Tag: "protein" at biology news
Lag-3 gene dampens immune responses by controlling regulatory T-cell function
... Regulatory T cells, which carry the Lag-3 protein
on their surfaces, interfere with the action of ef...searchers showed that antibodies against the Lag-3 protein
block this moderating effect of regulatory T cells on the effector T cells, allowing the effector ce...
Gene for Joubert syndrom with excessive brain folds discovered by UCSD researchers and Harvard team
... gene called AHI1 that lead to the production of a protein
the scientists named Jouberin. Separate research by a team from Harvard Medical School concurrently identified the same gene in a paper published in the November 2004 issue of the journal Nature Genetics.** Both the UCSD and Harvard studies wer...
OHSU study: Bacterial switching mechanism key to survival
...the help of a phospho-relay system that requires a protein
known as HPr. HPr can itself be phosphorylated in two ways, with one form binding the CCR master regulatory protein, CcpA, and allowing them to then bind a large number of specific DNA sites on the bacterial chromosome. Such binding, in turn, redirec...
New DNA repair enzyme makes mistakes to save lives of cells
... POL-Q last year they reported that because of its protein
structure it belonged to the A family of polymeras...ses that bypass damage. Indeed, comparisons of its protein
sequence to other polymerases in the A family yielded an interesting find: Unlike its cousins, POL-Q...
Molecular mechanism sheds light on neurodegenerative diseases
... disease, they discovered that the disease-causing protein
severely interferes with the working of the protea...living human cells and in real time that the toxic protein
aggregates, in this case caused by mutant Huntingtin, bind to the proteasome machine irreversibly an...
Molecule that helps DNA replicate may make good target for cancer therapy
...ticular protein, called minichromosome maintenance protein
10 (Mcm10), protects the enzyme from destruction a... be unwound. Next, multiple molecules of a certain protein
attach to the strands to keep them from spontaneously sticking together again. Only then can the sta...
Clues to improving TB treatment
... Cell. Details gleaned from an in-depth look at a protein
found in tuberculosis bacteria suggest that the protein
can be disabled when it binds to certain other molecules. With this protein
sidelined, tuberculosis ...
Single genetic defect links many risk factors for heart disease and stroke
...designed to carry and transports it to the site of protein
synthesis. There, it docks precisely with the mess...which can then be incorporated into the elongating protein
chain. The defective base the researchers pinpointed was in the gene for the tRNA that transports t...
Newly discovered protein suggests novel tumorigenic pathway
...ew tumorigenic pathway that is due to defects in a protein
involved in stabilizing PTEN rather than defects i...ns that interact with PTEN. They identified a new protein
that binds to the C-terminus of PTEN and named it PICT-1 ( p rotein i nteracting with the c arboxy...
Researchers discover gene mutations for Parkinson's disease
...his disabling disease." The gene, PARK8, encodes a protein
named dardarin by the researchers, from the Basque word dardara, which means tremor, a major symptom of Parkinson's disease. It was isolated on chromosome 12 by investigators who studied five families with a history of Parkinson's disease who lived i...
NIH funds new bioinformatics resources at UT Southwestern
...in the host's body, leading to changes in gene and protein
activity within both the bacterium and host cell. In order for the infection to persist, the pathogen must overtake the cell, shutting down various signals or setting up decoys in order to survive undetected. Current microorganism databases focus o...
Genetics play role in response to most common asthma drug
...ions in the structure of a gene can affect how the protein
responds to a medication. Many believe that pharmacogenetics will revolutionize health care as it will lead to the development of drugs that target specific molecules more precisely than currently available medications, making them more powerful and...
Gene for common form of Parkinson's pinpointed
...Spain and the United Kingdom. They have named the protein
"dardarin" after the Basque word for tremor. The ...d a kinase. Such enzymatic switches activate other protein
enzymes by attaching a phosphate to them -- called phosphorylation. "Because phosphorylation of prot...
Deciphering an autism mystery
...2 as an autism gene. The EN2 gene encodes a protein
called a transcription factor that binds to cells' DNA to control the expression of dozens or even hundreds of other genes. Therefore, a variation in EN2 could have far-reaching effects on brain development and behavior. The next step in this ...
Pesticides may promote Parkinson's disease and exercise may offer protection
...e been studying the seemingly critical role that a protein
called cyclooxygenase type-2 ( COX-2) plays in the...e researchers also showed that the amount of COX-2 protein
was higher in patients with Parkinson's disease than in those without the disease. "These results s...
Soaking up signal: Endocytosis controls spreading and effective signaling range of Fgf8 protein
...developing tissues are extremely sensitive to such protein
signals, and thus the range of these signals withi... but the mechanisms by which the spreading of Fgf8 protein
is controlled in a field of target cells are unknown. In seeking to better understand how this signa...
Singled out: Spotting mutant neurons in normal brains offers clues to Fragile X
...at fail to express appropriate levels of Fragile X protein
are structurally abnormal and make defective conne... cells that either completely lacked the Fragile X protein
or overexpressed it, the fluorescent protein
label allowing the entire architecture of these neurons...
Sandbagging cancer in the bloodstream
... Some of the most metastatic tumor cells secrete a protein
known as vascular endothelial growth factor (VEGF). VEGF stimulates a protein
called Src kinase, which causes proteins known as cadherins to disengage from each other. Normally, ...
Potential new oncogene may be missing link in cancer-causing chain
St. Louis, Oct. 25, 2004 -- High levels of a protein
called LRP6 can make cancer cells more aggressive,... position on the surface of cells, Bu believes the protein
may be a good target for drugs that decrease its function to slow down or prevent the progression of...
Children's Hospital Boston geneticist awarded for research on muscular dystrophy
...and encodes microsomal transfer protein, or MTP, a protein
involved in the metabolism of fats. Kunkel is now expanding on this work to find additional longevity genes. "With new technology, we can now analyze 10,000 genes at once, compare patterns from individual to individual, and look for genetic variat...
1 2 3 4 5 6 7 8 9 10