Gene linked to enlargement of the factory where proteins are processed
...o they can be secreted from the cell. The UPR also prompts the cell to make molecules called chaperones, which do the actual task of protein folding. XBP1 triggers the cell to make phosphatidylcholine, the major building block of the rows of membranes that make up much of the factory, which is called the end...Genetically modified natural killer immune cells attack, kill leukemia cells
...y modified to brandish a powerful "on-switch" that prompts them to aggressively attack and kill leukemic cells. This finding, from researchers at St. Jude Children's Research Hospital, suggests a way to improve the outcome of children who receive treatment for acute lymphoblastic leukemia (ALL) or other bloo...14 highlighted physiology papers from IUPS 2005: From 'genomics to functions'
...nment. Human benefits could come from learning the prompts to exercise and mechanisms of system improvement. "VO2max and muscle O2 transport in rats continue to diverge with further selective breeding for endurance running." Richard A. Howlett, University of California, San Diego. 936.2. "Cardiovascular d...Researchers test new therapy for advanced melanoma
...h Florida are testing a promising new therapy that prompts the immune system to aid in the fight against melanoma tumors. "This is a milestone clinical trial because it is the first time that electroporation is being used to deliver plasmid DNA in a gene therapy study in humans," said Richard Heller, PhD, U......nd other internal tissues. At the same time, Twist prompts the Cdc25 gene to step up activity, as well as activating the production of HOW. HOW then takes direct action against Cdc25 RNA by breaking it apart, leading to the arrest of cell division during mesoderm invagination. When Volk and her team studie...Genome of a social amoeba sequenced for the first time
...he way to novel therapeutic approaches. Starvation prompts the solitary cells to aggregate and develop as a multicellular organism consisting of up to 100,000 cells, where individual members of the community sacrifice themselves to ensure the survival of others. In terms of its developmental lineage, the soc...Difference in talking louder, talking over noise depends on verbal cues, internal targets
... the "easiest" in terms of producing SPL. 'Noise' prompts higher SPL, but also effort for clarity by slowing down Most interesting of all the findings was that in the "noise scenario," all speakers slowed their speech markedly. Why? "Speakers may have perceived the need to use a slower speech rate in the ...Leprosy microbes lead scientists to immune discovery
...ave discovered how the body's early warning system prompts a rapid immune response by two separate armies of defensive cells. The finding helps explain why, when threatened by microbes like the leprosy bug, this initial defense sometimes succeeds in limiting the damage, but in other cases yields to a dangero...Environmental chemical cocktail may sabotage sperm
...er external compounds have acted on the cell, that prompts an appropriate response. In the case of sperm, increased cAMP production appeared to stimulate premature sperm capacitation. "The sperm were still alive and their ability to move was unaffected, but the spontaneous acrosome reaction meant that they w...MIT develops 'Anklebot' for stroke patients
...e attached to the arm of the robot. A video screen prompts the person to perform an arm exercise such as connecting the dots or drawing the hands of a clock. If movement does not occur, MIT-Manus moves the person's arm. If the person starts to move on his own, the robot provides adjustable levels of guidance...Why do aneurysms form? New studies suggest leading role for white blood cells
... question of how those enzymes get there, and what prompts them to arrive, has been unanswered. "Neutrophils are known to carry some of these enzymes, called matrix metalloproteinases and chemokines, which help them attack invaders," says Upchurch. "We wanted to see what the role of neutrophils was in the e...Elderly mice yield clues to the process of growing old
...ve found that an accumulation of genetic mutations prompts a cascade of programmed cell death that seems to u...mitochondria slow metabolism. In turn, that change prompts cells to produce fewer of the reactive free radical molecules. The symptoms of aging become pronoun...Scientists discover more about how cancer cells form and grow
...haps HGF gets jagged1 levels to increase, and that prompts a connection between the tumor and endothelial cells. Sorting out this connection, Wang considered involvement of notch, another protein on the endothelial cells. Notch is known to help in the formation of blood cells, and jagged1 binds to notch. Wan...The link between fasting and acute attacks of porphyria
...ion" signal that fasting sends throughout the body prompts PGC-1a to jump-start the process of creating glucose from scratch in the liver. However, PGC-1a also regulates the activity of an enzyme called ALAS-1, the first key enzyme in the heme production pathway. The higher levels of PGC-1a produce higher le...Study sheds light on signaling mechanism in stem cells, cancer
...n to its receptor on the target cell's surface, it prompts the cell to move Smoothened, located in vesicles a... positioning of Smoothened on the cilium, in turn, prompts downstream signaling of Hedgehog signals into the nucleus, where the instructions are issued. Just h...First analysis of FDA's mifepristone adverse event reports
...e information in many of the adverse event reports prompts Gary and Harrison to speculate on whether the FDA's Adverse Event Reporting System adequately identifies risks and protects public health. At least 5 women in the US and Canada are known to have died from septic shock after taking mifepristone. In 20...Losing sleep undoes the rejuvenating effects new learning has on the brain
...he task, the researchers noted. Sleep restriction prompts use of a secondary strategy On the other hand, the sleep-restricted rats that were required to locate the platform using visual and odor cues did better on the task than their rested counterparts. This was an unexpected finding. Hairston et al. beli...Molecule does more than slice and dice RNA
... causes genes to be turned off and which, in turn, prompts a host of key developmental events. With the structure of Dicer solved, Doudna's group showed that the enzyme is more than a molecular cleaver -- it also carefully measures and snips strands of RNA into precise increments. When Dicer cleaves large st...'Virus chip' detects new virus in prostate tumors
...ntification of this virus in human prostate tissue prompts many more questions than it answers, they emphasize. "A hit on the array is not the end of the project; it's the beginning," Ganem says. "Pathogen discovery is really hard work." The team intends to carry out epidemiology studies to determine how wid...Barbara Turnbull Award honours leading spinal cord researcher
...as neurons in the human spinal cord-something that prompts scientists to refer to the spinal cord as "the worm within us". "Knowing what Barbara Turnbull has done in her life and what she has done for spinal cord research, I am particularly amazed and honoured by this award," says Dr. Culotti. "She's a speci...