Metal-containing compounds show promise as HIV weapon
...very low concentrations, the new molecules inhibit protease in infected cultured human cells with no obvious t...lacarboranes appeared to occupy the portion of the protease used to hold key proteins in place as part of the infective cycle of HIV, preventing the proteases f...JCI table of contents: December 15, 2005
...s. Delivery of this mitochondrial energy-dependent protease improved motor function in the mice and these data show that delivery of an intracellular protein to spinal motor neurons by gene transfer may be useful not only for the treatment of HSP patients but also for those individuals with other forms of per...Standing up to paraplegia with gene therapy
...s. Delivery of this mitochondrial energy-dependent protease improved motor function in the mice and these data show that delivery of an intracellular protein to spinal motor neurons by gene transfer may be useful not only for the treatment of HSP patients but also for those individuals with other forms of per...Viral 'fitness' explains different resistance patterns to aids drugs
...V virus can develop. Yet patients taking unboosted protease inhibitors (PI) do not experience the peak risk of...r author on the study. Both NNRTIs and non-boosted protease inhibitors are potent antiretroviral drugs (ARVs) with demonstrated effectiveness in suppressing the...Gene-specific Ebola therapies protect non-human primates from lethal disease
...ences, may be more potent than anti-virals such as protease inhibitors, which seek to inhibit a protein needed for viral replication. Ebola virus causes hemorrhagic fever with case fatality rates as high as 80 percent in humans. The virus, which is infectious by aerosol (although more commonly spread through...JCI table of contents, February 9, 2006
...e studies suggest that the degradation products of protease activity, in addition to the proteases themselves, may be promising targets for emphysema therapy. TITLE : Elastin fragments drive disease progression in a murine model of emphysema AUTHOR CONTACT: A. McGarry Houghton Brigham and Women's Hospital, ...Computer simulation hints at new HIV drug target
... watched patiently as a few computer-simulated HIV protease molecules squirmed into more than 15,000 slightly ...hat are often seen after failure of treatment with protease inhibitors, drugs that block the action of the enzyme protease and prevent the virus from making mat...Newly discovered small molecules
...ecific sites on the neurotoxin protein, increasing protease activity and enhancing the toxin's effect. In some...ase; before this study, a two-fold activation of a protease was referred to as a state of "superactivation." Proteases are enzymes that act as cellular catalyst...Chemist wins national award for contributions in medicinal chemistry
...is research resulted in the development of the HIV protease inhibitor Crixivan and the HIV reverse transcriptase inhibitor Sustiva. Anderson began his professional career at Merck Sharp and Dohme Research Laboratories where he rose from Senior Research Chemist to Vice President of Chemistry. He retired from M...Enzyme inhibitors block replication of SARS virus
...f inhibitors represents the most potent SARS virus protease inhibitors known today." The path to today's rese...eplicate. Since then researchers have been testing protease inhibitors to lock up this site, known as SARS 3CLpro, and effectively stop the virus from infecting...UCSB researchers discover new biotechnology to identify and engineer substrates for proteases
...y that enables scientists to identify and engineer protease substrates, giving them the means of crafting phar...mited researchers' ability to facilitate or thwart protease action. By identifying substrates, scientists gain the ability to regulate protein function, creatin...Study details hepatitis C ability to block immune system response
...ks the production of type1 interferon by using its protease activity to destroy MAVS. By preventing infected cells from producing interferon, the virus inhibits the body's immune response against HCV, enabling it to persist. "Our new work shows that HCV does not induce interferon-? or antiviral interferon s...Drug combo may reduce protease inhibitor-related hardening of the arteries
...the arteries that accompanies the long-term use of protease inhibitors, a class of drugs that has emerged as t...oside reverse transcriptase inhibitor (NRTI) and a protease inhibitor in combination, it prevented hardening of the arteries often associated with long-term use...New VEE virus protein structure marks first step to developing effective therapy
...lecular biology added, "Now that we know what this protease looks like, we can begin a systematic computer-bas..., and prevent VEE outbreaks from spreading." VEE protease inhibitors would function much like the protease inhibitors taken by people infected with HIV, Watow...Enzyme shreds Alzheimer's protein
...pted by previous studies showing that the cysteine protease CatB--an enzyme that snips apart proteins--closely associated with the amyloid- (A) protein that forms the amyloid plaques, a hallmark of AD. However, those studies had not determined whether CatB was "good" or "bad"--that is, whether it acted to pro...JCI table of contents: September 21, 2006
...res calcium signaling induced by parasite cysteine protease AUTHOR CONTACT:Dennis J. GrabJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.Phone: (410) 614-3917; Fax: (410) 614-1491; E-mail: dgrab@jhmi.edu . View the PDF of this article at: https://www.the-jci.org/article.php?id=2779...FUZEON with investigational HIV drug results in remarkable number of patients achieving undetectable
... treatment-experienced patients with resistance to protease inhibitors, nucleoside analogues and non-nucleoside analogues. Patients received one of three doses of MK-0518 (200 mg, 400 mg or 600 mg) twice-daily in combination with an optimised background regimen of anti-HIV drugs. In the subset of patients w...Molecular 'on/off switch' controls immune defenses against viruses
...unterattack on RIG-I, producing a protein called a protease to disrupt the signaling process, preventing interferon production and allowing viral replication. Just how RIG-I signaling is normally regulated, however, hadn't been known. In the current study, UT Southwestern researchers found that RIG-I and...New HIV test may predict drug resistance
...ot along the genetic code -- position 46 -- of the protease gene results in resistance to the drug indinavir. To assess the test, the researchers analyzed blood samples from three different groups of HIV patients: those who had never received antiretroviral treatment, those who had received treatment but were......e demonstrated that inhibiting the activity of the protease enzyme known as TACE can deprive tumor cells of a ...pies. "We have shown that inhibition of the TACE protease in breast cancer cells blocks the shedding of two critical growth factor proteins and results in an ...