research Institute. "Agilent has now ...Scientists discover key genetic factor in determining HIV/AIDS risk
...sk of acquiring HIV and experiencing rapid disease progression is not uniform within populations," says Anthony S...e were more susceptible to HIV infection and rapid progression to AIDS. People with greater-than-average CCL3L1 gene copies, in contrast, were less prone to infect...Lynn Sage Comprehensive Breast Center plays role in newly approved breast cancer drug, ABRAXANE
...ubling the response rates and longer time to tumor progression when compared with Taxol," said principal clinical trial investigator William J. Gradishar, M.D., Associate Professor of Medicine, Division of Hematology and Medical Oncology and Co-Director, Lynn Sage Breast Cancer Program at Northwestern Memorial H...New family of genes could serve as a potential cancer marker
... understand the errors of genetic language and the progression of cancer, therefore giving researchers possible new solutions to reversing this dreadful disease."......, a cellular protein linked to the development and progression of cancer, according to research published in the January 15 issue of the journal Cancer Research . Tobacco smoke also promoted rapid cellular production of two proteins that initiate an epidermal growth factor receptor (EGFR) driven cascade leadin...