Mitochondrial biology gets a new chaperone
...thors identify a null mutation in a patient with a progressive encephalopathy, and show that the defect can be fu...r mitochondrial complex I assembly is mutated in a progressive encephalopathy AUTHOR CONTACT: Eric Shoubridge Montreal Neurological Institute, Montreal, Canada ...Climate change more rapid than ever
...ignificant result of these future scenarios is the progressive raising of mean global temperatures and the movement of climate zones in connection with that," says Dr. Erich Roeckner, the project leader of the model calculations in Hamburg. "Almost everywhere on earth, the forestry industry will have to husband ...First report of cancer drug Gleevec as new target therapy for pulmonary hypertension
...ib) in two well established experimental models of progressive pulmonary arterial hypertension. His group found, that the treatment resulted in virtually complete reversal of lung vascular remodeling, pulmonary hypertension and right heart hypertrophy. The common findings suggest, that Gleevec's uses might expan...Study points to molecular origin of neurodegenerative disorders, including Huntington's disease
...ween ages 15 and 30 years) and is characterized by progressive and widespread damage to brain function, leading to loss of coordination, seizures, paranoid delusions, dementia and death within 15 to 20 years. Scientists are uncertain if protein deposition causes nerve cells to deteriorate and die. However, studi...Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models
...slie Crews, both at UCSD. Alzheimer's disease is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly in the United States, affecting 4.5-5 million adults - 10 times more than those affected by Parkinson's disease. Starting with mild memory problems and ending with sev...Molecular defect found that may cause heart failure
...hat may be a fundamental cause of heart failure, a progressive weakening of the heart that leaves the organ unable to pump blood through the body. The findings, by researchers at the Ohio State University Dorothy M. Davis Heart and Lung Research Institute, show that specialized proteins called ryanodine recepto...Old drug shows new promise for Huntington's Disease
...e of the brain that causes changes in personality, progressive loss of memory and cognitive ability, and a characteristic uncontrolled jerking motion known as Huntington's chorea. There is no known cure or effective treatment. A person who carries the mutant Huntington's gene may pass it on unknowingly because t...Can ancient rocks yield clues about catastrophes like Hurricane Katrina?
...dern ocean into an anoxic mode are unknown but the progressive emission of greenhouse gases to the modern atmosphere is gradually shifting Earth towards a greenhouse mode with an accelerated hydrological cycle.' 'At present it is hardly possible to estimate where we are on the long-term climate trend but once th...Animal model of Parkinson's disease reveals striking sensitivity to common environmental toxins
...odegenerative disorders, it is associated with the progressive and selective loss of a specific population of neurons in the brain, the dopaminergic neurons of the substantia nigra pars compacta . Exposure to several common environmental toxins, thought to injure neurons through oxidative damage, has been shown ...Cancer drug target Chk1 may also be source of drug resistance
...ncer cells to escape drug-induced death and resume progressive tumor growth. The study suggests the Chk1 protein is critical for ensuring the repair of mutations and other errors in DNA replication before they can alter the function of a cell. If not repaired, these errors can kill the cell when it attempts to......) were hair loss, reduced fitness and body weight, progressive curvature of the spine, and a shortened lifespan. "Aging and cancer are two sides of the same coin. In one case, cells stop dividing and in the other, they can't stop dividing. We suspect that having the right amount of the p63 protein in the right ...No small feat: First ever gene therapy success for muscular dystrophy achieved
...20 inherited muscular dystrophies characterized by progressive and severe muscle wasting and weakness first noticed soon after birth. No effective treatments exist and children usually die quite young. Despite gene therapy being among the most vigorously studied approaches for muscular dystrophy, it has been bes...Tiny roundworm's telomeres help scientists to tease apart different types of aging
...licative or cellular aging. Some have likened this progressive erosion of telomeres to a genetic biological clock that winds down over time, leading to a gradual decline in our mental and physical prowess. Yet, C. elegans, a tiny creature, which spends the better part of its adult life without a single dividing ...History of Earth Sciences Society joins AGI
...on's 43rd member society. "Knowing the history and progressive nature of our field is an important component of understanding the development of theories and systems in earth sciences. We look forward to their participation in the federation," says AGI Executive Director, Marcus Milling. HESS, formed in 1982, is...Research casts doubt on circulating stem cells
...n important muscle protein. Those affected develop progressive muscle wasting. They only have a life expectancy of 15 to 20 years. "In mice with DMD we have replaced the bone marrow with healthy marrow marked by a fluorescent gene," explains Bonn physiologist Professor Dr. Anton Wernig. The hope of the medical ...Amphetamine-related drugs ameliorate symptoms of Parkinson's
...e activity a challenge. The symptoms result from a progressive deterioration of neurons, found in the midbrain, that produce dopamine. With no cure on the horizon, the most common treatment involves administration of the dopamine precursor, L-DOPA, usually in pill form. Though symptoms subside at first, this tr...Motoring proteins and genetic disease
...), affecting about one in 100,000 births, includes progressive blindness, extra or fused fingers and toes, kidney disease and learning difficulties, among other problems. Products of genes linked to the syndrome coordinate mobile, cargo-carrying motor proteins within the cilia, tiny hairs found on the surface of...Bacteria feed on smelly breath (and feet)
...ths of healthy volunteers and those suffering from progressive gum disease (periodontitis), a condition which is often associated with smelly breath. However, no assessment was made of the levels of methylotrophic bacteria present, low levels of which may be associated with bad breath. In a previous paper, Dr Wo...Impaired clearance of amyloid-beta causes vascular damage in Alzheimer's disease
...over. Alzheimer's disease, the most common form of progressive dementia, affects an estimated 4.5 million Americans according to the Alzheimer's Association. Amyloid-β (Aβ) deposition is a hallmark of Alzheimer's disease and other cerebral amyloid angiopathies. However, exactly how Aβ accumulates...Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy
...l. The mutation in the dystrophin gene causes the progressive deterioration of skeletal muscles seen in people w...a new therapeutic agent for preventing or limiting progressive damage to the hearts of patients with muscular dystrophy," Metzger says....