Commandeering cellular machinery: recognition mechanism to detect small molecules
... But more importantly, the new receptors serve as proof of principle for the protein engineering technique used to produce them. Doyle envisions using that technique to produce other nuclear receptors that could be the basis for sensing arrays in which a variety of receptors, each sensitive to a differen...Arctic mystery no longer: Dinosaurs walked Canada's great north
... (located in Montreal, Canada), has found physical proof that Canada's Arctic regions once had a Jurassic era. Scientists have suspected that dinosaurs lived in Canada's great north eons ago, yet it remained an unproven theory, since no bones had ever been uncovered. Not anymore. Larsson has discovered tyr...An old adage about apples finds scientific backing
...e properties of these polyphenols, they also offer proof of their potential to prevent colon cancer," said Francis Raul, Ph.D., the study's lead investigator and Research Director of the French National Institute for Health and Medical Research (INSERM) in Strasbourg, France. Medical practitioners a...New DNA repair enzyme makes mistakes to save lives of cells
...w survived. Those that did were severely impaired, proof of an unstable genome. "We know that the ATM gene is intimately related to cancer lymphomas, so based on this group's findings, it seems that an impairment or lack of POL-Q function may be tied to a cancer-prone pathway. This is certainly worth furth...Pesticides may promote Parkinson's disease and exercise may offer protection
...vironmental toxins. "We think this is an important proof of the concept that what we eat, drink, breathe, or are otherwise exposed to can predispose us to Parkinson's disease," says Greenamyre. One of the most promising new drugs for the treatment of Parkinson's disease is rotigotine, which acts as a dopa...Sperm enzyme is essential for male fertility, study shows
...oduction along the sperm tail. This paper provides proof of principle that GAPDS may be an effective target for a contraceptive agent." Co-authors with O'Brien are Dr. Kiyoshi Miki, research assistant professor in cell and developmental biology; Dr. Weidong Qu, postdoctoral researcher at UNC and associate ...Army-funded effort examines androgen's role in bone loss
...e receptors everywhere, but these mice demonstrate proof of concept that the androgen receptor in bone is responsible for sexually dimorphic skeletons. In other words, that male bones are wider than female," she said. "This is an important model to look at the influence of gender on bone development and sk...University of Texas at Austin researchers identify drug-tolerance mechanism in flies
...e more drug resistant than normal, providing added proof of the gene's importance for tolerance. Because the human slo gene is almost identical to the one in fruit flies, Atkinson said, "If we could describe the series of steps involved in changing slo gene expression, then all the components involved...UCSD biologists identify gene in corn plants that may have paved way for development of maize
...ers is a smoking gun. But we don't have the direct proof yet. We need to do some follow up studies to see if this gene was really involved." ...Vaccination with anthrax capsule protects against experimental infection in animals
...otection. This study provides the first definitive proof of that concept. The research team vaccinated several groups of mice. One month after the second dose, the mice were challenged with lethal doses of spores from a strain of anthrax producing only the capsule. In the group that had received the capsul...Key to understanding how blood and blood vessel cells develop discovered
... appeared this month in Nature gives the strongest proof yet for this theory. Gordon Keller, PhD, Professor of Gene Therapy and Molecular Medicine and colleagues identified the shared precursor cell, called the hemangioblast in early mouse embryos. While the existence of this cell was first proposed over o...Combined stem cell-gene therapy approach seen as potential treatment for cystic fibrosis
...ucus and air-borne irritants. "Our results provide proof of principle that a cell-based therapy using marrow stromal stem cells is both a feasible and promising clinical approach. We plan to further investigate its potential and are hopeful that we can perform a small clinical trial within the next two to ...Story tips from the Department of Energy's Oak Ridge National Laboratory, January 2005
...ergei Kalinin says the butterfly images are just a proof on concept - the new strides in advanced scanning probe microscopies will eventually provide a "wonderful tool" for understanding, as well as viewing, properties and functionality of living biosystem's on length scales from macroscopic to molecular. ...Research could lead to new treatments for blindness
...e a functional photoreceptor." "It is an important proof of principle that melanopsin can make non-light sensitive cells receptive to light and, although not a cure, could have applications in treating some forms of blindness." Researchers also believe that defects in melanopsin action could be responsible...Researchers discover way to make cells in the eye sensitive to light
...ate a functional photoreceptor. It is an important proof of principle that melanopsin can make non-light sensitive cells receptive to light, and although not a cure, could have applications in treating some forms of blindness." Dr Rob Lucas, from the University of Manchester, and one of the paper's author...UCLA researchers detail the evolution of quantum dot imaging in the journal Science
...new advances are highlighted in Science, including proof of principle in animal models that qdots can be used to image processes at the cellular level, work done at the UCLA Crump Institute for Molecular Imaging. In the study, qdots were labeled with a positron-emitting isotope and injected into mice. Usin...Wisconsin scientists find portal to show animals evolve
...cess and survival. It is, says Carroll, convincing proof that evolution occurs as accidental mutations create features - a spot here or a stripe there - that confer advantages in attracting mates, hiding from or confusing predators, or gaining access to food. The mutations are preserved, according to the...Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
... living rodent. Their findings, which represent a proof of principle for the use of emissive polymersomes to target and visualize tumors, appear in the Feb. 7 online early edition of the Proceedings of the National Academy of Science. "We have shown that the dispersion of thousands of brightly emissive mu...Study finds direct association between cardiovascular disease and periodontal bacteria
...ans. But the researchers say the findings are not proof that the bacteria cause cardiovascular disease, directly or indirectly. "What was interesting to us was the specificity of the association," said Mose Desvarieux, M. D., Ph. D., the study's lead author and an infectious disease epidemiologist at Colu......m deadly outbreaks." The paper provides definitive proof for the assumption that Ebola moves from wildlife populations to humans through the consumption or handling of carcasses or bushmeat. Specifically, the researchers found that Ebola infections in wild animals such as gorillas, chimpanzees, and occasi...