Low dose radiation evades cancer cells' protective 'radar'
...w-dose irradiated cells fared better after ATM was reactivated with chloroqine, best known as a treatment for malaria. "Tricking cancer cells into ignoring the damage signals that appear on its radar could succeed in making radiation more effective in wiping out the disease," says DeWeese. This research was fund...Licorice licks herpes virus infection
... cells for long periods of time, but when they are reactivated can cause painful symptoms and distress. While treatment for active infections is progressing nicely, it remains very challenging to treat latent infections. In particular, progress in treating herpesvirus latency has lagged behind. Appearing in t...JCI table of contents March 1, 2005
... cells for long periods of time, but when they are reactivated can cause painful symptoms and distress. While treatment for active infections is progressing nicely, it remains very challenging to treat latent infections. In particular, progress in treating herpesvirus latency has lagged behind. Appearing in t...Elizabeth Blackburn and Janet Rowley awarded
...s also are exploring whether it could be carefully reactivated to prolong cell life, in order to treat age-related and neurodegenerative disorders, ranging from skin wrinkles to blindness to cardiovascular disease. "I am deeply honored to be receiving this award," said Blackburn. "The study of telomeres and the ...Researchers discover mechanism for multiplying adult stem cells
...e what happens in laboratory mice when the gene is reactivated in adult tissue where it has long been dormant. Hochedlinger found that when he switched the gene on, the mice immediately formed tumors in the gut and in the skin where the gene was active. When he switched the gene off, the tumors subsided, demonst...Live vaccines more effective against horse herpes virus
...he same symptoms from the initial infection can be reactivated by stress later in life. Osterrieder will present his new findings on vaccine effectiveness, involving a limited study of 15 horses, at a luncheon meeting with other veterinarians and specialists at the annual American College of Veterinary Interna...Women, space travel and infection: Bed-rest study investigates female immune response
...ll study the frequency by which latent viruses are reactivated and whether participants mount an immune response to a harmless vaccine, phiX174, that is introduced during the study. "In the past, most bed-rest studies for immunity have been carried out on men. It is significant to be part of the international...Silenced gene suggests greater risk, possible marker for African-Americans with prostate cancer
...A sequencing. In other studies, Dahiya has in fact reactivated GSTP1 by reversing hypermethylation. However, the compound that does this is highly toxic, and researchers are exploring other avenues to accomplish the same result. Soybean products and other foods containing plant estrogens seem particularly promis...Sleeping beauty plays a significant role in identifying cancer genes
...h and made the genes jump again. This research had reactivated the jumping genes from millions of years of evolutionary sleep; hence the name Sleeping Beauty. In the two current research studies, specially designed Sleeping Beauty transposons were introduced into mouse DNA and made to jump around in the nucleus ...NYU biologists map out early stages of embryo formation
...cting in early embryogenesis are often erroneously reactivated in cancer cells. The research is the latest in a series of studies conducted at NYU's Center for Comparative Functional Genomics in collaboration with researchers at Harvard and Yale Universities, which set the stage for these most recent findings. A...News tips from the Journal of Neuroscience
...emise.For example, the Cdk1cyclin B1 complexcan be reactivated in Alzheimer's disease.The E3-ubiquitin ligase anaphase-promotingcomplex (APC) marks mitoticcyclins such as B1 for degradation, andAPC is activated by Cdh1 at the end ofmitosis. Because Cdh1APC remains activein postmitotic cells, Almeida et al.tested...Study in Royal Society journal on possiblity of human organ regeneration
...ate organs; and that this dormant potential can be reactivated provided that medical researchers can identify the appropriate agents (scaffolds, small molecules, etc.) that awaken the early foetal response to injury. The emerging field of Regenerative Medicine is based on this new treatment that leads to organ r...Study offers clues to origins of autoimmunity
... Center. "Our findings show how these cells can be reactivated and suggest lines of research that may lead to therapies for autoimmune diseases." B cells are part of the immune system. When properly stimulated, they produce antibodies, which bind to foreign molecules and neutralize them or target the cells they ...Restoring silenced suppressor gene kills lung-cancer cells
...the cells' growth. The study also showed that the reactivated gene is highly effective in stopping the growth of...ggests that if this gene could be delivered to, or reactivated in, the tumor cells of lung-cancer cases that are deficient in this gene, it should have a therapeut...Sight can recover quickly in amblyopia
...ng is merely deactivated, capable of being rapidly reactivated when vision is restored.And secondly, the researchers wrote in an article published in the October 20, 2005, issue of Neuron, their findings suggest that allowing children with amblyopia to use both eyes--rather than patching the stronger eye to enco...Study suggests way to re-energize immune response to chronic viral infection
...f PD-1 receptors, and blocking the PD-1/PD-L1 bond reactivated the cells' response to infection." Just as strikingly, researchers found that even in persistently infected mice that lacked a type of T cell known as helper CD4, preventing PD-1 from binding to PD-L1 had a beneficial effect on "helpless" CD8 T cell...Structure determined for key molecular complex involved in long-term gene storage
...trigger cancers and other disorders should they be reactivated later in life. Cancer researchers and others have been eager to learn more about the molecules that direct this all-important system for managing the genome. Now, researchers at The Wistar Institute and Fox Chase Cancer Center have successfully dete...Painkillers may threaten power of vaccines
..., the strain linked to cervical cancer. Scientists reactivated the B cells in the blood samples and watched them churn out antibodies, as expected. But when researchers treated the B cells with a cox-2 inhibiting drug, the cells significantly diminished their production of antibodies showing that cox-2 is essen...Epigenetic drugs, promising for breast cancer treatment
...genetically inactivated suppressor genes is easily reactivated by pharmacological means. In this inaugural issue ...y tumours of breast cancer patients. Among these reactivated genes are those implicated in the regulation of cell proliferation, cell differentiation, programmed......old Spring Harbor Laboratory. When the researchers reactivated p53 in the mice they found that the liver tumors c... could be used to switch on p53 activity. "When we reactivated p53 in these mice, we saw two distinct tumor phenotypes," said Jacks. "In lymphomas the responses we...