Do plants have the potential to vaccinate against HIV?
...t a generic strategy to increase the expression of recombinant proteins in plants. It could open the door to cheaper biopharmaceuticals. Plant-derived pharmaceuticals are of great interest because of their enormous potential for economy and scale of production. This technology could lead to production of modern ...Minor mutations in avian flu virus increase chances of human infection
...an optimize its specificity to the new host." "Our recombinant approach to the structural analysis of the Viet04 virus showed that when we inserted HA mutations that had already been shown to shift receptor preference in H3 HAs to the human respiratory tract, the mutations increased receptor preference of the Vi...International award honors discoveries in cellular and molecular immunology
...ate interferons and IL-2 in the laboratory, making recombinant cytokines available for use in clinical applications involving cancer, hepatitis and multiple sclerosis, as well as for studies of the mechanisms of molecular signaling. Taniguchi then discovered a novel family of transcription factors, the IRF famil...Human albumin from tobacco plants
...astidial transformation, in order to produce, in a recombinant form, human albumin from tobacco plants. According to her PhD thesis, plastidial transformation is an economically viable alternative, as it enables increasing the levels of HSA by between 10 and a 100 times, compared to levels obtained by nuclear tr......f WRN. The researchers began by constructing, from recombinant DNA, the portion of the protein known to have exonuclease activity. "First we had to find out where the exonuclease region was within the protein sequence," Perry says. The next step was to grow crystals of this exonuclease domain. "Only the last of...Experimental vaccine protects nonhuman primates when given after exposure to Marburg virus
... and then injected them with the vaccine (known as recombinant VSV, or rVSV) 20 to 30 minutes later. Another three monkeys infected with Marburg virus acted as controls and received a vaccine without the Marburg protein. All of the monkeys treated with rVSV following exposure to the Marburg virus survived for......ls. However, because HOXB4 protein is available in recombinant form (i.e. produced in cell culture, much like human insulin), it should be possible to treat HSCs directly with the protein, avoiding the potential problems associated with genetic manipulation of the cells. As the reviewers of the article commented......rivalent human papillomavirus types 6, 11, 16, 18, recombinant vaccine), a vaccine developed by Merck and tested by UAB investigators, is designed to protect against human papillomavirus (HPV), the sexually transmitted virus thought to be responsible for most cervical cancers. It is being hailed as the biggest b...Gene therapy completely suppresses ovarian cancer growth in animal model
...cer killing potential, vaccinia vectors expressing recombinant gene products represents a potent, non-toxic alternative for treating this deadly disease," he said....Bacteria have their own immune system protecting against outside DNA
...otech industry, where bacteria are used to produce recombinant human proteins for medical treatments and research...ndustry, which uses bacteria for the production of recombinant proteins for medicine and research. These proteins, such as insulin or human growth hormone, are cre...NIH launches effort to place more knockout mice in public repositories
...cessible to researchers. In the two decades since recombinant DNA technology was first used to produce lines of mice in which specific genes have been disrupted, or "knocked out," such mice have proven to be one of the most powerful tools available to study the function of genes and to create animal models of h...Mount Sinai School of Medicine licenses avian flu vaccine to Avimex
...accine market will use Mount Sinai's patented live recombinant Newcastle disease technology that contains an inse...and the Newcastle virus, birds vaccinated with the recombinant vaccine produced protection for both viruses. "This effective combination vaccine protects again...New therapy may mean less dietary restrictions for celiac sufferers
...acid residues in gluten." Dr. Khosla's group used recombinant bacteria to produce a form of EP-B2 that only acti...der duodenal conditions. "Our results suggest that recombinant EP-B2 should be effective as supportive therapy to help celiacs cope with the 'hidden' gluten in eve...Heat halts pain inside the body
...rnal pain." Scientists made this discovery using recombinant DNA technology to make both heat and pain receptor proteins in the same host cell and watching the molecular interactions between the TRPV1 protein and the P2X3 protein, switched on by capsaicin, the active ingredient in chilli, and ATP, respectively...Science and security in the 21st century
...igates the effect of such codes for research using recombinant DNA and comes to the conclusion that codes of conduct or non-binding reviews may not be sufficient to prevent abuse. Early this year, advocates of civil liberties in the US were up in arms after it came to light that the US National Security Agency...Einstein researchers find 'key' to unlocking world's deadliest malaria parasite
...nths whether we had successfully achieved a stable recombinant organism--and many experiments failed," says Dr. Fidock. "But with this technique, recombinant parasites are typically produced within two to four weeks, and their identification and characteriza...Innovative method for creating a human cytomegalovirus vaccine outlined
...y harmless to them. They then asked whether, using recombinant technologies, there might not be a way to shift th...trategy for developing a CMV vaccine, although the recombinant technologies available today should help to streamline the task. CMV infection is widespread in th...A single sugar found responsible for an antibody's ability to treat inflammation
...ications, and his lab is now working to generate a recombinant form of IgG that, by virtue of a sialic acid molecule attached in the right place, will be anti-inflammatory and could act as a novel treatment for autoimmune disorders. "We have the opportunity to make a much better form of IVIG that will work 100 t...Tips from the journals of the American Society for Microbiology
...gs. "The present study indicates that the tested recombinant canarypox (ALVAC-vectored) NiV vaccine candidates have the potential to protect pigs from disease and to restrict virus replication and nasal and pharyngeal shedding, thereby strictly limiting the chance for spread of the virus to uninfected animals/......isorders, diabetes and obesity. Recent advances in recombinant DNA technologies, as well as completion of the mouse genome sequence, now make this project feasible. NIH today awarded five-year cooperative agreements totaling up to $47.2 million to two groups for the creation of the knockout mice lines. Recipie...