Tag: "rats" at biology news
Jefferson scientists use gene therapy to reverse heart failure in animals
...ene for a protein, S100A1, into the heart cells of rats
with heart failure. The virus expressed the S100A1... the gene to be present only in heart cells. The rats
with heart failure were then followed for another two months, when their heart pumping function was ...
News tips from the Journal of Neuroscience
...he mesolimbic dopamine system. The authors trained rats
to discriminate between vehicle and delta-9-tetrah...yllycaconitine (MLA) diminished the ability of the rats
to make this discrimination, whereas the non-α 7 receptor antagonist dihydrobetaerythroidine (...
Soy estrogens and breast cancer: Researcher offers overview
...dings. Some found that feeding genistein to female rats
prior to puberty reduced the number of chemically induced mammary tumors. Other studies showed that estradiol, a primary human estrogen, spurs the growth of existing estrogen-dependent breast tumors. Helferich and colleagues demonstrated that like...
Fatty acid catabolism higher due to polyphenol intake
...t polyphenols increase the fatty acid breakdown in rats
and influence the glucose use in fat cells. De ...ol metabolites. This research was carried out with rats
to study the mechanisms and effects of a polyphenol-rich diet. Relevant polyphenol metabolites that ...
DNA-damage test could aid drug development
...by industry partners, will be to test the assay in rats
and other organisms, and with a wide variety of other toxic chemicals. "This research is the first stage in a new type of clinical drug toxicity test," says Lodish. "And although we haven't done it, you may be able to extend the technique to humans...
Insulin therapy shown to treat early experimental diabetic retinopathy
...itro and in vivo using R28 cells in culture and SD rats
respectively. Lead researcher Ravi S.J. Singh, ...ular delivery of insulin to the retina of diabetic rats
does not alter blood glucose levels and may treat early diabetic retinopathy....
Molecule that destroys bone also protects it, new research shows
...-17. Other researchers had shown previously, using rats
and mice as animal models, that blocking the receptor for IL-17 could be an effective therapy for RA and possibly for other autoimmune diseases such as multiple sclerosis, colitis, psoriasis and lupus. The effects of an IL-17 deficiency in periodon...
The stem cells that weren't there
...ong periods of time," said Kushner. By providing rats
with a timed sequence of colored dyes in their drinking water, the researchers were able to see discrete beta cells in the rat pancreas, shining in single colors that indicated a sequence of cell divisions. In contrast, the rapidly dividing cells in ...
How does soy promote weight loss? University of Illinois scientist finds another clue
..., 6, 12, 24, and 48 hours after injection, and the rats
were weighed 24 and 48 hours after injection. All rats
received the same amount of exercise, and all rats
lost weight. But, after the third injection, de...
A cherry on top: Tart cherries may alter heart/diabetes factors
...helps the body handle fat and sugar, compared with rats
that didn't receive cherries as part of an otherwise similar diet. All of the rats
had a predisposition toward high cholesterol and pre-diabetes, but not obesity. All the measures ...
Cherries may help reduce metabolic syndrome and heart disease risk factors
... whole tart cherry powder was fed to two groups of rats
as either 1 percent or 10 percent of their diet for 90 days. Other rats
received diets with no cherry powder, but with an equal amount of carbohydrates and calories to thos...
The brain is more adept at using the nose than previously realized
...earchers attached electrodes to the brains of four rats
and trained them to distinguish different odors. ...Beshel explained. Their research showed that the rats
used the oscillations selectively. When smells were quite distinct, they used more irregular activi...
Food cue-related brain activity linked to obesity?
A unique pattern of gene expression observed in rats
may be linked to a conditioned desire for food and...ene expression linked to this motivational state - rats
conditioned to expect a chocolate-flavoured treat in a particular environment, were subsequently den...
News tips from the Journal of Neuroscience
...endings in the brainstem. The authors fed pregnant rats
a reduced-sodium diet between embryonic day 3 (E3)... period preceding tongue formation. Other pregnant rats
received the custom diet from E3 to postnatal day 28 (P28). The authors labeled three gustatory nerv...
Class of PCB's causes developmental abnormalities in rat pups
...ous. In the primary experiment, one set of adult rats
was exposed to the toxicant in their food during pregnancy and during the first three weeks after giving birth, when they nursed their pups. Another group was fed normally. After both sets of pups had been weaned, the researchers recorded the electri...
Lean for life
...ined before birth. Feeding the hormone to pregnant rats
has been found to have a lifelong impact on their offspring's predisposition to obesity. Animals born of leptin-treated mothers remain lean even when fed a fat-laden diet, while those from untreated dams gained weight and developed diabetes. The di...
New findings in smell and taste
...ower in the rat olfactory bulb is modulated by the rats
online according to task demands. This enhancement...for less than two weeks changes the brain and make rats
better smellers. The improvement comes from increasing the number of responsive small inhibitory int...
ACS News Service Weekly PressPac -- April 11, 2007
...nt study outcomes, including the use of strains of rats
that are insensitive to estrogen and choosing batches of animal feed that vary widely in their estrogenic activities. Bias is even evident in the National Toxicology Programs assessment of BPA, the writer notes. A panel chosen to review the data w...
Information processing in the central nervous system: the signalling system controlling movement
... Theiss et al. on slices of spinal cord taken from rats
indicates that reducing persistent sodium current in ventral interneurones converted both steady firing and bursting patterns into a single spike pattern, and thus its modulation may provide the CNS with the capacity to mediate dramatic changes in ne...
3 proteins may play important role in nerve-cell repair
...used nerve cells obtained from the brain tissue of rats
and mouse neuroblastoma cells growing in culture to learn more about the three proteins and their involvement in cAMP regulation. The researchers added additional copies of the three genes to the cells to increase the levels of the proteins, and t...
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