Study identifies molecular complex vital to creation of miRNAs
...ists have noted, too, that miRNAs are critical for proper neuronal development. Might miRNA activity, then, provide a new window on schizophrenia, at least in DiGeorge syndrome patients, but perhaps also more globally? "It would certainly be possible to look in schizophrenic populations for mutations in the...A 'repulsive' protein guides blood vessel development
..., channeling the blood vessels to grow along their proper course. Meanwhile, Yoshida discovered that unlike other members of the same protein family, Sema3E binds selectively to plexin-D1 a strong hint that the two signals work together to control vascular patterning. Yoshida also found that Sema3E can bi...UCI researchers use human embryonic stem cells to aid spinal cord injury repair
...fibers. This tissue is critical for maintenance of proper nerve signaling in the central nervous system, and, when it is stripped away through injury or disease, sensory and motor deficiencies and, in some cases, paralysis result. In this study, neurologist Hans Keirstead and colleagues at UCI and the Geron...Studies suggest promising new directions for gallstone treatment
...etermine whether such a drug could reestablish the proper equilibrium of the bile components." To do this, the researchers gave CGD-susceptible mice, which were fed a lithogenic diet, a synthetic compound, code-named GW4064, which is known to mimic the natural chemical that switches on FXR. GW4064 is owned ...Purdue researchers align nanotubes to improve artificial joints
...of more new bone tissue, which is critical for the proper attachment of artificial joints once they are implanted. Now, the Purdue researchers have shown even more enhanced cell adhesion and growth when so-called "nanotubes" and nanofibers are aligned in the same direction. This orientation is similar to th...Genetic discovery paves way to decode sense of smell in mammals
...omponents of the olfactory machinery that promotes proper targeting of olfactory receptors to the neuronal cell surface, said Hiroaki Matsunami, Ph.D., assistant professor of molecular genetics and microbiology at Duke. By taking advantage of the newly discovered components of the olfactory machinery, the D...Thyroid treatment can trigger homeland security detectors
... to make their patients aware of the need to carry proper documentation following a nuclear medicine procedure," Dr. Zuckier said. "This study suggests guidelines as to how long this documentation should be retained." The U.S. Department of Homeland Security estimates that 10,000 portable radiation dete...JCI table of contents, December 1 2004
...t to the prognosis of patients as well as to their proper treatment and these patients may consequently have to be treated by alternative means. TITLE: TYK2 is a key regulator of the surveillance of B lymphoid tumors AUTHOR CONTACT: Veronika Sexl Department of Pharmacology Medical University of Vienna Vienn...Scientists uncover clues to the mystery of 'gene deserts'
...of multiple gene regulatory elements, guarding the proper complex function of the flanking genes," he said. The variable regions, on the other hand - which make up about two-thirds of the gene deserts and as much as 20 percent of the entire three-billion-base-pair human genome - "can be devoid of bio...US researchers warn of possible fertility risk to men using laptop computers on their laps
... Dr Sheynkin said: "The body needs to maintain a proper testicular temperature for normal spermproduction and development (spermatogenesis). Portable computers in a laptop position produce scrotal hyperthermia by both the direct heating effect of the computer and the sitting position necessary to balance ...Purdue scientists hunt for 'secret X' to treat liver cancer
...at instruct them to grow, differentiate and die at proper times - actions that are necessary for health in highly specialized bodies like our own. Andrisani's team theorized that the X protein was the chemical messenger that caused the liver cells to behave erratically, putting them out of step with healthy...Timing scavenging to prevent age-related blindness
...lection must be precisely synchronized to maintain proper rod and cone cell function. How this synchronous cycle of uptake and digestion is maintained is not completely clear. Nandrot and colleagues now show that, in mice lacking the integrin, the normal burst of uptake activity at first light was complete...DNA breaks and genomic instability: Broken ends stick together
... ends together as the DNA is repaired and leads to proper chromosome segregation in mitosis....JCI table of contents, 3 January 2005
... Insulin secretion is critically dependent on the proper function of a complex network of interactions. In the January 3 issue of the Journal of Clinical Investigation, two articles by Yoshiaki Kido and colleagues from Kobe University and Erik Renstrm and colleagues from Lund University examine the roles o......the antibodies bind to heart cells and disrupt the proper fluctuations of calcium ions that allow the cell to contract, causing a toxic build up of calcium which triggers the death of the cell. It is not known what protein on the cell surface these antibodies are binding to, nor is it clear how these antibo...How do cells travel through our bodies?
... Lissencephaly, in which cells fail to reach their proper destinations. Scientists from the European Molecular Biology Laboratory (EMBL) in Monterotondo have now made a significant step forward in understanding cell motility. The researchers discovered that a molecule called n-cofilin is critical for regula...Study provides insights on why some prostate cancer becomes resistant to hormone withdrawl therapy
...elp the receptor to carry out its functions at the proper time; therefore, lack of interaction between the receptor and the appropriate co-regulators is thought to spur cancer development. Analogous mutant receptors also have been found in human prostate cancers. Researchers wondered what would happen if th...Increased risk of osteoporosis associated with gene that one in five people have
...eaks down estrogen as a normal part of maintaining proper estrogen balance. Within the general population, several variations of the CYP1A1 gene exist, and the variants differ from one another by one or more DNA base pairs. "Previous studies showed that some CYP1A1 variants are linked to estrogen-related c...New RNA polymerase discovered in plants
... one of the four chemical subunits of DNA. Without proper DNA methylation, higher organisms from plants to humans have a host of developmental problems, from dwarfing in plants to tumor development in humans to certain death in mice. Pikaard thinks that Pol IV helps make siRNAs that then direct DNA methyla...Rat brain's executive hub quells alarm center if stress is controllable
...eactions. But this area is too small and lacks the proper sensory inputs to judge whether a stressor is controllable. Many of its inputs come conspicuously from the mid-prefrontal cortex area (medial prefrontal cortex), seat of higher order functions, such as problem-solving and learning from experience. T...