Gene therapy advance treats hemophilia in mouse models
...s for hemophilia involves intravenously delivering recombinant (genetically engineered) human factor VIII protein to prevent bleeding episodes. However, the weekly to bi-weekly preventive treatments are extremely expensive, costing up to $500,000 per year. In addition, over time some patients may develop antibod...Antibiotic resistance markers in GM plants not a risk to human health
...risk to human health because the contribution that recombinant bacteria might make--should the enormous barriers to transfer be overcome--is so small that any contribution to antibiotic resistance made by GM plants must be overwhelmed by the contribution made by antibiotic prescription in clinical practice."...Engineered molecule amplifies body's immune response
...t the development of cancer. Because of this role, recombinant interferon is often used for the treatment of cert...y performing gene transfer experiments, using both recombinant viruses and transgenic mice, to establish the benefits of hyper-responsive Stat1 in vivo for treatin...Candidate hookworm vaccine shows benefits in animal study
... Peter Hotez, showed that vaccination of dogs with recombinant Ac-APR-1, an enzyme that starts the digestion of h...e ideal hookworm vaccine would be a mixture of two recombinant proteins, targeting both the infective larva and the blood-feeding adult stage (as targeted here) of...Researchers to gain wider access to knockout mice
...l genes in the mouse." Since the early 1980s, when recombinant DNA technology was used to create the first such animals, knockout mice have proven to be one of the most powerful tools available to study the function of genes and to create mouse models of human disease. Researchers have produced knockout mice wit...Researchers offer proof-of-concept for Altered Nuclear Transfer
...ually found in bacteria, and they are a staple for recombinant DNA techniques.) The stem cells resulting from this procedure proved to be just as robust and versatile as stem cells procured in the more traditional fashion. "The success of this procedure in no way precludes the need to pursue all forms of human ...Tulane receives multi-million grant for hemorrhagic fever research
...," Garry says. "We plan to make viral proteins by recombinant techniques in large amounts, to work in assays to diagnose the hemorrhagic fevers. We will make proteins that cannot cause the disease, and we'll make them for use in a biosafety level 1 lab, so these assays will be useable in the field in Africa." W...Hepatitis C complicated by morphine withdrawal
...s well as host cells, and the only one approved in recombinant form for treating HCV infection). To further these results, his lab has used a cell model system to determine the consequences of morphine withdrawal, which is a common recurring event in opioid users. Chuan-Qing Wang and colleagues examined the e...New results show the RTS,S malaria vaccine candidate protects children for at least 18 months
...s of age. The RTS,S/AS02A vaccine candidate uses a recombinant protein that fuses a part of the Plasmodium falciparum circumsporozoite protein with the hepatitis B surface antigen and targets immune responses against the stage injected by mosquitoes. Early development of this candidate was undertaken by GSK in c...Innovative research set to push boundaries of cancer care
...r effect has not been achieved. When injected as a recombinant protein, IL-12 produced toxic side effects, and varied attempts at gene therapy have show only limited success. Now, however, researchers at the H. Lee Moffitt Cancer Center and Research Institute and the University of South Florida are almost mid-w...The unfolding of amyloid's true colors
...urified, nonaggregated M{alpha} (which they called recombinant rM{alpha}) folds into amyloids remarkably quickly. In fact, rM{alpha} formed amyloids at a rate four orders of magnitude faster than the rate of formation for other well-known amyloids--A{beta} and {alpha}-synuclein, which are implicated in Alzheime...New Phase 3 data show potential benefits of Aranesp dosed every three weeks for CIA
.... About Aranesp (darbepoetin alfa) Aranesp is a recombinant erythropoietic protein (a protein that stimulates ...utionized anemia treatment with the development of recombinant erythropoietin, Epoetin alfa. Building on this heritage, Amgen developed Aranesp, a unique erythrop...Interim Aranesp data suggest major response in anemic patients with MDS
...udy's lead investigator. "Currently, there are no recombinant erythropoietic products approved for the treatment... About Aranesp (darbepoetin alfa) Aranesp is a recombinant erythropoietic protein (a protein that stimulates production of red blood cells, which carry oxygen)...Plant-derived vaccines safeguard against deadly plague
...gen during the same challenge. "The idea with any recombinant subunit vaccine is that you can pick and choose selective antigens that can confer protection and limit the potential for adverse reaction," said Mason. More than half the vaccinated animals survived the challenge with all forms of the antigen, and g...Glycoprotein hormone receptors
... oligomerization process. We first demonstrated in recombinant living cells, with a combination of biophysical methodologies (BRET and HTRF/FRET), that the TSH and lutropin (LH/CG) receptors form homo- and heterodimers, via interactions involving, primarily, their heptahelical domains. The large hormone-binding ...GlycoFi announces the first production of antibodies with human glycosylation in yeast
...ale. The company believes that as the scale-up and recombinant production of proteins in yeast is a well established technology, more easily achieved than mammalian cell culture, it should be possible to produce specific designer glycoproteins at large scale using the company's engineered yeasts. GlycoFi has alr...Vaccine provides 100 percent protection against avian flu virus in animal study
...thors of the study, the ability of this particular recombinant vaccine--a vaccine carrying only the important imm...ty is extremely encouraging. "This means that this recombinant vaccine can stimulate several lines of defense against the H5N1 virus, giving it greater therapeutic...Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
...have completed the first human clinical trial of a recombinant vaccine for the deadly toxin ricin a potential bi...vaccine, called RiVax, over the study period. As a recombinant vaccine, RiVax is a form of ricin that consists of a genetically modified subunit of the toxin, rath...New influenza vaccine takes weeks to mass produce
...are then infected with the baculovirus and produce recombinant hemagglutinin (rHA). Phase II clinical trials sho...9 or H2 influenza viruses. The preparation of the recombinant baculoviruses for the production of these antigens and the successful purifications gives us a great...New study shows antibody-interleukin complexes stimulate immune responses
... formation of immune complexes. When combined with recombinant IL-2, some IL-2/IL-2 mAb complexes cause more than...ytokine immune complexes in vivo. We next combined recombinant IL-2 with IL-2 mAb, which led to an even more dramatic expansion. This expansion effect also extende...