UCR researchers identify key plant enzyme that defends against multiple infections
..., Enrique Rojo, have now shown that this key plant protein contributes to defense against bacterial, fungal a.... They have discovered that mutants lacking this protein have an increased susceptibility to these pathogens. These results have significant influence in th...New risks for bladder cancer identified by MIT team
...ylamines to which a person is exposed react with a protein in the blood, resulting in specific products that can be detected and measured via mass spectrometry. "So what popped out of this was actually pretty startling," Tannenbaum said. "Three of the nine compounds were indeed found to be signific...Embryonic stem cells correct congenital heart defect in mouse embryos
... a relationship between the presence of a specific protein called Id during embryonic growth and the normal d...searchers also found a relationship between the Id protein and stem cells. "We found that stem cells are critically dependent on the Id protein for self-renewa...Emory chemists develop bacteria that may help decaffeinate coffee
...zes theophylline, and turns on the production of a protein known as "cat" which allows the cells to survive in the presence of an antibiotic known as chloramphenicol. Most bacteria die when exposed to chloramphenicol. However, bacteria containing the synthetic riboswitch survive when exposed to chloramphenic...Study describes basic mechanism in cell growth control involving damaged DNA
...radation signaling process is set in motion when a protein is "misfolded" and cannot function properly. Degr... recognized as faulty. "In addition, the cell uses protein degradation as one major way to regulate its own activity, to rid itself of proteins no longer neede...Protein protecting brain from toxins also blocks some chemotherapy from reaching tumors
A protein called Mrp4 blocks the access of the anti-cancer d... a liability in people with brain cancer when this protein also blocks therapeutic drugs from reaching CNS tumors," said John Scheutz, Ph.D., an associate memb...Researchers provide road map for generating B cells from stem cells
...gnals. In the next step, the gene for a regulatory protein known as E2A cooperates with PU.1 to activate another regulatory gene called EBF. EBF and E2A act together to push the lymphoid progenitor towards stage 3, a specified pro-B cell. At this stage, many of the genes expressed in B cells have been acti...Genetic link to risky pregnancy
...eclampsia. The expression of a particular type of protein on the trophoblast in combination with its recepto...mon in women with a history of preeclampsia. This protein combination is expected to deliver a signal that suppresses the NK cells, robbing them of the abilit...Estrogen protects male rats from aortic aneurysms
...male rats contain 2.5 times more destructive MMP-9 protein and 10 times the level of MMP-9 gene expression compared to the same cells from female rat aortas. Known to be involved in AAA formation, MMP-9 is a cell-digesting enzyme that eats away at the wall of the aorta, leaving it vulnerable to expansion and...UNC scientists identify sticky protein in sickle cell red blood cells
...nts for sickle cell disease.The study shows that a protein found on the surface of immature red blood cells, ...in and her co-authors showed that the cell-surface protein Alpha-4Beta-1 is activated by another cell-surface protein, CD47, and that Alpha-4Beta-1 was respons...Technique for genetically modifying blood stem cells brings cure for blood diseases closer
...were derived from the HSCs to make gamma-globin, a protein that acted as a substitute for beta-globin. The re...lity of a single gamma-globin gene to produce this protein in HSCs. The HSCs then produced enough HbF to reverse beta-thalassemia. The success of this techniqu...Channel protein converts vibrations to electrical signal
...n electrical signal recognizable by the brain. The protein forms an ion channel that opens in response to sou...ates, this mechanosensitive channel is formed by a protein known as TRPA1. Certain features of the protein suggest that it may serve double, or even triple, du...Gladstone researchers resolve key Huntington's disease mystery in Nature cover story
...onal death. Scientists know that mutant huntingtin protein is responsible for the disease, but they have not ...huntingtin protein, thereby reducing levels of the protein elsewhere in the neuron, and thus prolonging neurons' survival. The finding suggests that mutant hun...Study using robotic microscope shows how mutant Huntington's protein affects neurons
...lls, researchers have found evidence that abnormal protein clumps called inclusion bodies in neurons from peo...neurons that contained a version of the huntingtin protein that causes HD. The huntingtin was fused to green fluorescent protein, a widely used marker that al...Anti-cholesterol drug treats Alzheimer's disease in mice
...esterol is required in the production of the short protein called A peptide, the building block for the amylo... engineered to have the human form of the aberrant protein that leads to A peptide. Such transgenic mice develop the hallmark pathology of Alzheimer's, includi...Flies have morning and evening clocks
... that express a gene for a circadian photoreceptor protein known as cryptochrome. Starting with those parameters, Rosbash and his colleagues used genetic techniques to selectively deliver cell death genes to ablate specific groups of neurons. They then observed how these genetic deletions affected the flies...Experimental drug prevents vaginal simian HIV transmission in monkeys Science study says
... The experimental drug is a chemically synthesized protein called PSC-RANTES, designed by Science coauthors...uman protein. RANTES is an immune system messenger protein or "chemokine" that induces the movement of human cells and is well known for its antiviral properti...Time-lapse movies show brain cells move like a two-stroke engine
...eurobiology at Rockefeller, also discovered that a protein called Par6-alpha plays an important role in spurr...no difference. Next the researchers looked at the protein Par6-alpha, referred to as mPar6-alpha in mouse cells. Recent studies in other laboratories led the ......e molecular level. Transferrin is an iron-carrying protein found in blood, and is transported into cells via ...cell recognizes transferrin as a natural, harmless protein and picks up the tagged compound without knowing that a bomb artemisinin is hidden inside." ...... mRNA levels mean the brain may not produce enough protein to carry out normal function. The team confirmed its finding using another genetic technique called PCR analysis, which revealed that the most significant differences were in levels of mRNA for one of the FGFs, called FGF1, and for the two receptors,...