Tag: "rapamycin" at biology news
News tips from the Journal of Neuroscience
...on of two pathways. The kinase mammalian target of rapamycin
(mTOR) enables translation of terminal oligopyrimidine messenger RNAs, which in turn encode translational machinery proteins such as elongation factor 1A. Expression of these proteins increased in an mTOR-dependent manner minutes after the authors in...
UC Davis breast cancer researchers report new insights into ductal carcinoma in situ
... professor of pathology, found that the antibiotic rapamycin
quickly induced apoptosis, or rapid cell death, in some but not all MIN cell lines. The researchers' next step will be to use micro-array genetic analysis to determine which genes were expressed in the surviving malignant cells. Such genes could be p...
Scientists use gene signatures to match cancer and other diseases with potentially effective drugs
...iatrics at Harvard Medical School. "Then we tested rapamycin
to see if it made the ALL cells more sensitive to ...ding that a clinical trial is being planned to try rapamycin
in children who have had recurrences of initially successfully treated ALL. Moreover, the comparis...
Chemical genomic screening identifies novel therapeutic strategies for cancer
...proach. This comparison revealed that the compound rapamycin
is an agent capable of potentially reversing the G...gnature. The researchers further demonstrated that rapamycin
modulates a signaling molecule linked to cell death and suggested that combination therapy with rapa...
Distinguishing friend from foe in the battle against cancer
...shows that resistance to the chemotherapeutic drug rapamycin
is mediated by the survival factor NF-kB. Rapamyc...o explained a paradox: TSC null cells treated with rapamycin
actually survived cellular insult better than untreated cells-a highly inauspicious outcome if the g...
Novel pathway identifies rapamycin as tumor angiogenesis inhibitor
...which we hypothesize are in part due to effects of rapamycin
on endothelial Akt activation. These findings indicate a possible clinical utility of rapamycin
as an angiogenesis inhibitor and support a novel pathway for rapamycin
action via Akt inhibition. Al...
Rapamycin shown to inhibit angiogenesis
...d blood vessel changes. In subsequent experiments, rapamycin
reduced tumor growth and vascular leak in a mouse ...dministration (FDA) as an immunosuppressant agent, rapamycin
is being tested in clinical trials as a cancer treatment. "These new findings suggest that we sh...
Targeted virus compels cancer cells to eat themselves
...ng a molecular pathway -- the mammalian target of rapamycin
(mTOR) pathway -- that is known to prevent cellular self-cannibalization. The result was a huge difference in tumor volume among mice with subcutaneous malignant glioma that got hTERT-Ad and those that received a different, non-replicating virus. ...
The American Association for Cancer Research provides support for promising cancer scientists
...ject: A pharmacodynamic study of pre-prostatectomy rapamycin
in men with advanced localized prostate cancer Recipient: Rupal Satish Bhatt, Ph.D., M.D., Beth Israel Deaconess Medical Center, Boston, Mass. Project: ANGPTL4 as a potentially novel biomarker and/or therapeutic angiogenic target for renal cell can...
Scientists discover that widely available drug also helps fight kidney disease
...ogy at UCSB. The scientists studied the effects of rapamycin
on mice. "When we administered rapamycin
to mice with PKD and looked at their kidneys afterwards, we were absolutely amazed," said Weimbs. "T...
Recycled or revamped therapeutics find novel anti-cancer applications
... pathway." While thousands of patients already use rapamycin
for immunosuppressive needs after transplant surgery, the opportunity exists to treat cancers that depend on the PI3/AKT pathway for energy needs. On the other hand, PIM inhibitors may effectively kill the alternative addictive pathway that cancer ce...
PTEN, TSC2, and tumorigenesis
... uncontrolled mTOR activity, as the mTOR inhibitor rapamycin
can restore Akt activation. Our findings that rel...sis complex, raises some concern about the use of rapamycin
to treat this disease. Pending the results of ongoing clinical trials with rapamycin, these studies...
Researchers add new tool to tumor-treatment arsenal
...drug rapamycin. Used in organ transplant patients, rapamycin
and its derivatives have shown promising anti-tumor activity in phase I and II clinical trials. RAD001 lowers the amount of DNA-damaging agent needed by blocking p53's DNA-repair function, automatically killing the cancer cells when agents like cisp...
Researchers identify target for cancer drugs
...udied as the target for the immunosuppressant drug rapamycin
(in fact, mTOR is an acronym for "mammalian target of rapamycin"). In July of 2004, Dos Sarbassov, a scientist in Sabatini's lab, discovered a new protein that mTOR interacts with called rictor, but he wasn't yet sure of what these two proteins do to...
Newly discovered protein suggests novel tumorigenic pathway
...e, then this new type of tumor may be treated with rapamycin
or related drugs that are often used in cancers resulting from PTEN loss of function....