Protein 'chatter' linked to cancer activation
...e disorder, and Nijmegen breakage syndrome. The proteins whose deficiency is responsible for these three hu...ve found that the communication link between these proteins and a protein crucial for maintenance of chromosome ends is either missing or nonfunctional in these...Gene regulation, not just genes, is what sets humans apart
...umans. These regulatory stretches of DNA are where proteins bind to the genome to initiate a genes function. And it is here that evolution has apparently fine-tuned the performance of genes, Wray said, resulting in the dramatic differences in the human brain. Though many studies have looked for significant...Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
...s, and found DNA variants in genes that encode for proteins involved in energy production. Thus, for the first time, they were able to directly link inherited variation in the mitochondrial genome to metabolic markers for type 2 diabetes. Our study highlights the role of mitochondrial DNA variation in comm...OHSU turns mouse into factory for human liver cells
...e that makes human blood clotting factors, all the proteins the liver makes, human bile, everything." The mice also retain their unique traits for multiple generations, and each mouse can be implanted with human liver cells at least four times. Grompe estimates that each round of implantation can generate m...Genetic variation helps to understand predisposition to schizophrenia
...type 4 one of the six known types of Neuregulin 1 proteins in the brains of patients with schizophrenia. T...ely understood but the other types of Neuregulin 1 proteins are involved in controlling how the brain develops and works in adults. In this study, Law and colle...Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
...eys research is to identify ways in which specific proteins accumulate in the brain and identify new drug targ...study will focus on the removal of the accumulated proteins by manipulating a class of proteins called molecular chaperones. These chaperones help in the proces...Antioxidant overload may underlie a heritable human disease
... response, including higher activity of heat shock proteins that have been documented in human heart failure, Benjamin explained. Such stress responses yield reactive oxygen species, triggering antioxidative pathways to kick in. In the diseased animals, however, that pathwayin which oxidized glutathione is re...A study by the MUHC and McGill University opens a new door to understanding cancer
...udy we have clarified the structure of some of the proteins involved and their connections, which allows us to... molecule is to clean house. It attaches itself to proteins that must disappear and triggers their degradation; in doing so, it allows a number of mechanisms to...JCI table of contents: Aug. 9, 2007
...SNP for acute myeloid leukemia Tumor suppressor proteins are so called because their functions oppose the development of cancer. Studies in mice indicate that the protein PU.1 is a tumor suppressor. Mice lacking a specific portion of the DNA (known as the upstream regulatory element; URE) that controls the...New test improves detection of liver cancer
...o particular sugar groups that appear on the blood proteins varied according to the stage of the disease. Furthermore, these values correlated with the size of the tumor. The ratio of these values forms the basis of the new blood test. The researchers were able to make the correct diagnosis in 70% of the cas...Research aims to identify markers for menopausal women at risk for deadly blood clot
...The hormone trials conducted thus far, focusing on proteins in blood coagulation, have not yet led to a risk profile, thereby precluding identification of women at risk. Now, a team of Mayo Clinic researchers, led by Virginia Miller, has developed a novel concept that uses blood platelets to define thrombotic...Weizmann Institute scientists discover a control mechanism for metastasis
...uantities and some in less. To understand which proteins are modulated by the growth factor and the nature ... protein level that went up or down, one family of proteins stood out. Tensins, as theyre are called, are proteins that stabilize the cell structure. But to the...News tips from the Journal of Neuroscience
...f syntaxin1 and thus occludes binding of the SNARE proteins SNAP-25 and synaptobrevin. However, Munc18 cannot be simply a negative regulator of exocytosis because vesicles fail to dock in its absence. To address this issue, the authors expressed mutant variants in chromaffin cells from Munc18 null mice and us...High-intensity ultrasound may launch attack on cancer, wherever it lurks
...ive, it may need to recognize not only the surface proteins of cancer cells, but some of the other proteins locked inside those cells, which Zhong called danger signals. The researchers found in mice with c...Penn researchers discover how key protein stops inflammation
...ular system of checks and balances, where cellular proteins are flagged for disposal. During exposure to infection, Bcl-3 appears to overrule the p50 ubiquitination, stabilizing the presence of p50 on DNA and halting inflammation. Our study identifies another layer of information that controls the inflammat...Taking a supplement of glycine helps prevent degenerative diseases such as arthrosis or osteoporosis
...tial amino acid used by the organism to synthesise proteins and is present in foods such as fish, meat or dairy products. The study, carried out at the Cellular Metabolism Institute in Tenerife and at the Department of Biochemistry and Molecular Biology of the University of Granada by Doctor Patricia de Paz...ASBMB taps 8 scientists and 1 politician for top awards
...ntists. Scotts work on the AKAP family of scaffold proteins has transformed the field of intracellular signaling. He has also been an exemplary trainer of graduate students and postdoctoral fellows who have gone on to make their own contributions to the field of signal transduction. Michael F. Summers (U...American Chemical Society's Weekly PressPac -- Aug. 1, 2007
...various fractions enriched in bran, wheat germ and proteins that could be sold or utilized for the extraction ...g, in which blood tests are used to analyze single proteins and multiple fingerprint protein patterns that are present, including proteins that can serve as bio...Link identified between Alzheimer's disease and glaucoma
... scientists have shown for the first time that key proteins involved in Alzheimer's disease are also implicated in glaucoma, the major cause of irreversible blindness worldwide. Research carried out at the UCL Institute of Ophthalmology and funded by the Wellcome Trust has also shown that novel drugs being tr......sualize what specific particles like milk fats or proteins look like on their own. We can also visualize what a medium would look like if one particle type were missing. Having knowledge about the visual effect caused by each type of particle is incredibly valuable in many different contexts, explained Jepp...