Scripps Research study reveals new function of protein kinase pathway in tumor suppression
...gen-activated protein (MAP) kinase is required for ras to induce senescence in cell culture. "After th...he researchers found was that PRAK is required for ras to induce senescence in vitro in normal cells derived from a mouse. They also did an experiment to s...ACS News Service Weekly PressPac -- August 23, 2006
... cells that lead to cancer. The gene that produces ras gained notoriety as the first known oncogene -- a gene that can cause cancer. Six years ago, Japanese scientists discovered that rasfonin, a compound isolated from a fungus, selectively destroys ras-dependent cells. Normal cells were not harmed. Wi...AACR awards $2.6 million in grants for metastatic colon cancer research
...Cancer." The effectiveness of combining notch and ras inhibitors such as gamma secretase inhibitors will be examined in colon cancer cells as a prerequisite to designing a Phase I clinical trial. Oliver Stoeltzing, M.D., Universitaet Regensburg, "The Role of Hsp 90 in Hepatic Growth of Colorectal C...A cancer promoting protein shows up in an unexpected place in the cell
...l feeling was that we had learned everything about ras that there is to know," says Mark Philips, M.D., P... One of those oncogenes was ras. There are three ras genes, and K-Ras is the most important in terms of its impact on human cancer. K-Ras acts lik...