Anti-cholesterol drug treats Alzheimer's disease in mice
... although "It remains to be shown that statins can provide significant cognitive benefit for AD patients with normal serum cholesterol." Although CP-113,818 has not been tested in clinical trials, another ACAT inhibitor, avasimibe, developed by Pfizer, is now in final clinical trials as a treatment for vascu...Laboratory test of evolutionary theory confirms importance of links between populations
...n a series of chemostats--glass culture tubes that provide nutrients and oxygen and siphon off wastes. In one set of chemostats the communities remained isolated from one another. In another set, Forde periodically made a series of transfers between communities, sucking up a pipette full of bacteria and viru...Muscling in on a deadly cancer
...urgery and radiation." Capecchi says the studies provide evidence that the cancer may originate in mature or nearly mature skeletal muscle fibers. That is controversial because satellite stem cells cells that become new muscle long have been suspected of giving rise to rhabdomyosarcoma. "If we know ...NHGRI seeks next generation of sequencing technologies
...hnologies that, within five years, are expected to provide the power to sequence a mammalian-sized genome for...p the system to increase throughput, cut costs and provide the power to sequence genomes of organisms for which no framework of genomic data exists. In order t...How to use math and a CT scanner to see how trees intercept light
... that he co-ordinated the creation and start-up of provide researchers in plant, soil and animal sciences with an amazing tool for pioneering research in these areas....The CF Foundation urges all states to include newborn screening for cystic fibrosis in test panels
...on of CF on newborn screening test panels and will provide guidance on optimum test procedures and the elemen...ants to its accredited care centers. These centers provide state-of-the-art specialty care and the opportunity for infants to benefit from medical advances. In...Using fruitflies to examine alcohol tolerance
...rance. In sum, two different lines of experiments provide pharmacological and genetic support for the idea that rapid and chronic tolerance may utilize at least partially distinct pathways in flies." "The most provocative result in this study is the suggestion that rapid and chronic tolerance are mechanis...Purdue chemists give an old laboratory 'bloodhound' a sharper nose
...a device well known to chemists for its ability to provide information on the composition of unknown substances. Mass spectrometers, essential tools in any modern chemistry lab, are often used by law enforcement to test suspicious-looking residues that could indicate the presence of explosives or drugs insid...Scientists explain how morphogens work
...orphogens work by "diffusion." "These findings provide new insight into the understanding of the mechanisms that control the function of morphogens," Lin said. "In order to treat diseases related with morphogen malfunctions, scientists must first understand the mechanisms that trigger diseases. This unde...Antibiotic identified as potential anti-cancer candidate
...in's inhibition of human Pdf. The researchers now provide the evidence to support this theory. They show that human Pdf is active in the mitochondria and is essential for cellular growth and proliferation. They have designed and created a class of new actinonin-based Pdf inhibitors, and have demonstrated ...Normal cells in tumors may aid cancer growth
...ers. The genetic changes in stromal cells also may provide new targets for future anti-cancer drugs and present a new strategy for treating and preventing cancer, says Eng, a recipient of the Doris Duke Distinguished Clinical Scientist Award. The study is published in the Oct. 15 issue of the journal Can...Horse auction raises $75,000 for research
...etween 25 and 30 foals annually. The growing foals provide researchers an opportunity to study how nutrition affects metabolism and skeletal development. The research objectives are to develop pastures and pasture supplements that improve the reproductive efficiency of mares, optimize growth in the young h...Scientists identify new cause of obesity
... the protein to regulate appetite. "These findings provide a whole new way of thinking about how hormone receptors could cause disease, and suggest different types of drugs for treating these diseases," said Bruce Conklin, MD, UCSF associate professor of medicine and also of cellular and molecular pharmacolo...UCSD medical researchers use brain cell transplants to correct muscle spasms after aneurysm surgery
...d the transplanted neuronal cells. "These findings provide conclusive evidence that transplantation of well defined human neuronal cells into a specific region of the spinal cord can be an effective treatment for spasticity in cases of ischemic spinal cord injury," said the study's lead author, Martin Marsal...UCLA scientists discover new way to fix defective gene
...ation," noted Lai. "We hope that our findings will provide a solid first step to gene-based therapy for this group." According to Gatti, many aminoglycosides are already approved for clinical use by the FDA and could quickly become available for testing in A-T clinical trials. "Our next step will be to build...New version of tumor-suppressor linked to progression of childhood cancer
...at stimulates progression of neuroblastoma and may provide a likely target for new anti-cancer therapies. Neurotrophin tyrosine kinase receptor type I (TrkA) responds to nerve growth factor and plays a key role in the development of the nervous system. Mutated TrkA has been associated with many human cancers...Zebrafish may offer researchers powerful new tool for studying innate immunity
...ystems innate and adaptive. Innate immune systems provide a first line of defense against foreign microorganisms. But, humans and other jawed vertebrates have also evolved more customized or adaptive immune systems, which use an arsenal of antibodies and T-cell receptors to fend off diverse pathogens and pr...Peakadilly nv biopharmaceutical firm created
... helped by it. Proteomics can also provide insight into the origin and progression of diseases. The analysis of the effect of a drug on the proteome enables researchers to understand which protein(s) the drug acts upon. Until recently, however, there was no efficient way to study the proteome...Urine testing might prove to be an alternative screening test for cervical cancer
...st Africa has shown that a simple urine test might provide an alternative to Pap screening for cervical cancer. In most of the world, cervical cancer is the second leading cause of cancer-related death among women. The routine way to screen for cervical cancer is through Pap screening and pelvic exams. "Mo...High fiber intake reduces estrogen levels in Latina women, according to researchers
...e been linked to breast cancer, this finding could provide a significant step toward preventing breast cancer. Their findings are being presented at the American Association for Cancer Research (AACR) third annual International Conference on Frontiers in Cancer Prevention Research in a poster presentation ...