New analyses reinforce efficacy of Remicade in treatment of severe psoriasis
... treated with REMICADE experienced significant and progressive improvements in psoriasis affecting the nails. Na...n the patients' overall burden of disease." The progressive improvements in nail psoriasis observed in patients receiving REMICADE 5 mg/kg were consistent with ...Biogen Idec acquires Brandeis spin-out
...patients two or three times a week greatly reduces progressive joint deterioration commonly seen in hemophilia patients as a result of the bleeding....Nicotine: The link between cigarette smoking and kidney disease progression?
...rate that cigarette smoking increases the risk for progressive chronic kidney disease, but the role of smoking in primary renal diseases is less known. The results of this research, coupled with earlier findings, reveal previously unrecognized mechanisms showing nicotine a component of cigarette smoke as an a...NIH gives PITT $13 million grant for chronic obstructive pulmonary disease research
...gger immune response leading to BALT formation and progressive airway damage. Concurrent studies will look at how genetic factors and other molecular mediators affect lung tissue injury by focusing on damage to cellular repair mechanisms related to the inflammatory process. Project leaders are Drs. Duncan and Ho...Male contraception -- UVa discovery stirring interest among basic scientists and drug developers
... was blocked, the sperm barely quivered, showed no progressive motion and were infertile." By contrast, prior experiments found that when the oxidative processes in the sperm's mitochondria are blocked, sperm continue to swim and fertilize eggs. "Because they will aim at specific proteins like SFEC and targ...Gene linked to aggressive 'wet' age-related macular degeneration
...ve cells in the retina to break down, resulting in progressive loss of central vision. Of the two forms of AMD, the "dry" is more common than the "wet" form. Wet macular degeneration can rapidly lead to blindness, while the dry AMD progresses more slowly. Last year, Josephine Hoh, associate professor in the De...Gene therapy for hereditary lung disease advances
...ome patients lead to emphysema and cirrhosis, both progressive diseases that can be fatal. Alpha-1 patients with symptoms of emphysema can be treated through weekly intravenous injections of alpha-1 protein derived from human plasma. The injections must continue throughout a patient's life, according to the Am...Kentucky first state to match federal SBIR-STTR Phase 1 and Phase 2 grants
...d Phase 2 grants, respectively. "This unique and progressive program is tailored to the particular needs of Kentucky's high-tech and knowledge-based businesses," said Economic Development Secretary Gene Strong. "It will significantly enhance Kentucky's economic competitiveness and is already helping attract en...Philippines president enacts new national conservation policy
...nd in the future," Seligmann said. "More and more, progressive leaders are recognizing that a healthy environment is the foundation for stable, productive societies that can develop in a sustainable manner." The 2004 study by Kent Carpenter, and Victor Springer identified the central Philippines as the "center ...News tips from the Journal of Neuroscience
...m of amyotrophic lateral sclerosis, resulting in a progressive loss of motor neurons. This week, Lai et al., using a combination of molecular and electrophysiological approaches, found that loss of the ALS2 gene product alsin in ALS2 -/- mice causes defects in AMPA receptor trafficking. When Lai et al. looked f...Common cause of heart disease, diabetes may be treatable with malaria drug
... risk of tumors, immunological problems and severe progressive deterioration of a part of their brain that controls muscle function and coordination. In the present study, the Washington University/St. Jude team demonstrated that the ATM enzyme is important for many of the beneficial effects of insulin and tha...Accelerating loss of ocean species threatens human well-being
...ve observed at smaller scales, and they prove that progressive biodiversity loss not only impairs the ability of oceans to feed a growing human population, but also sabotages the stability of marine environments and their ability to recover from stresses. While the data show that ocean ecosystems still hold gr...Researchers identify molecule that causes destructive lung inflammation in cystic fibrosis patients
...lt-, water- and mucus-making cells. It is chronic, progressive and life-shortening. About 30,000 people in the United States have CF and about 1,000 babies are born with it each year. The life expectancy of a child born with CF is 36.5 years. The Antonio J. and Janet Palumbo CF Center at Children's follows more ...Accelerating loss of ocean species threatens human well-being
...ve observed at smaller scales, and they prove that progressive biodiversity loss not only impairs the ability of oceans to feed a growing human population, but also sabotages the stability of marine environments and their ability to recover from stresses. Every species matters. "For generations, people have ad...Salt intake is strongly associated with obesity
...ng intakes of sodium (salt) obligatorily produce a progressive increase in thirst. The progressive increase in the average intake of salt explains the observed concomitant increase in the intake of b...Scientists develop new treatments for Alzheimer's disease
...s' disrupt the normal function of cells leading to progressive memory loss which is characteristic of Alzheimer's disease. The clumps are formed from a small protein fragment called Amyloid-beta (A-beta) peptide released from its 'parent' protein - amyloid precursor protein (APP). This process requires the ac...Insights into activity-dependent neuronal growth through RSRF-supported research
...factors. On the one hand, mutant neurons exhibit a progressive decline in BDNF content after birth; the timing of this decline varies among different brain regions. On the other hand, mutant neurons release a greater percentage of their BDNF content. Thus, early in development, MeCP2 deficient neurons release mo...News tips from the Journal of Neuroscience
...serine proteases in axon degeneration in mice with progressive motor neuronopathy ( pmn/pmn). This so-called "dying back" motor neuron disease starts in axon terminals, followed by degeneration of cell bodies, and is paralleled by increases in PA levels in sciatic nerves. The pmn/pmn animals show weakness and mu...Rescuing injured hearts by enhancing regeneration
... after the heart attack, since many people sustain progressive damage to their hearts from repeated minor infarctions. In this study, rats were treated soon after injury. Second is the need to develop a safe delivery method. Because FGF1 stimulates angiogenesis, it has the potential for serious side effects if...Researchers discover misfolded protein clumps common to dementia, Lou Gehrig's disease
...ause of dementia in people under age 65. ALS is a progressive disease of brain and spinal cord motor neurons that control movement. Over time, walking, eating, speaking and breathing become more difficult in this fatal disease. Some people with ALS also have FTD, and some with FTD also develop ALS, suggesting t...