By impounding iron, FHC foils cell suicide, fuels inflammation
...ells from radiation and chemotherapies designed to provoke tumor cell suicide. Drugs that inhibit NF-kB are already in use for inflammatory bowel disease and certain cancers, such as Hodgkin's lymphoma and multiple myeloma. But the tasks controlled by NF-kB are so wide ranging that blocking them globally ca...U of T researcher links schizophrenia, gene mutations
...e to move, think and feel. "The altered genes may provoke the brain to respond and compensate, and compensation often involves the dopamine system going into high gear," says Seeman. "The brain knows about mistakes, and to protect itself, it makes sense for the compensation to re-adjust the dopamine system ...Inflammatory molecules released by pollen trigger allergies
How do pollen particles provoke allergic reactions? A new study in the February 21 issue of The Journal of Experimental Medicine puts some of the blame on bioactive molecules that are released from pollen. These molecules bind to immune cells and cause them to launch a typical al...Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
...e genes through lateral transfer. "This study will provoke interest in what secrets may lie undiscovered in the sequences of other supposedly 'simple' amoeba genomes." Named for its effectiveness in killing other cells, E. histolytica was long considered to be a 'primitive' organism originating from t...UCLA scientists store materials in cells' natural vaults
... will be compatible with living cells and will not provoke an immune reaction. Previous efforts have relied upon viruses or artificial chemicals to house and deliver drugs or other substances to targeted cells. RESEARCH: Scientists at the David Geffen School of Medicine at UCLA have exploited thousands ...UCSD researchers maintain stem cells without contaminated animal feeder layers
...ls were to be transplanted into people, they would provoke an immune system attack eliminating their therapeutic value. While several laboratories have attempted to grow stem cells in alternative cultures, problems have remained. In some cases, human feeder layers were developed but this added another measu...New insights into how Huntington's disease attacks the brain
...icits toxic interactions from neighboring cells to provoke the fatal brain disorder. The May 5 edition of Neuron reports the findings. "This is really important because most current disease models and drug development efforts rely on the assumption that Huntington's disease arises from within the target b...Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
...onment and that small, random physical changes can provoke an amplified response in the biology in ways that may not be easily or symmetrically reversed. These measurements show that asymmetrical and even irreversible ecological change is possible." Irreversibility means that if the ecosystem changes drama...Woods Hole Research Center plans controlled burn in Amazon rainforest
...es in the canopy; longer, more intense dry seasons provoke leaf thinning; and both of these changes allow the litter to become dry enough to sustain a fire. Once a forest has burned a first time, the combination of a more damaged forest canopy and a stock of larger fuel from trees killed by prior fires make...The link between fasting and acute attacks of porphyria
...hough drugs like alcohol and barbiturates can also provoke an acute porphyria attack, PGC-1a is not involved in attacks brought on by barbiturates, Spiegelman and colleagues found after examining the effects of phenobarbital in both normal mice and mice without PGC-1a in their livers. Acute porphyria attacks...Attacks of King George III's madness linked to key metabolism molecule
... of George III's hair contained arsenic, which can provoke porphyria attacks. The authors of that report suggested that, ironically, he may have been exposed to arsenic contamination of a substance his doctors gave him as treatment. PGC-1 alpha is a "transcriptional coactivator" that acts as an on-off switch...Muscle of obese 'programmed' to amass fat, genetic study finds
...ich obesity-induced modifications in gene activity provoke irreversible perturbations in SCD1 gene regulation." "While these findings may be somewhat discouraging news for those wishing to reverse obesity through dietary interventions, they also highlight the importance of exercise," Muoio said. Exercise is ...Carnegie Mellon study finds that facial expressions reveal how the body reacts to stress
...hat all negative emotions, such as fear and anger, provoke the same psychological and biological reactions. This paper builds on a line of work led by Lerner showing that anger triggers feelings of certainty and control as well as optimistic perceptions of risk. A landmark study by Lerner found that American...Common properties in the genes implicated in the development of cancer
...they appear." Characterizing the processes which provoke breakage is one of the issues which arouses greatest interest among the scientific community. In addition, according to this researcher, "understanding the mechanisms by which cancer develops could mean a great advance in the struggle against this d...Manipulating single cell receptor alters animal behavior
...ts, both stimulated by the same cell receptor, can provoke different behaviors in mammals. The broad implicat... kidneys and lungs produce enzymes that eventually provoke production of angiotensin. It previously was known that angiotensin has robust behavioral effects o...Taking a bite out of a fellow worker helps wasps recruit new foragers
...actions. O'Donnell said the biting did not always provoke an individual to begin foraging immediately, noting the biting seems to have a cumulative effect. Some insects were bitten multiple times for hours before leaving the nest to forage. "Going off the nest to forage, where they are exposed to all kind...... some form of mild distress, such as a biopsy, may provoke a response that makes conditions in the uterus favorable for implantation. Dekel and her team are now looking for the exact mechanisms involved when an unreceptive uterus turns receptive following local injury. They are conducting both animal studies...Avoiding punishment is its own reward
... that avoiding bad outcomes and receiving a reward provoke a similar response in the medial OFC. Avoiding negative outcomes and receiving rewards amount to the same thing for the brain: achieving a goal. Reward serves as an external signal that reinforces behavior associated with a positive outcome, Kim e...Engineer ramps up protein production, develops versatile viral spheres
... into the bloodstream with the hope that they will provoke a strong, albeit general, response by the immune system. The process is akin to advertising a product to a random audience and hoping some consumers become interested. With an engineered capsid, in contrast, a vaccine maker could attach a very spec......iliation in a given species rather than those that provoke avoidance or attack. To test the idea, they conducted two additional experiments. In the first, territorial violet-eared waxbills were exposed to their pair bond partner. As predicted, and in contrast to the response seen after exposure to a bird o...