Thumbnail sampler of 10 diverse physiology papers from IUPS 2005
...re efficiently with lower amounts of damaging free radicals a problem during aging. They believe that the novel mechanism of estrogen action may help explain why pre-menopausal women have a lower incidence of stoke than men of the same age. Funding: NIH "PKC beta/Egr-1: a crucial axis in atherosclerosis." ...VCU research shows Viagra prevents anti-cancer drug induced heart damage
... for cellular function. According to Kukreja, free radicals generated in the mitochondria of cardiac cells by DOX lead to the break down of regular cellular function, resulting in programmed cardiac cell death. Over time, cell death has been linked to decreased heart function or heart failure. DOX is an effec...Antioxidant-rich diets reduce brain damage from stroke in rats
...ch scientists say may counteract the burst of free radicals involved in the cascade of brain cell death triggered by an ischemic stroke. An excess of free radicals can damage cellular lipids, proteins and DNA. The supplemented diets also contained anti-inflammato...Vitamin E loss through smoking increases health risks
...ss. "Cigarette smoke is an oxidant, creating free radicals that are associated with increased oxidative stres...one of the first lines of defense against the free radicals generated by cigarette smoke." It has been known for some time that cigarette smoking reduced blood...NIH awards Georgia Tech/Emory $11.5 M for nano cardiology research
...l also develop ultra-sensitive probes for the free radicals inside cells and biomolecular constructs for molecular imaging and therapeutics. The program will integrate the biomedical engineering strengths of Georgia Tech and the cardiology expertise of Emory University School of Medicine. The new program is ......s low oxygen, low glucose, or the presence of free radicals and, from this, can induce a check on replication through p53, acting in effect as a tumor-suppressor." For this study, the investigators looked at noncancerous mouse cells called fibroblasts to see how normal cells work and what they do physiologic...Researchers extend mouse lifespan by protecting against free radicals
... including DNA. Some researchers believe that free radicals could contribute to or hasten heart disease, cance...f metabolism and it can be a the precursor of free radicals that can damage the cell. The damage can in turn lead to more flaws in the cell's chemical processes...Atmosphere may cleanse itself better than previously thought
...his way - producing natural air cleaners called OH radicals - the chemicals the team studied have for the first time been observed to produce air-scrubbing OH radicals at low ultraviolet wavelengths. This observation has eluded science primarily because photochemistry...A radical solution for environmental pollution
... other potentially harmful chemicals known as free radicals to degrade the toxins they live on. Such insights could lead to new ways of engineering bacteria to clean up environmental messes, said associate professor of chemistry E. Neil Marsh, who did the work with postdoctoral fellow Chunhua Qiao. Free rad...Joslin scientists confirm link between PKC enzyme and kidney disease in diabetes
...ccumulation of destructive molecules, such as free radicals - was three times higher in the nondiabetic PKC beta 2 transgenic mice than in normal mice. These findings demonstrate that chronic activation of the PKC-beta 2 isoform, induced by hyperglycemia, is at least partially responsible for the development ...Purdue scientists may have found key to halting spinal cord damage
...atized cells at increased risk of damage from free radicals that oxidize the tissue, but the cells also spill chemicals that actually help the free radicals to launch repeated attacks," said Shi, who is an associate professor of neuroscience and biomedical ...UF study finds cell mutations that lead to apoptosis may contribute to aging in mammals
...lack of exercise -- not oxidative stress from free radicals -- may be a key factor in the aging process. The s...s instrumental in the biochemical analysis of free radicals and apoptosis in the study. In the mutated mice, that ability was impaired so the cells could not re...Elderly mice yield clues to the process of growing old
...of reactive, cell-damaging molecules known as free radicals -- is responsible for the aging process. According to the new Science report, markers of oxidative stress did not parallel the accumulation of mitochondrial genetic mutations. Instead, the group found evidence that indicated accelerated cell death,...One hit of crystal meth causes birth defects: U of T study
...eveloped the enzymes that protect it against free radicals highly activated, destructive oxygen molecules that have been implicated in cancer and neurodegenerative diseases, says Wells. This vulnerability lasts from the embryonic stage through the later fetal period, times when organ structures and mental f......gen and can lead to the production of harmful free radicals which can damage cell membranes and DNA. "It's a...about 1,000 times faster than standard EPR. "Free radicals are dangerous chemicals and dangerous chemistry takes place rapidly," said Norris. "This lets us se...Wanted: Companies to license life-saving breath test developed at NJIT
...red electrons that make them highly reactive. Free radicals oxidize cell membranes, releasing the volatile organic compounds that are exhaled in the breath. Phillips developed the world's most sensitive breathalyzer by capturing and concentrating volatile organic compounds in the breath onto activated carbon,...Dangerous tricksters: Some bacterie use immune cells to reproduce
...concentrated: the phagosome is flooded with oxygen radicals and acid. Another kind of membrane bags, the lysosomes, merge with the phagosome and confront the microbe with highly reactive digestive enzymes. A few hours after the first alarm bells have rung there is nothing left of the bacterium, and the potent...Phytochemicals may protect cartilage, prevent pain in joints
...fy certain cancer-causing agents and damaging free radicals in tissue, including cells that line blood vessels. He has isolated compounds in edible plants that boost production of phase 2 enzymes. These phytochemicals can be found in cruciferous plants, including broccoli. Talalay provided one of the phase 2 ...Joslin study sheds light on birth defect cause in pregnant women with diabetes
...lucose levels boost an embryo's production of free radicals products of metabolism that cause oxidative stres...on of high levels of antioxidants which keep free radicals from wreaking cellular havoc prevented the decrease in Pax3 expression and birth defects in embryos......diation, other environmental carcinogens, and free radicals from the cellular metabolism. DNA damage ranges from one or a few altered nucleotides in a single strand of the double helix, to breaks in one or both strands and crosslinks between the two strands. To prevent accumulation of mutations and the produc...