Dietary preferences and patterns may be linked to genes
...at Tufts. Nutrients from the foods we eat activate proteins in our body, which in turn bind to promoter regions, like the APOA2 promoter. These promoters then tell our genes how to behave, he explains. Understanding these relationships may help to shape future recommendations for prevention of undesirable hea...Malaria and Epstein-Barr virus linked to pediatric cancer in Africa
... Their results suggest that P. falciparum-derived proteins can lead to a direct reactivation of EBV during acute malaria infection, increasing the risk of Burkitt lymphoma development for children living in malaria-endemic areas....Super fruit fly may lead to healthier humans
...d used by his research group to make theinhibiting proteins opens the possibility of developing a lot of newth...ss many species, including humans. Receptors are proteins that transmit signals across a cell membrane. In thefruit fly, Roberts and his team manufactured sho...Largest synthetic gene ever built offers insights into anti-malarial drug resistance
...ent heme from crystallizing. "We know these mutant proteins are controlling pH across two different membranes, but we don't yet know exactly how they are doing it," Roepe says. "Still, knowing the pH values can help pharmacologists and chemists redesign a molecule to take advantage of these changes."...University of Pittsburgh scientists find new contributor to aggressive cancers
...tegrin 7 belongs to a major class of cell membrane proteins that play a role in the attachment of a cell to the extracellular matrix (ECM), which is the material that holds cells within a particular type of tissue together. Integrins also help cells attach to one another and are involved in transmitting chemi...New clues to stroke role in Alzheimer's
...BACE levels, the researchers found that one of the proteins snipped apart by caspase activity is GGA3. This protein is an adaptor protein necessary for shepherding BACE to the cells garbage disposal machinery, the lysosome. The researchers found that caspase snipping of GGA3 not only eliminates GGA3's ability...Blocking beta1-integrin to treat cancer
...ix and preventing them from migratingaround. These proteins are also important for cell survival and proliferation, and have beenshown to contribute to tumour progression in several ways. Angelika Kren and colleagues investigated transgenic mice with insulinomas tumours of pancreatic beta cells, which metas...Study shows big power of small RNAs, not just proteins, in halting cancer
...in surrounding healthy cells. Most suspected that proteins would be revealed as key to the power of p53, but this latest research published June 6 by Nature now identifies miRNAs as a critical force behind the anti-proliferation potential of p53. Expression of most miRNAs is reduced in tumors, suggestin...New algorithms classify outcomes of nonsmall cell lung cancer patients
...he drugs and is based on the pattern of a group of proteins in the patients blood serum. The authors developed the algorithm on a group of patients with known outcomes then tested it on pretreatment serum for independent validation and control groups. The researchers found that the algorithm could classify...Origins of nervous system found in genes of sea sponge, report scientists at UC Santa Barbara
...rbara. Even more surprising is that the sponge proteins have signatures indicating they probably interact with each other in a similar way to the proteins in synapses of humans and mice, said Oakley. This pushes back the origins of these genetic component...New screening method to help find better biofuel crops
...aman imaging technology to study animal and insect proteins and said it wasnt a big leap to study plant material. There is obviously a lot of interest in biofuels right now, she said. Given the number of good researchers on campus working in this area, it was an easy decision to get involved in this projec...The insect vector always bites twice
...ing in the arthropod vector saliva the immunogenic proteins responsible. They called on immunological techniqu...resence of antibodies targeting specifically these proteins contained in an extract of total saliva of the culprit vector. This approach, based on the studie...Simulations unravel outer membrane transport mechanism
... provide a rare window on the complex interplay of proteins involved in the active transport of materials acro...elp researchers study the interactions of multiple proteins in complex systems, such as the TonB-dependent transporter, Gumbart said. As we get more computati...Breakthrough for treatment of fatal heart condition
... the body, known as REST, can halt the rise of the proteins causing cardiac hypertrophy, which, for the first time, offers an approach to treating the cause of heart hypertrophy rather than its symptoms. The challenge is now to find a therapy that controls the source of the problem on an ongoing basis. If ...Origins of nervous system found in genes of sea sponge
...Barbara. Even more surprising is that the sponge proteins have signatures indicating they probably interact with each other in a similar way to the proteins in synapses of humans and mice, said Oakley. This pushes back the origins of these genetic component......ers of his team discovered whats needed to qualify proteins for exosomal travel. Surprisingly, all thats nee... chemicals to normal human cells that force nearby proteins together into a clump, and this was enough to get them sent out of the cell in exosomes. If they add...JCI table of contents -- June 1, 2007
...ber of sialic acid residues on critical glomerular proteins such as podocalyxin, which was associated with a b...uctures. This breakdown allows red blood cells and proteins that are normally retained in the glomerulus, to pass into the urine. They went on to show that diet...Cellular message movement captured on video
... of a cow aorta. They added genetically engineered proteins tagged with red and green fluorescence markers to ...can now see the dynamics of how paxillin and other proteins move inside the cell with new fluorescent labels and live-cell video microscopy, said Chien, directo...Description of a gene implicated in the development of Fanconi anemia and predisposition to cancer
...e, is of important biomedical interest because the proteins that are implicated with it are also associated with different vital functions and cancer suppression. The work covers the molecular studies of all the D2 Fanconi patients (those affected by the Fanconi anaemia that present alternations of this gene)...Blood test may help signal tumor's remission, return in throat cancer patients
A blood test that detects proteins commonly released by a growing tumor could one day...nts who showed a decline in several cancer-related proteins following chemotherapy and radiation treatment were more likely to remain in remission, while those ...