Disabling key protein may give physicians time to treat pneumonic plague
... "Pharmaceutical companies have large libraries of protease inhibitors, so hopefully someone will start the search soon for an inhibitor of PLA that is specific and non-toxic enough to be used as an adjunct treatment," Goldman says. "That might give us enough time to use antibiotics to save patients afflicted...JCI table of contents: February 15, 2006
...om their intense abdominal pain. TITLE: Role for protease activity in visceral pain in irritable bowel syndrome AUTHOR CONTACT: Nathalie Vergnolle University of Calgary, Calgary, Alberta, Canada. Phone: (403) 220-4588; Fax: (403) 210-8195; E-mail: nvergnol@ucalgary.ca . View the PDF of this article at:...European approval of HIV drug darunavir will provide a potent new option with Fuzeon
...ing authorisation in the European Union of the new protease inhibitor (PI) darunavir (boosted with ritonivir) provides physicians with the opportunity to build a potent new treatment combination with the fusion inhibitor, FUZEON. The combination of FUZEON and boosted darunavir has been shown to give treatment...JCI table of contents -- March 1, 2007
... functions. TITLE: Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL AUTHOR CONTACT: Jay W. Heinecke University of Washington, Seattle, Washington, USA. Fax: (206) 685-8346; E-mail: heinecke@u.washington.edu . View the PDF of this arti...Titanium dioxide -- It slices, it dices ...
...that sever the chains at well-known locations. The protease trypsin, for example, cuts proteins at the locations of the amino acids lysine and arginine. Analyzing the residual fragments can identify the original protein. But enzymes are notoriously fussy, demanding fairly tight control of temperature and acid...Misclassified for centuries, medicinal leeches found to be 3 distinct species
... biomedically important developments in areas like protease inhibitors," said Mark Siddall of the American Mus...the discovery and production of anticoagulants and protease inhibitors, some of which may have cancer-fighting properties. That researchers have been mistaken...New NIST reference material for peptide analysis
... a range of purities, a range of molecular masses, protease cleavage sites, and contain tyrosine to enable concentration analysis by UV spectroscopy. ...K-State biochemist contributes to article in Science magazine
... words, corresponding genes. "Many of the serine protease genes have changed so much in the time of the divergence of these species that it was not very easy to identify the corresponding genes among them," Kanost said. He also said most of the research at K-State was done by analyzing gene and protein se...The UAB heads a European research project on proteases and pathological processes
...ar matrix renewing, etc. Without the regulation of protease activity, numerous pathologies can appear, such as...ed will then enable scientists to develop specific protease inhibitors.......xamined, lower levels of SLPI (secretory leukocyte protease inhibitor), defensins, and thrombospondin were found in the tonsils. Altogether, Moutsopoulos et als data suggest that increased expression of molecules associated with HIV binding and entry coupled with decreased innate antiviral factors may rende...