Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
...tivation of the alternative NF-κB pathway. We propose that the acquisition of the mutations identified in our study results in the accumulation of malignant plasma cells beyond the physiological control of the bone marrow compartment. Our results suggest a mechanism by which MM cells can overcome these ...European Science Foundation's Forward Look reaches out beyond the endless frontiers
...ees ( http://www.esf.org/research-areas.html ) may propose topics that might be stimulated by their own scien...ientists or scientific societies are encouraged to propose their topics by approaching either ESF Scientific Committees or ESF Member Organisations. The sugg...News tips from the Journal of Neuroscience
...ditory nerve is severely damaged. Lim and Anderson propose the inferior colliculus central nucleus (ICC) as an alternative site for auditory prostheses. For such devices to work, it is necessary to stimulate at sites that tap into the tonotopic organization of the auditory system; but there's more. In this w...AAAS analysis finds Congress would add billions to FY 2008 R&D investment
...ence. Congressional appropriations measures also propose to meet or exceed President George W. Bushs spending plans for physical sciences research in the American Competitiveness Initiative and for dramatic expansion of spending to develop new craft for human space exploration, says Kei Koizumi, the progra...How a pain in the neck could be bad for your blood pressure
...s - body functions under unconscious control. They propose that nervous signals from the neck could play a key role in ensuring that adequate blood supply is maintained to the brain as we change posture, such as from lying down to standing up. Where such signalling fails, we can suffer problems with balance ...New study demonstrates important role of glia in circadian timing
...paminergic neurons in the brains of Drosophila. We propose that glia participate in the clock control of dopaminergic function and the orchestration of circadian activity rhythms. Glia may communicate with neurons of the circadian system and help to coordinate their outputs, which are critical for the tempor...New research identifies anti-viral protein that may predict who might be at risk to develop lupus
...ve either autoantibody. This led the scientists to propose a two-hit model for the development of lupus. Genetics that cause high levels of interferon-alpha may predispose a person to SLE, but the disease appears only when something else, perhaps an environmental factor, pushes the immune system to the break...Study points to new way to predict death risk from torn aorta
...versity of Michigan Cardiovascular Center experts, propose a new way to predict post-hospital death risk for aortic dissection patients, and a new model for the mechanism behind that risk. Their model focuses on a phenomenon that can easily be seen on modern medical-imaging scans: the presence of blood cl...Picky eating potentially perilous for bats
... this relationship, said Storm. Boyles and Storm propose that dietary specialization may be an important characteristic for conservation biologists to consider when evaluating the extinction risk of bat species. In addition, their study may help develop models for predicting a species risk of extinction. H...Tips from the Journals of the American Society for Microbiology
...sibility of H5N1 viruses, say the researchers. We propose that future selection of H5N1 vaccine candidates among new antigenic variants should take into account the transmissibility of the virus. (H.L. Yen, A.S. Lipatov, N.A. Ilyushina, E.A. Govorkova, J. Franks, N. Yilmaz, A. Douglas, A. Hay, S. Krauss, ...Chronically sleep deprived? You can't make up for lost sleep
... stay awake to avoid danger. Turek and his team propose that this change in the sleep regulatory system is reflective of an allostatic response. In the short term, allostatic responses are adaptive, but when sustained on a chronic basis, such as in their study, an allostatic load will develop and lead to ...Other highlights in JNCI, June 26
... use of surrogate endpoints in clinical trials and propose guidelines for future studies. Overall survival... Cancer Institute in Bethesda, Md., and colleagues propose a different trial design that combines the usual test for response to treatment in all patients with...Competition, loss of selfishness mark shift to supersociety
...om Cornell University and Arizona State University propose a model, based on tug-of-war theory, that may explain the selection pressures that mark the evolutionary transition from primitive society to superorganism and which may bring some order to the conflicted thinking about the roles of individual, kin, ...News tips from the Journal of Neuroscience
...ignificantly influenced by anesthesia. The authors propose that AI responses in the awake animal, although apparently less precise, more accurately represent auditory stimuli. 4. HIF-1 and Cerebral Ischemia Oxana Baranova, Luis F. Miranda, Paola Pichiule, Ioannis Dragatsis, Randall S. Johnson, and Jua...Lessons from the orangutans: Upright walking may have begun in the trees
...ss gaps between trees," said Thorpe. The authors propose an evolutionary scenario that begins as other researchers have envisioned. Somewhere toward the end of the Miocene epoch (24 to 5 million years ago), climate in East and Central Africa became alternately wetter and drier, and the rainforest grew incr...Want to save polar bears? Follow the ice
...wake of the U.S. governments watershed decision to propose listing the polar bear as "Threatened" under the Endangered Species Act, the Wildlife Conservation Society (WCS) is launching a bold initiative to save the Earths largest terrestrial predator, not by following the bears themselves, but the receding s...A living memory chip, black holes on the loose, and a clearer picture of ocean currents
...ically operated neuro-memory chip, the researchers propose that their work implies that chemical stimulation may be crucial to learning and memory formation in living organisms. -KM Black Holes on the Loose Manuela Campanelli, Carlos O. Lousto, Yosef Zlochower, and David Merritt Physical Review Lette...News tips from the Journal of Neuroscience
...ted improvements gained from grafting. The authors propose that patients who fail to benefit from striatal grafts may have damage to ventral striatum or extrastriatal projections....Novel sugar-to-hydrogen technology promises transportation fuel independence
...l Laboratory (ORNL), and the University of Georgia propose using polysaccharides, or sugary carbohydrates, from biomass to directly produce low-cost hydrogen for the new hydrogen economy. According to the DOE, advances are needed in four areas to make hydrogen fuel an economical reality for transportation......, pelted Kennett with questions. The researchers propose that a known reversal in the world's ocean currents and associated rapid global cooling, which some scientists blame for the extinction of multiple species of animals and the end of the Clovis Period, was itself the result of a bigger event. While ge...