Newly discovered role for heart response enzyme may yield better heart failure therapy
...l stimuli as exercise or stress, as well as in the progressive loss of heart function that is heart failure, the researchers said. Their findings, they said, suggest new approaches to prevent or reverse heart failure, which affects two to three million people in the U.S. The team reports its findings in the Augu...Technique provides new look on response of diseased canine heart
... going to get DCM as they age," Oyama said. "It is progressive and invariably fatal." DCM typically occurs as dogs reach middle age, causing the heart to enlarge and lose its strength. Dobermans, Great Danes and boxers are predisposed to the disease, but it also commonly strikes the Scottish deerhound, Newfoundl...$7.3 million NIH grant establishes Wellstone Muscular Dystrophy Research Center at the UI
...are a diverse group of genetic diseases that cause progressive muscle wasting and weakness in affected individuals. The various types of muscular dystrophy differ in severity, age of onset, specific muscles affected and the rate at which symptoms progress. More than one million Americans have muscular dystrophy ...Global commitment of Max Planck researchers
...latently infected with the tubercle bacillus. With progressive HIV-1 co-infection, the risk of tuberculosis incre...on in endemic populations in Africa, the impact of progressive HIV-1 infection and its treatment and changes during vaccination with BCG and novel vaccine candidat...Gene changes linked to deficient immune suppression in MS
.... The MS patients had relapsing-remitting, primary progressive or secondary progressive MS and were not receiving any treatments for the disease at sampling time. The CD4+ and CD25+ T-regs...Expert system developed to enhance diagnostic accuracy of Alzheimer's disease with FDG PET scans
...ts, opening the door for earlier treatment of this progressive brain disorder. Details of their findings were provided at the Society of Nuclear Medicine's 52nd Annual Meeting in Toronto. "Positron emission tomography (PET) with FDG (fluorodeoxyglucose) in the hands of the experienced investigator is the most re......er of the skeletal system that is characterized by progressive osteosclerosis, particularly in the skull and mandible, but also in the clavicles, ribs, and diaphyses of long bones. Consequences of this increased bone mass usually include facial distortions and pinching of cranial nerves, and the increased nerve...JCI table of contents July 1, 2005
...1 diabetes - T cell link Autoimmune diabetes is a progressive disease that begins with mild symptoms and becomes more severe with destruction of the pancreatic islets. In a study appearing online on June 2 in advance of the print publication of the July 1 print issue of the Journal of Clinical Investigation, P...Heart failure wall stress drops 38% with moderate thyroid hormone therapy
...nts, it is possible that treatment may help arrest progressive chamber dilatation. Interestingly, there was no change in myocyte shape with the low-dose TH despite reversal of the myosin-isoform abnormality, which is a marker of fetal-gene program (FGP) reactivation, the paper notes. "This suggests that signa...Variation in immune response gene causes age-related macular degeneration when triggered
...e age of seventy-five. The disease is marked by a progressive loss of central vision due to degeneration of the macula--a region of the retina and the area responsible for fine, central vision. The study was conducted in two parts biology and genetics. Dr. Allikmets, senior author on the paper, led the geneti...Alzheimer's cognitive decline slowed
...ss is a cardinal feature of Alzheimer's disease, a progressive brain disorder affecting memory, learning, attention and other cognitive processes. "If validated in further clinical trials, this would represent a substantially more effective therapy than current treatments for Alzheimer's disease," said Mark Tus...Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis
...posed subjects. Non alcoholic steatohepatitis is a progressive disease of the liver of unknown etiology, characterized histologically by fatty acid accumulation, hepatocyte damage and inflammation resembling alcoholic hepatitis. NASH is a critical stage in the process that spans from hepatic steatosis to cirrhos...VCU research shows Viagra prevents anti-cancer drug induced heart damage
...f cancer, its use is associated with a delayed and progressive cardiomyopathy, often presenting several years after treatment cessation. "Viagra is able to protect the heart from damage that would otherwise disrupt normal cellular functioning," Kukreja said. Kukreja and his colleagues began studying sildenafil...U. Iowa researchers improve Huntington's disease symptoms in mice
...ting, inherited, neurodegenerative disease that is progressive and always fatal. The disease-causing gene produces a protein that is toxic to certain brain cells, and the subsequent neuronal damage leads to the movement disorders, psychiatric disturbances and cognitive decline that characterize this disease. "Ma...NASH clinical research network launches new trial for treatment of liver disease
... show no outward signs of a liver disease, NASH is progressive and can lead to cirrhosis and end-stage liver disease, which may require liver transplantation. The only way to distinguish NASH from other forms of fatty liver disease is with a liver biopsy. "NASH has become a serious public health problem, because...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
...enetic diseases, all of which are characterized by progressive weakness and degeneration of the skeletal muscles which control movement. The Muscular Dystrophy Association and Genzyme Corporation supported the research. Several forms of Pompe disease affect more than 5,000 people in the U.S. If symptoms appear d......rds. "That they become infertile is related to the progressive loss of maturing germ cells in the testis." The animals lack sperm because of defects inherent to the cells that serve as progenitors of sperm - cells that are usually found in the adult testis. "This is the first paper to show that in the period of ...Childhood deficits in the cerebellum may be linked to adult alcoholism
...function. Long-term heavy drinking can also cause progressive degeneration of the cerebellum for some alcoholics. Defects in the cerebellum itself, however, have never been considered as a potential cause of alcohol dependence. In a first-of-its-kind study, researchers in the March issue of Alcoholism: Clini...Silence the gene, save the cell: RNA interference as promising therapy for ALS
... President and a co-author of the study. ALS is a progressive neurological disease that attacks the motor neuron... as a potential therapy, particularly in incurable progressive neurological diseases such as ALS. "I would not be surprised to see, in the next ten years, this tec...Gene variant increases risk of age-related macular degeneration
...e-related macular degeneration (AMD). The chronic, progressive disease -- which affects as many as 15 million peo...ways for drug development," she added. AMD causes progressive impairment of central vision, and is the most common cause of legal blindness in Americans over the ...